Inverse spin Hall effect in ITO/YIG exited by spin pumping and spin Seebeck experiments

Spin currents, which are excited in indium tin oxide(ITO)/yttrium iron garnet(YIG) by the methods of spin pumping and spin Seebeck effect, are investigated through the inverse spin Hall effect(ISHE). It is demonstrated that the ISHE voltage can be generated in ITO by spin pumping under both in-plane and out-of-plane magnetization configurations.Moreover, it is observed that the enhancement of spin Hall angle and interfacial spin mixing conductance can be achieved by an appropriate annealing process. However, the ISHE voltage is hardly seen in the presence of a longitudinal temperature gradient. The absence of the longitudinal spin Seebeck effect can be ascribed to the almost equal thermal conductivity of ITO and YIG and specific interface structure, or to the large negative temperature dependent spin mixing conductance.

Near-infrared fluorescent labeled CGRRAGGSC peptides for optical imaging of IL-11Rα in athymic mice bearing tumor xenografts

The interleukin-11(IL-11)and the IL-11 receptorα-subunit(IL-11Rα)have been demonstrated to regulate the invasion and proliferation of tumor cells.Our study intends to evaluate a noninvasive imaging of IL-11Rαexpression in breast tumors using near-infrared(NIR)fluorescent dye Cy7-labeled IL-11 mimic peptide CGRRAGGSC.This work evaluated the IL-11Rαexpression of breast tumor cells and the binding status of this peptide to IL-11Rαin vitro and in vivo by using Western blotting,immunofluorescence staining and near-infrared fluorescence imaging.Our biochemical study showed that IL-11Rαwas overexpressed in breast tumor cells(MCF-7).The cell-binding assay demonstrated specific binding of peptide CGRRAGGSC to MCF-7 cells in vitro.In vivo imaging results showed that NIR fluorescent signals of Cy7-CGRRAGGSC were selectively accumulated in tumor and metabolic organs.While in the blocking experiment,free CGRRAGGSC obviously blocked the concentration of the Cy7-CGRRAGGSC in the tumors.These results suggested that IL-11Rαmay be used as a potential target for noninvasive imaging in IL-11Rαoverexpressed tumors.Furthermore,the imaging agent of near-infrared fluorescent dye Cy7-labeled CGRRAGGSC is suitable for IL-11Rαexpression imaging study in vivo.

Spin current transmission in Co1-xTbx films

We investigate the spin to charge conversion phenomena in Y_(3)Fe_(5)O_(12)/Pt/Co_(1-x)Tb_(x)/Pt multilayers by both the spin pumping and spin Seebeck effects.We find that the spin transport efficiency is irrelevant to magnetization states of the perpendicular magnetized Co;Tb;films,which can be attributed to the symmetry requirement of the inverse transverse spin Hall effect.Furthermore,the spin transmission efficiency is significantly affected by the film concentration,revealing the dominant role of extrinsic impurity scattering caused by Tb impurity.The present results provide further guidance for enhancing the spin transport efficiency and developing spintronic devices.

Furin Enzyme-Responsive siRNA Delivery System for Efficient Anti-Hypoxia-Assisted Cancer Photodynamic Therapy

RNA interfering therapy has emerged as a promising therapeutic modality to treat cancer.The specific and efficient delivery of RNA into a tumor is crucial for achieving effective cancer gene therapy but remains a huge challenge.Herein,we report a novel furin-responsive small interfering RNA(siRNA)delivery vehicle with multiple functions for colorectal tumor treatment.A peptide-based siRNA delivery vehicle RVRR-P18-Gd,consisting of furin enzyme-specific peptide substrate Arg-Val-Arg-Arg(RVRR)with positive charge for siRNA binding,a Gd(III)chelated 1,4,7,10-tetraazacyclododecane-N,N′,N″,N‴-tetraacetic acid(DOTA)(DOTA-Gd)for magnetic resonance imaging,and purpurin 18 as photosensitizer for photodynamic therapy(PDT),was rationally designed and synthesized.Taking advantage of the cationic amphiphilic feature,RVRR-P18-Gd molecules spontaneously self-assembled with negatively charged Hif-1αsiRNA into stable nanoparticles via attractive electrostatic interaction,which effectively prevented siRNA degradation by nucleases,prolonged the circulation half-life,and enhanced tumor accumulation.Moreover,the specific release of Hif-1αsiRNA mediated by endogenous furin significantly downregulated Hif-1αexpression in colorectal cancer cells,resulting in enhanced therapeutic susceptibility,and with the PDT effect,effectively suppressed HCT116 tumor growth in living mice.This work highlights a powerful and universal approach to precisely deliver siRNA to targeted tumors for efficient synergistic therapy.

