To shorten operation time and improve survival rate of rats with myocardial ischemia or myocardial infarction,we use a novel device comprised of a face mask and a head/neck retainer in this study.We report the basic d...To shorten operation time and improve survival rate of rats with myocardial ischemia or myocardial infarction,we use a novel device comprised of a face mask and a head/neck retainer in this study.We report the basic design of the novel respiratory face mask(RFM) and evaluate its performance in a rat model of myocardial ischemia.The device is cost-effective and easier to handle than other devices,such as tracheal intubation.Compared with conventional tracheal intubation,we found that RFM shortens operation time significantly while keeping blood indices normal;the mean operation time for rats in the mask group was(32±3) min,and that for the intubation group was(45±7) min(P<0.05).Moreover,the size and shape of the RFM can be changed according to the body weight of rats.In conclusion,RFM is an appropriate device for the establishment of myocardial infarction or ischemia-reperfusion in rats.展开更多
基金(No.30600580) supported by the National Natural Science Foundation of China
文摘To shorten operation time and improve survival rate of rats with myocardial ischemia or myocardial infarction,we use a novel device comprised of a face mask and a head/neck retainer in this study.We report the basic design of the novel respiratory face mask(RFM) and evaluate its performance in a rat model of myocardial ischemia.The device is cost-effective and easier to handle than other devices,such as tracheal intubation.Compared with conventional tracheal intubation,we found that RFM shortens operation time significantly while keeping blood indices normal;the mean operation time for rats in the mask group was(32±3) min,and that for the intubation group was(45±7) min(P<0.05).Moreover,the size and shape of the RFM can be changed according to the body weight of rats.In conclusion,RFM is an appropriate device for the establishment of myocardial infarction or ischemia-reperfusion in rats.
