BACKGROUND Ubiquilins(UBQLNs)are important factors for cell proteostasis maintenance.UBQLNs are involved in the modulation of the cell cycle,as well as in apoptosis,membrane receptors regulation,DNA repair,epithelial-...BACKGROUND Ubiquilins(UBQLNs)are important factors for cell proteostasis maintenance.UBQLNs are involved in the modulation of the cell cycle,as well as in apoptosis,membrane receptors regulation,DNA repair,epithelial-mesenchymal transition,and mi RNA activities.They also affect the selection of double-strand break repair pathways.Abnormal UBQLNs expression can lead to many diseases,including cancer.Studies have found that the expression of Ubiquilin4(UBQLN4)is associated with the development of several tumor types.However,the association between UBQLN4 and cervical cancer has not been examined yet.AIM To investigate the expression of UBQLN4 in cervical cancer and to evaluate its correlation with disease prognosis.METHODS Immunohistochemistry was performed to examine the expression of UBQLN4 in 117 cervical cancer tissues and 32 matching pericervical tissues.Paired t-test(twotailed)was used to compare the differences between groups.We collected patients’clinical characteristics,including age,histological grade,pathologic type,lymph node metastasis,and FIGO stage(2018)and compared them by chi-square test.All patients were followed for 5.5 to 6.8 years.Kaplan-Meier method and logrank test were used to compare the differences in the overall survival(OS)and progression-free survival(PFS)among the different groups.RESULTS Overexpression of UBQLN4 was observed in 70.9%(83/117)of all cervical cancer tissues and in 15.6%(5/32)of the paired parauterine tissues.The expression of UBQLN4 was associated with lymph node metastasis,poor differentiation,and advanced stage,but the difference was not significant.Kaplan-Meier and log-rank test results suggested the high expression of UBQLN4 was associated with short OS and PFS.Regardless of UBQLN4 expression,the patient age and FIGO stage were also associated with disease prognosis.The statistically significant variables obtained from univariate the Kaplan-Meier analysis were subjected to Cox multivariate survival regression analysis,which showed that,in addition to the FIGO stage and age,UBQLN4 was also an independent prognostic marker for OS and PFS(P=0.011 and P=0.024,respectively).CONCLUSION The overexpression of UBQLN4 was associated with poor prognosis in cervical cancer.Our study proposed a novel prognostic factor and improved the existing understanding of the pathogenesis of cervical cancer.展开更多
In this study, two polymeric resins with different pore sizes were synthesized to study comparative adsorption of reactive black KNB dye. Styrene-divinylbenzene copolymer resin NG-8 has an average pore size of 3.82 nm...In this study, two polymeric resins with different pore sizes were synthesized to study comparative adsorption of reactive black KNB dye. Styrene-divinylbenzene copolymer resin NG-8 has an average pore size of 3.82 nm, about half of that of polydivinylbenzene resin NG-7 （6.90 nm）. NG-8 also has a surface acidity about 4 times that of NG-7, resulting in a much more negative surface of the former resin as compared to the latter at pH 6.05. Equilibrium adsorption of KNB was significantly influenced by the surface functionality of the resins, as evidenced by the observations that NG-8 adsorbed constantly less KNB than NG-7 and that the presence of CaCl2 enhanced the adsorption by both resins. The intra-particle diffusion appears to be the primary rate-limiting process. While the pores of both resins are accessible to KNB, the slower adsorption by NG-8 than by NG-7 suggests that the smaller pores of NG-8 further retard the intra-particle diffusion of KNB.展开更多