One-year status of hepatic venous pressure gradient measurement from 85 hospitals in China

Aims:Surveys and research on the applications of the hepatic venous pressure gradient(HVPG)are important for understanding the current status and future development of this technology in China.This article aimed to investigate the status of hepatic venous pressure gradient measurement in China in 2022.Methods:We investigated the overall status of HVPG technology in China-including hospital distribution,hospital level,annual number of cases,catheters used,average cost,indications,and current challenges by using online questionnaire.By counting the number and percentages of cases of these results,we hope to clarify the current status of HVPG measurements in China.Results:According to the survey,85 hospitals in China used HVPG technology in 2022 distributed across 29 provinces.A total of 4989 HVPG measurements were performed in all of the surveyed hospitals in 2022,of which 2813 cases(56.4%)were measured alone.The average cost of HVPG measurement was 5646.8±2327.9 CNY.Of the clinical teams who performed the measurements(sometimes multiple per hospital),94.3%(82/87)used the balloon method,and the majority of the teams(72.4%,63/87)used embolectomy catheters.Conclusions:This survey clarified the clinical application status of HVPG in China and confirmed that some medical institutions in China have established a foundation for this technology.It is still necessary to continue promoting and popularizing this technology in the future.

高敏肌钙蛋白T动态变化在晚时间窗内进行血管内治疗的急性缺血性脑卒中患者中的预测价值

目的探讨高敏肌钙蛋白T(high-sensitivity cardiac troponin T,hs-cTnT)动态变化与晚时间窗内接受机械取栓治疗的前循环大血管闭塞型急性缺血性脑卒中患者不良预后的相关性。方法共纳入161例患者,分别于入院时和24 h测量血清hs-cTnT。hs-cTnT升高定义为大于14 ng/L;hs-cTnT动态变化定义为两次测量值上升或下降超过20%且至少有一次大于14 ng/L。评价hs-cTnT动态变化与3个月时不良预后的相关性;比较入院时hs-cTnT升高与hs-cTnT动态变化预测3个月时不良预后的接收者操作特征(receiver-operating characteristic,ROC)曲线下面积(areas under the ROC curve,AUC)。结果67(41.6%)例患者发生hs-cTnT动态变化。多因素分析显示,hs-cTnT升高(P=0.014,P=0.038)和hs-cTnT动态变化(P<0.001,P<0.001)分别是不良预后和死亡的独立预测因素。AUC比较显示hs-cTnT动态变化对不良预后(AUC 0.765 vs 0.689,P=0.043)和死亡(AUC 0.818 vs 0.687,P=0.008)的预测价值要显著优于入院时hs-cTnT升高。结论hs-cTnT动态变化是晚时间窗进行血管内治疗的急性颅内大血管闭塞性脑卒中患者3个月时不良预后和死亡的独立预测因素。hs-cTnT动态变化对不良预后的预测价值要显著优于入院时hs-cTnT升高。

腔内修复急性Stanford B型主动脉夹层后支架远端主动脉重塑的因素分析

目的探究急性Stanford B型主动脉夹层患者行胸主动脉腔内修复术(thoracic endovascular aortic repair,TEVAR)后支架远端主动脉重塑不良的影响因素。方法回顾性收集2015年1月至2020年12月于我科接受TEVAR治疗的急性Stanford B型主动脉夹层患者的临床资料,观察支架远端多平面真假腔变化情况并分析支架远端主动脉重塑不良的影响因素。结果共82例患者入组,其中58例(70.7%)患有高血压,57例(69.5%)夹层延伸至髂动脉,随访期间15例(18.3%)患者支架远端出现假腔扩大。假腔扩大组支架主体远端与主动脉角度、腹腔干上方破口数、术后剩余破口数及末次随访时Ⅰ型内漏人数均大于假腔未扩大组,假腔扩大组假腔内血栓长度则小于假腔未扩大组,以上差异具有统计学意义(均P<0.05)。多因素分析显示支架主体远端与主动脉角度过大(OR=1.282,95%CI:1.104~1.486,P=0.001)、术后仍存在较多破口(OR=3.282,95%CI:1.035~10.401,P=0.043)是TEVAR术后主动脉重塑不良的危险因素。结论支架主体远端与主动脉角度过大、术后剩余破口较多是TEVAR术后支架远端主动脉重塑不良的危险因素。

