Nitric oxide（NO） donors are versatile tools for nitric oxide biology. The biological response of NO is dependent on the transient concentration and the sustained duration. N-Nitrosated rhodamines are photo-triggered...Nitric oxide（NO） donors are versatile tools for nitric oxide biology. The biological response of NO is dependent on the transient concentration and the sustained duration. N-Nitrosated rhodamines are photo-triggered and photo-calibrated NO donors. We recently discovered that suppression of the dihedral angle between the N-nitroso fragment with the rhodamine scaffold facilitates NO release.Inspired by this discovery, we developed a fast-releasing NO donor （NOD575） suitable for biological applications, e.g., the pulmonary arterial smooth muscle cells（PASMCs）.展开更多
基金financially supported by the National Natural Science Foundation of China (No. 21572061)the Fundamental Research Funds for the Central Universities (No. WY1516017)
文摘Nitric oxide（NO） donors are versatile tools for nitric oxide biology. The biological response of NO is dependent on the transient concentration and the sustained duration. N-Nitrosated rhodamines are photo-triggered and photo-calibrated NO donors. We recently discovered that suppression of the dihedral angle between the N-nitroso fragment with the rhodamine scaffold facilitates NO release.Inspired by this discovery, we developed a fast-releasing NO donor （NOD575） suitable for biological applications, e.g., the pulmonary arterial smooth muscle cells（PASMCs）.
