Previous studies on the prognostic significance of serum levels of androgens in patients with chronic heart failure （CHF） have yielded conflicting results. The aim of this study was to examine the relationship betwe...Previous studies on the prognostic significance of serum levels of androgens in patients with chronic heart failure （CHF） have yielded conflicting results. The aim of this study was to examine the relationship between serum concentration of testosterone and mortality in men with systolic CHF. A total of 175 elderly men （age ≥60 years） with CHF were recruited. Total testosterone （TI＇） and sex hormone-binding globulin （SHBG） were measured, and estimated free testosterone （eFT） was calculated. The median follow-up time was 3.46 years. Of these patients, 17 had a TT level below 8 nmol I^-1 （230 ng dI^-1）, 27 had an eFT level below 0.225 nmol I^-1 （65 pg ml^-1） and 12 had both. Using the age-specific tenth percentiles of TT and eFT in healthy men in our laboratory as cutoff points, the prevalences of TT and eFT deficiency was 21.7% （38/175） and 27.4% （48/175）, respectively. Both TT and eFT were inversely associated with left ventricular ejection fraction （LVEF） and N-terminal pro-brain natriuretic peptide （NT-pro-BNP） （all P〈0.01）. Kaplan-Meier curves for patients in low, medium and high tertiles according to TT and eFT level showed significantly different cumulative survival rate （both P〈0.01 by log-rank test）. However, after adjustment for clinical variables, there were no significant associations of either TT or eFT levels with survival time （0R=0.97, 95% CI： 0.84-1.12, P=0.28 and 0R=0.92, 95% CI： 0.82-1.06, P=0.14, respectively）. Our study showed that levels of TT and eFT are commonly decreased in elderly patients with systolic CHF and related to disease severity, but they are not independent predictors for mortality.展开更多
The 30th of January 2012 was a sad day for thousands of Chinese cardiologists and geriatricians:they lost a respected and admired colleague,an outstanding leader and innovative pioneer.Professsor Shi-Wen Wang (1933～2...The 30th of January 2012 was a sad day for thousands of Chinese cardiologists and geriatricians:they lost a respected and admired colleague,an outstanding leader and innovative pioneer.Professsor Shi-Wen Wang (1933～2012),founder and director of the Institute of Geriatric Cardiology at Chinese PLA General Hospital,Editor-in-Chie f of Journal of Geriatric Cardiology,passed away on that day. Professor Wang was born in Shandong,China on January 25,1933.Her father was a postmaster in a small county town,who had managed to provide college educations for all his 4 sons and his only daughter,an extraordinary and almost heroic achievement at that time in China.Educated in several missionary and public sehools in Nanjing,Professor Wang in 1950 entered the medical school of Nanjing University,then one of the best universities in China,and obtained her M.D.degree in 1955.展开更多
Professor Ya-Ling Han (Figure 1), a famous cardiologist in China, was born in Wuhan, Hubei province, in 1953.She graduated from Harbin Medical University in 1978.After getting her doctorate in 1994 from Shanghai Secon...Professor Ya-Ling Han (Figure 1), a famous cardiologist in China, was born in Wuhan, Hubei province, in 1953.She graduated from Harbin Medical University in 1978.After getting her doctorate in 1994 from Shanghai Second Military Medical University, professor Han worked as the director and professor of the Department of Cardiology.She then worked as the vice president at Shenyang Northern Hospital since 1997.For the past two decades, she has been persistently leading the development of percutaneous coronary intervention (PCI) technique for complex coronary lesions and high risk patients.From 1998 to 1999 she received PCI Fellow training in Singapore National Heart Center for professional enhancement.展开更多
基金This study was supported by the National Natural Science Foundation of China，Ministry of Science and Technology of China，National Department Public Benefit Research Foundation by Ministry of Health of China
文摘Previous studies on the prognostic significance of serum levels of androgens in patients with chronic heart failure （CHF） have yielded conflicting results. The aim of this study was to examine the relationship between serum concentration of testosterone and mortality in men with systolic CHF. A total of 175 elderly men （age ≥60 years） with CHF were recruited. Total testosterone （TI＇） and sex hormone-binding globulin （SHBG） were measured, and estimated free testosterone （eFT） was calculated. The median follow-up time was 3.46 years. Of these patients, 17 had a TT level below 8 nmol I^-1 （230 ng dI^-1）, 27 had an eFT level below 0.225 nmol I^-1 （65 pg ml^-1） and 12 had both. Using the age-specific tenth percentiles of TT and eFT in healthy men in our laboratory as cutoff points, the prevalences of TT and eFT deficiency was 21.7% （38/175） and 27.4% （48/175）, respectively. Both TT and eFT were inversely associated with left ventricular ejection fraction （LVEF） and N-terminal pro-brain natriuretic peptide （NT-pro-BNP） （all P〈0.01）. Kaplan-Meier curves for patients in low, medium and high tertiles according to TT and eFT level showed significantly different cumulative survival rate （both P〈0.01 by log-rank test）. However, after adjustment for clinical variables, there were no significant associations of either TT or eFT levels with survival time （0R=0.97, 95% CI： 0.84-1.12, P=0.28 and 0R=0.92, 95% CI： 0.82-1.06, P=0.14, respectively）. Our study showed that levels of TT and eFT are commonly decreased in elderly patients with systolic CHF and related to disease severity, but they are not independent predictors for mortality.
文摘The 30th of January 2012 was a sad day for thousands of Chinese cardiologists and geriatricians:they lost a respected and admired colleague,an outstanding leader and innovative pioneer.Professsor Shi-Wen Wang (1933～2012),founder and director of the Institute of Geriatric Cardiology at Chinese PLA General Hospital,Editor-in-Chie f of Journal of Geriatric Cardiology,passed away on that day. Professor Wang was born in Shandong,China on January 25,1933.Her father was a postmaster in a small county town,who had managed to provide college educations for all his 4 sons and his only daughter,an extraordinary and almost heroic achievement at that time in China.Educated in several missionary and public sehools in Nanjing,Professor Wang in 1950 entered the medical school of Nanjing University,then one of the best universities in China,and obtained her M.D.degree in 1955.
文摘Professor Ya-Ling Han (Figure 1), a famous cardiologist in China, was born in Wuhan, Hubei province, in 1953.She graduated from Harbin Medical University in 1978.After getting her doctorate in 1994 from Shanghai Second Military Medical University, professor Han worked as the director and professor of the Department of Cardiology.She then worked as the vice president at Shenyang Northern Hospital since 1997.For the past two decades, she has been persistently leading the development of percutaneous coronary intervention (PCI) technique for complex coronary lesions and high risk patients.From 1998 to 1999 she received PCI Fellow training in Singapore National Heart Center for professional enhancement.
