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内镜下治疗胃食管反流病的网状Meta分析
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作者 徐琦德 崔旻 +1 位作者 王海昆 姚萍 《中国内镜杂志》 2022年第12期51-62,共12页
目的射频消融术(RF)、经口无切口胃底折叠术(TIF)和抗反流黏膜切除术(ARMS)是治疗胃食管反流病(GERD)的3种内镜下治疗方式,但目前缺少直接比较研究来证明哪种手术方式最佳,该文应用网状Meta分析方法,比较不同内镜下治疗方法的临床疗效... 目的射频消融术(RF)、经口无切口胃底折叠术(TIF)和抗反流黏膜切除术(ARMS)是治疗胃食管反流病(GERD)的3种内镜下治疗方式,但目前缺少直接比较研究来证明哪种手术方式最佳,该文应用网状Meta分析方法,比较不同内镜下治疗方法的临床疗效。方法搜索中国生物医学文献数据库(CBM)、中国知网(CNKI)、维普(VIP)、万方数据(WanFang Data)、Cochrane图书馆、PubMed、Embase和Medline,自建库至2021年12月1日公开发表的符合纳入标准的随机对照试验(RCT)类文献,并根据Cochrane 5.1手册标准评估纳入文献的质量和偏倚风险。通过RevMan 5.4软件、ADDIS 16.6软件及Stata 19.0软件进行质量评价和网络分析。结果①共纳入16项研究,总计950例患者:对照组采用质子泵抑制剂(PPI)治疗或假手术(Sham)治疗,实验组采用RF、TIF或ARMS治疗;②文献质量评价结果显示,11篇文献为高质量文献,其他5篇文献为低质量文献;③网状Meta排序结果显示:在停止服药人数方面,ARMS效果最佳,之后依次是RF和TIF;在pH<4.2的酸反流时间方面,ARMS效果最佳,之后依次是RF和TIF;在控制食管下段压力方面,ARMS效果最佳,之后依次是TIF和RF;在健康相关生活质量(HRQL)评分方面,ARMS效果最佳,之后依次是TIF和RF。结论3种内镜下治疗方法的临床试验表明,ARMS在停止服药人数、pH<4.2的酸反流时间、增加食管下段压力和改善HRQL评分方面均为最优,可作为GERD非药物治疗的首选治疗方案。 展开更多
关键词 胃食管反流病 射频消融术 经口无切口胃底折叠术 抗反流黏膜切除术 网状Meta分析
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The Use of High-Performance Fatigue Mechanics and the Extended Kalman/Particle Filters,for Diagnostics and Prognostics of Aircraft Structures 被引量:4
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作者 hai-kun wang Robert Haynes +2 位作者 Hong-Zhong Huang Leiting Dong Satya N.Atluri 《Computer Modeling in Engineering & Sciences》 SCIE EI 2015年第5期1-24,共24页
In this paper,we propose an approach for diagnostics and prognostics of damaged aircraft structures,by combing high-performance fatigue mechanics with filtering theories.Fast&accurate deterministic analyses of fat... In this paper,we propose an approach for diagnostics and prognostics of damaged aircraft structures,by combing high-performance fatigue mechanics with filtering theories.Fast&accurate deterministic analyses of fatigue crack propagations are carried out,by using the Finite Element Alternating Method(FEAM)for computing SIFs,and by using the newly developed Moving Least Squares(MLS)law for computing fatigue crack growth rates.Such algorithms for simulating fatigue crack propagations are embedded in the computer program Safe-Flaw,which is called upon as a subroutine within the probabilistic framework of filter theories.Both the extended Kalman as well as particle filters are applied in this study,to obtain the statistically optimal and semi-optimal estimates of crack lengths,from a series of noisy measurements of crack-lengths over time.For the specific problem,a simple modification to the particle filter,which can drastically reduce the computational burden,is also proposed.Based on the results of such diagnostic analyses,the prognostics of aerospace structures are thereafter achieved,to estimate the probabilistic distribution of the remaining useful life.By using a simple example of a single-crack near a fastener hole,we demonstrate the concept and effectiveness of the proposed framework.This paper thus forms the scientific foundation for the recently proposed concepts of VRAMS(Virtual Risk-Informed Agile Maneuver Sustainment)and Digital Twins of aerospace vehicles. 展开更多
关键词 DIAGNOSTICS and PROGNOSTICS FATIGUE MECHANICS EXTENDED Kalmanfilter particle filter
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Substantial increase of heat-induced labor and economic loss in China under rapid economic and environmental temperature growth
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作者 Bo-Wen CHU Jian-Feng LUO +2 位作者 Ke-Xin wang Zhen-Cheng XING hai-kun wang 《Advances in Climate Change Research》 SCIE CSCD 2024年第4期708-716,共9页
