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Mini review: linkage between α-Synuclein protein and cognition
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作者 Huda Saleh Ayeh Saleh +3 位作者 hailan yao Jie Cui Yong Shen Rena Li 《Translational Neurodegeneration》 SCIE CAS 2015年第1期33-38,共6页
α-synuclein is a protein that plays important roles in cognitive function in the normal brain,although its exact role is not fully understood.However,current studies reveal that defects inα-synuclein function could ... α-synuclein is a protein that plays important roles in cognitive function in the normal brain,although its exact role is not fully understood.However,current studies reveal that defects inα-synuclein function could contribute to various neurodegenerative disorders,such as Parkinson’s disease(PD),a disease with symptomatic progression of deterioration in motor and cognitive function.Recent studies show that the level ofα-synuclein in cerebrospinal fluid(CSF)is highly correlated with speed of cognitive decline,suggesting a potential role ofα-synuclein in cognitive function.In this mini review,we will be focus on literatures ofα-synuclein in cognitive function in the non-diseased brain,as well as the impact that defectiveα-synuclein has on cognition in disease brain.This will be accomplished by assessing the effects of solubleα-synuclein,α-synuclein oligomers,and extracellularα-synuclein transport,on neurodegeneration. 展开更多
关键词 Α-SYNUCLEIN Parkinson’s disease COGNITION MEMORY Learning Alzheimer’s disease
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