BACKGROUND Acute pancreatitis is an uncommon complication of gastrointestinal endoscopy,especially if the patient has none of the common risk factors associated with pancreatitis;such as alcoholism,gallstones,hypertri...BACKGROUND Acute pancreatitis is an uncommon complication of gastrointestinal endoscopy,especially if the patient has none of the common risk factors associated with pancreatitis;such as alcoholism,gallstones,hypertriglyceridemia,hypercalcemia or the use of certain drugs.CASE SUMMARY A 56-year-old female patient developed abdominal pain immediately after the completion of an upper gastrointestinal endoscopy.The pain was predominantly in the upper and middle abdomen and was persistent and severe.The patient was diagnosed with acute pancreatitis.Treatment included complete fasting,octreotide injection prepared in a prefilled syringe to inhibit pancreatic enzymes secretion,ulinastatin injection to inhibit pancreatic enzymes activity,esomeprazole for gastric acid suppression,fluid replacement and nutritional support.Over the next 3 d,the patient's symptoms improved.The patient remained hemodynamically stable throughout hospitalization and was discharged home in a clinically stable state.CONCLUSION Pancreatitis should be considered in the differential diagnosis of abdominal pain after upper and lower gastrointestinal endoscopy.展开更多
In order to make a breakthrough in Mesozoic-Paleozoic shale gas exploration in the South Yellow Sea Basin,a comparison of the preservation conditions was made within the Barnett shale gas reservoirs in the Fortworth B...In order to make a breakthrough in Mesozoic-Paleozoic shale gas exploration in the South Yellow Sea Basin,a comparison of the preservation conditions was made within the Barnett shale gas reservoirs in the Fortworth Basin,the Jiaoshiba shale gas reservoirs in Sichuan Basin and potential shale gas reservoirs in Guizhou Province.The results show that the "Sandwich"structure is of great importance for shale gas accumulation.Therein to,the "Sandwich"structure is a kind of special reservoir-cap rock assemblage which consist of limestone or dolomite on the top,mudstone or shale layer in the middle and limestone or dolomite at the bottom.In consideration of the Mesozoic-Paleozoie in the Lower Yangtze,and Laoshan Uplift with weak Paleozoic deformation and thrust fault sealing On both flanks of the Laoshan Uplift,a conclusion can be drawn that the preservation conditions of shale gas probably developed "Sandwich" structures in the Lower Cambrian and Permian,which are key layers for the breakthrough of shale gas in the South Yellow Sea.Moreover,the preferred targets for shale gas drilling probably locate at both flanks of the Laoshan Uplift.展开更多
Objective: To explore the clinical efficacy of neurogrowth factor in the treatment of gingival pain and swelling in patients with dental pulp necrosis after root canal therapy and the effect on the serum inflammatory ...Objective: To explore the clinical efficacy of neurogrowth factor in the treatment of gingival pain and swelling in patients with dental pulp necrosis after root canal therapy and the effect on the serum inflammatory cytokines. Methods: A total of 156 patients with gingival pain and swelling after root canal therapy due to dental pulp necrosis were included in the study and randomized into the control group (n=78) and teh treatment group (n=78). The patients in the control group were given metronidazole tablets. On the above basis, the patients in the treatment group were given local injection of neurogrowth factors. 10-day treatment was regarded as one course, and the patients were continuously treated for 2 courses. The improvement of clinical symptoms before and after treatment in the two groups was evaluated. Gingival sulcus index and serum inflammatory cytokines before and after treatment in the two groups were detected and compared. Results: When compared with before treatment, the periodontal soft tissue swelling, tooth mobility, and periapical pain scores after treatment in the two groups were significantly reduced, and those in the treatment group were significantly lower than those in the control group. When compared with before treatment, the gingival sulcus bleeding index 1 and 2 courses after treatment in the two groups was significantly reduced, and that 2 courses after treatment was significantly lower than that after 1 course treatment. The gingival sulcus bleeding index 1 and 2 courses after treatment in the treatment group was significantly lower than that in the control group. When compared with before treatment, the serum IL-8 and IL-6 levels after treatment in the two groups, and TNF-α level after treatment in the treatment group were significantly reduced, and the above indicators in the treatment group were significantly lower than those in the control group. Conclusions: The neurogrowth factors in the treatment of gingival pain and swelling in patients with dental pulp necrosis after root canal therapy can effectively improve the clinical symptoms, and inhibit the inflammatory reaction, with a significant efficacy.展开更多
