Transarterial chemoembolization(TACE)may ravage normal liver tissues apart from the neoplastic nodules which offset the anti-tumor effect.This study aimed to evaluate the recovery of liver reserve function(LRF)after T...Transarterial chemoembolization(TACE)may ravage normal liver tissues apart from the neoplastic nodules which offset the anti-tumor effect.This study aimed to evaluate the recovery of liver reserve function(LRF)after TACE by indocyanine green(ICG)clearance test and other routine liver function tests.Forty-six newly diagnosed HCC patients who had undergone TACE as the initial treatment from January 2011 to January 2012 were enrolled in this study.The effects of age,basic ICG clearance rate and interval time between two assessments on the recovery of LRF were analyzed.We found that ICG retention rate at the 15 minutes(ICGR15)was significantly increased after TACE(12.3±8.1%vs 16.8±12.1%,P【0.01)in all the 46 patients.In particular,the ICGR15 value was increased in older patients(age】55 years,20.3±12.5%vs 13.7±7.2%,P【0.01).The interval of ICG test also affected the ICGR15 value(≤47days,17.8±11.4%after vs 12.1±7.1%before TACE,P【0.01).Our data suggested that TACE decreased LRF,especially in older patients.ICG test was more sensitive to evaluate the recovery of LRF after TACE than the Child-Pugh grade and routine liver function tests.展开更多
Titanium alloy Ti-Al-Nb-Zr has high specific strength and becomes a promising structural material used in the deep sea.The excellent corrosion resistance of the alloy is derived from the protective passive film formed...Titanium alloy Ti-Al-Nb-Zr has high specific strength and becomes a promising structural material used in the deep sea.The excellent corrosion resistance of the alloy is derived from the protective passive film formed on its surface.By now,full agreement on interpretation of the anti-corrosion performance of the film in marine environment,especially in the deep sea,has not been reached.In this work,the electrochemical performance of two-surface-state Ti-Al-Nb-Zr alloys which are treated by mechanical polishing and anodizing pre-passivation in the simulated shallow sea,1000 m and 3000 m deep sea environments,is investigated.By interpreting the electrochemical kinetic parameters,it is found that the dominant cathodic process becomes hydrogen evolution in simulated deep sea environments,but the reduction rate is restrained by high hydrostatic pressure,which arrests the passivation of the alloy.Assisted by X-ray photoelectron spectroscopy analysis,it is found that the passive film mainly consists of titanium oxides.There are intermediate oxides with non-stoichiometric ratio involved in the film formation due to the low dissolved oxygen concentration and low temperature.The results of Mott-Schottky and electrochemical impedance show that the film has n-type semiconducting property with oxygen vacancies as the main point defects.The anti-corrosion performance in simulated deep sea environments is one order of magnitude lower than that in the simulated shallow sea environment.However,from 1000 to 3000 m,the corrosion resistance is reduced very slightly.In the inner layers of the passive film and the passive film formed in simulated deep sea environments,the proportion of lowvalence titanium oxides is relatively high.The doping of low-valence titanium(Ti(Ⅱ) or Ti(Ⅲ)) results in a porous structure and ion permeability of the passive film,as well as relatively low corro sion resistance.展开更多
Dear Editor,Iron deficiency,documented by World Health Organization(WHO),is the most common nutritional deficiency,and accounts for-50%of anemia globally.Iron-deficiency anemia is notably and frequently associated wit...Dear Editor,Iron deficiency,documented by World Health Organization(WHO),is the most common nutritional deficiency,and accounts for-50%of anemia globally.Iron-deficiency anemia is notably and frequently associated with chronic heart failure,chronic kidney disease,cancer and inflammatory bowel disease.According to WHO Global Health Estimates 2014 Summary,iron-deficiency anemia is a major and prevalent public health problem worldwide,which contributes to 0.2% mortality,especially maternal and child mortality.展开更多
文摘Transarterial chemoembolization(TACE)may ravage normal liver tissues apart from the neoplastic nodules which offset the anti-tumor effect.This study aimed to evaluate the recovery of liver reserve function(LRF)after TACE by indocyanine green(ICG)clearance test and other routine liver function tests.Forty-six newly diagnosed HCC patients who had undergone TACE as the initial treatment from January 2011 to January 2012 were enrolled in this study.The effects of age,basic ICG clearance rate and interval time between two assessments on the recovery of LRF were analyzed.We found that ICG retention rate at the 15 minutes(ICGR15)was significantly increased after TACE(12.3±8.1%vs 16.8±12.1%,P【0.01)in all the 46 patients.In particular,the ICGR15 value was increased in older patients(age】55 years,20.3±12.5%vs 13.7±7.2%,P【0.01).The interval of ICG test also affected the ICGR15 value(≤47days,17.8±11.4%after vs 12.1±7.1%before TACE,P【0.01).Our data suggested that TACE decreased LRF,especially in older patients.ICG test was more sensitive to evaluate the recovery of LRF after TACE than the Child-Pugh grade and routine liver function tests.
基金This work was financially supported by the National Key Basic Research Program of China(Grant No.2017-JCJQ-ZD-024).
文摘Titanium alloy Ti-Al-Nb-Zr has high specific strength and becomes a promising structural material used in the deep sea.The excellent corrosion resistance of the alloy is derived from the protective passive film formed on its surface.By now,full agreement on interpretation of the anti-corrosion performance of the film in marine environment,especially in the deep sea,has not been reached.In this work,the electrochemical performance of two-surface-state Ti-Al-Nb-Zr alloys which are treated by mechanical polishing and anodizing pre-passivation in the simulated shallow sea,1000 m and 3000 m deep sea environments,is investigated.By interpreting the electrochemical kinetic parameters,it is found that the dominant cathodic process becomes hydrogen evolution in simulated deep sea environments,but the reduction rate is restrained by high hydrostatic pressure,which arrests the passivation of the alloy.Assisted by X-ray photoelectron spectroscopy analysis,it is found that the passive film mainly consists of titanium oxides.There are intermediate oxides with non-stoichiometric ratio involved in the film formation due to the low dissolved oxygen concentration and low temperature.The results of Mott-Schottky and electrochemical impedance show that the film has n-type semiconducting property with oxygen vacancies as the main point defects.The anti-corrosion performance in simulated deep sea environments is one order of magnitude lower than that in the simulated shallow sea environment.However,from 1000 to 3000 m,the corrosion resistance is reduced very slightly.In the inner layers of the passive film and the passive film formed in simulated deep sea environments,the proportion of lowvalence titanium oxides is relatively high.The doping of low-valence titanium(Ti(Ⅱ) or Ti(Ⅲ)) results in a porous structure and ion permeability of the passive film,as well as relatively low corro sion resistance.
文摘Dear Editor,Iron deficiency,documented by World Health Organization(WHO),is the most common nutritional deficiency,and accounts for-50%of anemia globally.Iron-deficiency anemia is notably and frequently associated with chronic heart failure,chronic kidney disease,cancer and inflammatory bowel disease.According to WHO Global Health Estimates 2014 Summary,iron-deficiency anemia is a major and prevalent public health problem worldwide,which contributes to 0.2% mortality,especially maternal and child mortality.