Exposure to heat stress causes diminished work performance and leads to economic loss.In the last two decades,China has experienced both rapid economic development and environmental warming;however,the spatiotemporal ... Exposure to heat stress causes diminished work performance and leads to economic loss.In the last two decades,China has experienced both rapid economic development and environmental warming;however,the spatiotemporal variations of association between environmental heat and labor loss have been rarely investigated behind this double impact.Here,we evaluated the variation in China's heat-induced labor productivity loss and related economic cost from 2001 to 2019 and investigated the effect of economic development and regional warming.We found that decline in labor productivity because of heat stress increased significantly(p<0.05 for heavy-intensity work),and the corresponding economic loss also exhibited a drastic increase by 6-to 9-fold.The relative economic loss showed a slight but nonsignificant increase with an average value of 0.54%of the annual total earnings.At the sub-regional and sectoral level,adverse effects were more prominent in the southeast region,and the secondary industry sectors,such as construction and manufacturing,contributed to larger proportions of economic losses.The transformation of industrial structure made economic sectors more vulnerable to heat exposure,and increasingly preventive effects of air-conditioning use were noted on economic damage due to heat-induced productivity decline(36.0%relative economic benefits in 2019 compared to 9.7%in 2001).Our findings could provide a deep insight into heat burden on occupational health and heat adaptation strategies regionally under climate change,especially in developing areas with higher temperature and humidity environment. 展开更多
关键词 Heat stress Labor loss Wet bulb globe temperature China Economic impact
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Investigation on strong nonlinear interactions between underwater explosion and water surface based on compressible multiphase flow with phase transition
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作者 Jun Yu hai-kun wang +1 位作者 Zhen-xin Sheng Yi Hao 《Journal of Hydrodynamics》 SCIE EI CSCD 2023年第2期351-364,共14页
The strong nonlinear interactions between underwater explosion and water surface were numerically investigated using a phase transition model based on a four-equation system,which can deal with the complex deformable ... The strong nonlinear interactions between underwater explosion and water surface were numerically investigated using a phase transition model based on a four-equation system,which can deal with the complex deformable interface among different phases,including water,air,explosion bubble,and cavitation.The numerical method is verified by comparing the numerical results with experimental results,and good agreements are found.This study considers an ideal sine wave for simulating the shape of water surface.Two examples of different detonation depths of charge are investigated.In each example,the first case is the basic simulation without surface wave,and the other three cases are the simulations with sine waves of different wavelengths.Unique characteristics of the interactions,such as shock wave propagation,explosion bubble expansion,and the generation,development,and collapse of cavitation,are observed in the numerical simulations.By capturing the detailed density and pressure contours during the interaction process,we can better understand the underlying mechanisms of the explosion bubble,cavitation,and surface waves.These numerical results demonstrate that geometric nonlinearity impacts cavitation evolution and the explosion bubble movement mechanism.Additionally,the secondary cavitation phenomenon has been found in the cases without surface wave,and its fundamental physical mechanism is presented in detail.The present results can expand the existing database of multiphase flow in the underwater explosion and provide an insight into the strong nonlinear interaction between the underwater explosion and water surface. 展开更多
关键词 Underwater explosion compressible multiphase flow phase transition model CAVITATION water surface
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