文摘BACKGROUND Ubiquilins(UBQLNs)are important factors for cell proteostasis maintenance.UBQLNs are involved in the modulation of the cell cycle,as well as in apoptosis,membrane receptors regulation,DNA repair,epithelial-mesenchymal transition,and mi RNA activities.They also affect the selection of double-strand break repair pathways.Abnormal UBQLNs expression can lead to many diseases,including cancer.Studies have found that the expression of Ubiquilin4(UBQLN4)is associated with the development of several tumor types.However,the association between UBQLN4 and cervical cancer has not been examined yet.AIM To investigate the expression of UBQLN4 in cervical cancer and to evaluate its correlation with disease prognosis.METHODS Immunohistochemistry was performed to examine the expression of UBQLN4 in 117 cervical cancer tissues and 32 matching pericervical tissues.Paired t-test(twotailed)was used to compare the differences between groups.We collected patients’clinical characteristics,including age,histological grade,pathologic type,lymph node metastasis,and FIGO stage(2018)and compared them by chi-square test.All patients were followed for 5.5 to 6.8 years.Kaplan-Meier method and logrank test were used to compare the differences in the overall survival(OS)and progression-free survival(PFS)among the different groups.RESULTS Overexpression of UBQLN4 was observed in 70.9%(83/117)of all cervical cancer tissues and in 15.6%(5/32)of the paired parauterine tissues.The expression of UBQLN4 was associated with lymph node metastasis,poor differentiation,and advanced stage,but the difference was not significant.Kaplan-Meier and log-rank test results suggested the high expression of UBQLN4 was associated with short OS and PFS.Regardless of UBQLN4 expression,the patient age and FIGO stage were also associated with disease prognosis.The statistically significant variables obtained from univariate the Kaplan-Meier analysis were subjected to Cox multivariate survival regression analysis,which showed that,in addition to the FIGO stage and age,UBQLN4 was also an independent prognostic marker for OS and PFS(P=0.011 and P=0.024,respectively).CONCLUSION The overexpression of UBQLN4 was associated with poor prognosis in cervical cancer.Our study proposed a novel prognostic factor and improved the existing understanding of the pathogenesis of cervical cancer.
基金This work was financially support by the State Key Laboratory of Pollution Control and Resources Reuse, China (Tongji University, Grant PCRRF 05003).
文摘In this study, two polymeric resins with different pore sizes were synthesized to study comparative adsorption of reactive black KNB dye. Styrene-divinylbenzene copolymer resin NG-8 has an average pore size of 3.82 nm, about half of that of polydivinylbenzene resin NG-7 （6.90 nm）. NG-8 also has a surface acidity about 4 times that of NG-7, resulting in a much more negative surface of the former resin as compared to the latter at pH 6.05. Equilibrium adsorption of KNB was significantly influenced by the surface functionality of the resins, as evidenced by the observations that NG-8 adsorbed constantly less KNB than NG-7 and that the presence of CaCl2 enhanced the adsorption by both resins. The intra-particle diffusion appears to be the primary rate-limiting process. While the pores of both resins are accessible to KNB, the slower adsorption by NG-8 than by NG-7 suggests that the smaller pores of NG-8 further retard the intra-particle diffusion of KNB.
基金Supported by Medical Health Science and Technology Project of Zhejiang Provincial Health Commission,No.2020ZH080the Medical and Health Care Project of Lishui,No.2021SJZC059.
