Recently,combination immunotherapy,which incorporates the activation of the immune system and inhibition of immune escape,has been proved to be a new powerful strategy for more efficient tumor suppression compared to ...Recently,combination immunotherapy,which incorporates the activation of the immune system and inhibition of immune escape,has been proved to be a new powerful strategy for more efficient tumor suppression compared to monotherapy.However,the major challenge is how to integrate multiple immune drugs together and efficiently convey these drugs to tumor sites.Although a variety of nanomaterials have been exploited as carriers for targeting tumor issues and the delivery of multiple drugs,their potential toxicity,immune rejection,and stability are still controversial for clinical application.Here,we proposed endogenic exosomes as drug carriers to deliver two antibodies acting as tumor-targeting molecules and block checkpoint inhibitors with specific response to the tumor microenvironment and costimulatory molecules for further improvement of therapeutic effect.The versatile exosomes exhibit excellent biocompatibility and provide a combination immunotherapy platform with synergistic advantages of activation of immune response and inhibition of immune escape.展开更多
Recently,combination immunotherapy,which incorporates the activation of the immune system and inhibition of immune escape,has been proved to be a new powerful strategy for more efficient tumor suppression compared to ...Recently,combination immunotherapy,which incorporates the activation of the immune system and inhibition of immune escape,has been proved to be a new powerful strategy for more efficient tumor suppression compared to monotherapy.However,the major challenge is how to integrate multiple immune drugs together and efficiently convey these drugs to tumor sites.Although a variety of nanomaterials have been exploited as carriers for targeting tumor issues and the delivery of multiple drugs,their potential toxicity,immune rejection,and stability are still controversial for clinical application.Here,we proposed endogenic exosomes as drug carriers to deliver two antibodies acting as tumor-targeting molecules and block checkpoint inhibitors with specific response to the tumor microenvironment and costimulatory molecules for further improvement of therapeutic effect.The versatile exosomes exhibit excellent biocompatibility and provide a combination immunotherapy platform with synergistic advantages of activation of immune response and inhibition of immune escape.展开更多
基金supported by the National Natural Science Foundation of China(21927811,91859111,and 21804082)the Natural Science Foundation of Shandong Province of China(ZR2019JQ06)+1 种基金the Taishan Scholars Program of Shandong Province(tsqn.201909077)the Local Science and Technology Development Fund Guided by the Central Government(YDZX20203700002568).
文摘Recently,combination immunotherapy,which incorporates the activation of the immune system and inhibition of immune escape,has been proved to be a new powerful strategy for more efficient tumor suppression compared to monotherapy.However,the major challenge is how to integrate multiple immune drugs together and efficiently convey these drugs to tumor sites.Although a variety of nanomaterials have been exploited as carriers for targeting tumor issues and the delivery of multiple drugs,their potential toxicity,immune rejection,and stability are still controversial for clinical application.Here,we proposed endogenic exosomes as drug carriers to deliver two antibodies acting as tumor-targeting molecules and block checkpoint inhibitors with specific response to the tumor microenvironment and costimulatory molecules for further improvement of therapeutic effect.The versatile exosomes exhibit excellent biocompatibility and provide a combination immunotherapy platform with synergistic advantages of activation of immune response and inhibition of immune escape.
基金supported by the National Natural Science Foundation of China(21927811,91859111,and 21804082)the Natural Science Foundation of Shandong Province of China(ZR2019JQ06)+1 种基金the Taishan Scholars Program of Shandong Province(tsqn.201909077)the Local Science and Technology Development Fund Guided by the Central Government(YDZX20203700002568).
文摘Recently,combination immunotherapy,which incorporates the activation of the immune system and inhibition of immune escape,has been proved to be a new powerful strategy for more efficient tumor suppression compared to monotherapy.However,the major challenge is how to integrate multiple immune drugs together and efficiently convey these drugs to tumor sites.Although a variety of nanomaterials have been exploited as carriers for targeting tumor issues and the delivery of multiple drugs,their potential toxicity,immune rejection,and stability are still controversial for clinical application.Here,we proposed endogenic exosomes as drug carriers to deliver two antibodies acting as tumor-targeting molecules and block checkpoint inhibitors with specific response to the tumor microenvironment and costimulatory molecules for further improvement of therapeutic effect.The versatile exosomes exhibit excellent biocompatibility and provide a combination immunotherapy platform with synergistic advantages of activation of immune response and inhibition of immune escape.
