Cancer cells tend to develop resistance to chemotherapy and enhance aggressive-ness.A counterintuitive approach is to tame aggressiveness by an agent that acts opposite to chemotherapeutic agents.Based on this strateg...Cancer cells tend to develop resistance to chemotherapy and enhance aggressive-ness.A counterintuitive approach is to tame aggressiveness by an agent that acts opposite to chemotherapeutic agents.Based on this strategy,induced tumor-suppressing cells(iTSCs)have been generated from tumor cells and mesenchymal stem cells.Here,we examined the possi-bility of generating iTSCs from lymphocytes by activating PKA signaling for suppressing the pro-gression of osteosarcoma(OS).While lymphocyte-derived CM did not present anti-tumor capabilities,the activation of PKA converted them into iTSCs.Inhibiting PKA conversely gener-ated tumor-promotive secretomes.In a mouse model,PKA-activated CM suppressed tumorinduced bone destruction.Proteomics analysis revealed that moesin(MSN)and calreticulin(Calr),which are highly expressed intracellular proteins in many cancers,were enriched in PKA-activated CM,and they acted as extracellular tumor suppressors through CD44,CD47,and CD91.The study presented a unique option for cancer treatment by generating iTSCs that secret tumor-suppressive proteins such as MSN and Calr.We envision that identifying these tu-mor suppressors and predicting their binding partners such as CD44,which is an FDA-approved oncogenic target to be inhibited,may contribute to developing targeted protein therapy.展开更多
Learning control has been recognized as a powerful approach in quantum information technology. In this paper, we extend the application of differential evolution （DE） to design optimal control for various quantum sy...Learning control has been recognized as a powerful approach in quantum information technology. In this paper, we extend the application of differential evolution （DE） to design optimal control for various quantum systems. Various DE methods are introduced and analyzed, and EMSDE featuring in equally mixed strategies is employed for quantum control. Two classes of quantum control problems, including control of four-level open quantum ensembles and quantum superconducting systems, are investigated to demonstrate the performance of EMSDE for learning control of quantum systems. Numerical results verify the effectiveness of the FMSDE method for various quantum systems and show the potential for complex quantum control problems.展开更多
基金supported by The Biomechanics and Bio-materials Research Center at Indiana University-Purdue University Indianapolis,USA(No.2201-01)The NIH/Eunice Kennedy Shriver NICHD,USA(No.P50HD090215)+2 种基金The NIH/NCI Cancer Center Support Grant,USA(No.P30CA082709)The Tyler Trent Cancer Research Endowment for the Riley Hospital for Children IU-Health,USAThe Indiana University Grand ChallengeePrecision Health Initiative,USA.
文摘Cancer cells tend to develop resistance to chemotherapy and enhance aggressive-ness.A counterintuitive approach is to tame aggressiveness by an agent that acts opposite to chemotherapeutic agents.Based on this strategy,induced tumor-suppressing cells(iTSCs)have been generated from tumor cells and mesenchymal stem cells.Here,we examined the possi-bility of generating iTSCs from lymphocytes by activating PKA signaling for suppressing the pro-gression of osteosarcoma(OS).While lymphocyte-derived CM did not present anti-tumor capabilities,the activation of PKA converted them into iTSCs.Inhibiting PKA conversely gener-ated tumor-promotive secretomes.In a mouse model,PKA-activated CM suppressed tumorinduced bone destruction.Proteomics analysis revealed that moesin(MSN)and calreticulin(Calr),which are highly expressed intracellular proteins in many cancers,were enriched in PKA-activated CM,and they acted as extracellular tumor suppressors through CD44,CD47,and CD91.The study presented a unique option for cancer treatment by generating iTSCs that secret tumor-suppressive proteins such as MSN and Calr.We envision that identifying these tu-mor suppressors and predicting their binding partners such as CD44,which is an FDA-approved oncogenic target to be inhibited,may contribute to developing targeted protein therapy.
基金This paper is dedicated to Professor lan R. Petersen on the occasion of his 60th birthday. This work was supported by the National Natural Science Foundation of China （Nos. 61374092, 61432008）, the National Key Research and Development Program of China （No. 2016YFD0702100） and the Australian Research Council＇s Discovery Projects funding scheme under Project DP130101658.
文摘Learning control has been recognized as a powerful approach in quantum information technology. In this paper, we extend the application of differential evolution （DE） to design optimal control for various quantum systems. Various DE methods are introduced and analyzed, and EMSDE featuring in equally mixed strategies is employed for quantum control. Two classes of quantum control problems, including control of four-level open quantum ensembles and quantum superconducting systems, are investigated to demonstrate the performance of EMSDE for learning control of quantum systems. Numerical results verify the effectiveness of the FMSDE method for various quantum systems and show the potential for complex quantum control problems.