文摘BACKGROUND Acute pancreatitis is an uncommon complication of gastrointestinal endoscopy,especially if the patient has none of the common risk factors associated with pancreatitis;such as alcoholism,gallstones,hypertriglyceridemia,hypercalcemia or the use of certain drugs.CASE SUMMARY A 56-year-old female patient developed abdominal pain immediately after the completion of an upper gastrointestinal endoscopy.The pain was predominantly in the upper and middle abdomen and was persistent and severe.The patient was diagnosed with acute pancreatitis.Treatment included complete fasting,octreotide injection prepared in a prefilled syringe to inhibit pancreatic enzymes secretion,ulinastatin injection to inhibit pancreatic enzymes activity,esomeprazole for gastric acid suppression,fluid replacement and nutritional support.Over the next 3 d,the patient's symptoms improved.The patient remained hemodynamically stable throughout hospitalization and was discharged home in a clinically stable state.CONCLUSION Pancreatitis should be considered in the differential diagnosis of abdominal pain after upper and lower gastrointestinal endoscopy.
基金the Project of China Geological Survey (DD20160512, DD20160346)Science and Technology Development Fund Project of Shinan District (2018-4-006-ZH)+2 种基金Key Laboratory of Marine Hydrocarbon Resources and Environmental Geology,Ministry of Land and Resources (MRE201311)National Natural Science Foundation (41776075,41702162)Natural Science Foundation of Shandong Province of China (ZR2017BD034).
文摘In order to make a breakthrough in Mesozoic-Paleozoic shale gas exploration in the South Yellow Sea Basin,a comparison of the preservation conditions was made within the Barnett shale gas reservoirs in the Fortworth Basin,the Jiaoshiba shale gas reservoirs in Sichuan Basin and potential shale gas reservoirs in Guizhou Province.The results show that the "Sandwich"structure is of great importance for shale gas accumulation.Therein to,the "Sandwich"structure is a kind of special reservoir-cap rock assemblage which consist of limestone or dolomite on the top,mudstone or shale layer in the middle and limestone or dolomite at the bottom.In consideration of the Mesozoic-Paleozoie in the Lower Yangtze,and Laoshan Uplift with weak Paleozoic deformation and thrust fault sealing On both flanks of the Laoshan Uplift,a conclusion can be drawn that the preservation conditions of shale gas probably developed "Sandwich" structures in the Lower Cambrian and Permian,which are key layers for the breakthrough of shale gas in the South Yellow Sea.Moreover,the preferred targets for shale gas drilling probably locate at both flanks of the Laoshan Uplift.
文摘Objective: To explore the clinical efficacy of neurogrowth factor in the treatment of gingival pain and swelling in patients with dental pulp necrosis after root canal therapy and the effect on the serum inflammatory cytokines. Methods: A total of 156 patients with gingival pain and swelling after root canal therapy due to dental pulp necrosis were included in the study and randomized into the control group (n=78) and teh treatment group (n=78). The patients in the control group were given metronidazole tablets. On the above basis, the patients in the treatment group were given local injection of neurogrowth factors. 10-day treatment was regarded as one course, and the patients were continuously treated for 2 courses. The improvement of clinical symptoms before and after treatment in the two groups was evaluated. Gingival sulcus index and serum inflammatory cytokines before and after treatment in the two groups were detected and compared. Results: When compared with before treatment, the periodontal soft tissue swelling, tooth mobility, and periapical pain scores after treatment in the two groups were significantly reduced, and those in the treatment group were significantly lower than those in the control group. When compared with before treatment, the gingival sulcus bleeding index 1 and 2 courses after treatment in the two groups was significantly reduced, and that 2 courses after treatment was significantly lower than that after 1 course treatment. The gingival sulcus bleeding index 1 and 2 courses after treatment in the treatment group was significantly lower than that in the control group. When compared with before treatment, the serum IL-8 and IL-6 levels after treatment in the two groups, and TNF-α level after treatment in the treatment group were significantly reduced, and the above indicators in the treatment group were significantly lower than those in the control group. Conclusions: The neurogrowth factors in the treatment of gingival pain and swelling in patients with dental pulp necrosis after root canal therapy can effectively improve the clinical symptoms, and inhibit the inflammatory reaction, with a significant efficacy.