经颈静脉肝内门体分流术治疗土三七所致肝窦阻塞综合征疗效分析

目的探讨经颈静脉肝内门体分流术(transjugular intrahepatic portosystemic shunt,TIPS)治疗土三七所致肝窦阻塞综合征(hepatic sinusoidal obstruction syndrome,HSOS)的安全性和有效性。方法回顾性分析2016年12月至2020年8月因服用土三七导致HSOS的16例患者临床资料,其中男10例,女6例。所有患者均先行抗凝、保肝等保守治疗且效果不佳,而后接受TIPS治疗。评估TIPS技术成功、临床成功及并发症情况。结果所有患者均成功行TIPS手术。门静脉压力梯度(porto systemic gradient,PSG)由术前(36.2±5.6)mmHg降至术后(21.2±5.0)mmHg(P<0.05)。13例(81.3%)患者取得临床成功,术后1、3个月患者天冬氨酸转氨酶(aspartate aminotransferse,AST)、丙氨酸转氨酶(alanine aminotransferase,ALT)、总胆红素(total bilirubin,TBIL)、终末期肝病模型(end-stage liver disease,MELD)评分均低于TIPS治疗前。严重的短期并发症包括感染性休克1例和腹膜炎1例。结论在抗凝、保肝等保守治疗无效的情况下,TIPS治疗土三七致肝窦阻塞综合征是安全、有效的。

MMP-2 and upconverted UV dual-mediated drug sequential delivery and on-site immobilization for enhanced multidrugresistant cancer therapy

Controlled drug delivery holds great potential for effective tumor treatment owing to the merits of overcoming drug resistance and improving therapeutic efficacy while minimizing systemic toxicity.However,accurate and controllable delivery of chemotherapeutics into tumor tissue with high efficiency remains a huge challenge.Taking advantage of the UV-emitting characteristics of upconversion nanoparticles(UCNPs),herein we for the first time report an MMP-2 enzyme and near infrared(NIR)dual-mediated sequential drug delivery and in-situ immobilization(ENDDI)system that is fabricated by decorating UCNPs with MMP-2 responsive and photocrosslinkable peptide bearing anticancer drug doxorubicin(DOX)for overcoming multidrug resistance.Upon cleavage with tumor-specific MMP-2,the peptide fragment containing a photolabile benzophenone(BP)and DOX could be released and in-situ immobilized within the tumor through the covalent crosslinking reaction between BP and neighboring biomolecules under the excitation of converted UVemission from UCNPs,which remarkably blocks the exocytosis of DOX leading to prolonged drug retention,achieving significant suppression of DOX-resistant breast tumors.Our current dual stimuli-mediated sequential drug delivery and in-situ immobilization represent a generalizable strategy for the effective treatment of multidrug resistant tumors.

江苏介入学科建设系列报告会总结

"什么是介入?""介入是干什么的?""介入是技术还是学科?"对于这些问题,很多医务人员一知半解,甚至医院领导也不完全清楚。为促进介入学科的建设与发展,2022年6月开始,在江苏省医学会与滕皋军院士的支持下,我作为江苏省医学会介入医学分会主任委员,带领核心专家团队历时一年,走遍江苏省13个地级市,面向所有地市级与县域医院举办介入学科建设报告会,与医院领导面对面交流,使参会领导对介入学科建设有了清晰全面的认识,大力推动了江苏省地市级与县域医院介入学科的建设与发展,取得了显著成效。

Building multipurpose nano-toolkit by rationally decorating NIR-Ⅱ fluorophore to meet the needs of tumor diagnosis and treatment

Phototheranostics have attracted tremendous attention in cancer diagnosis and treatment because of the noninvasiveness and promising effectiveness.Developing advanced phototheranostic agents with long emission wavelength,excellent biocompatibility,great tumor-targeting capability,and efficient therapeutic effect is highly desirable.However,the mutual constraint between imaging and therapeutic functions usually hinders their wide applications in biomedical field.To balance this contradiction,we herein rationally designed and synthesized three novel tumor-targeted NIR-Ⅱ probes(QR-2PEG_(321),QR-2PEG_(1000),and QR-2PEG_(5000)) by conjugating three different chain lengths of PEG onto an integrin α_(v)β_(3)-targeted NIR-Ⅱ heptamethine cyanine fluorophore,respectively.In virtue of the essential amphiphilic characteristics of PEG polymers,these probes display various degree of aggregation in aqueous buffer accompanying with differential NIR-Ⅱ imaging and photothermal(PTT) therapeutic performance.Both in vitro and in vivo results have demonstrated that probe QR-2PEG_(5000) has the best NIR-Ⅱ imaging performance with prominent renal clearance,whereas QR-2PEG_(321)possesses excellent photoacoustic signal as well as PTT effect,which undoubtedly provides a promising toolbox for tumor diagnosis and therapy.We thus envision that these synthesized probes have great potential to be explored as a toolkit for precise diagnosis and treatment of malignant tumors.