Polygonatum sibiricum has been widely used due to its excellent biological activities.We prepared a novel polysaccharide from P.sibiricum(PSP)in this study.According a monosaccharide composition analysis,PSP was mainl...Polygonatum sibiricum has been widely used due to its excellent biological activities.We prepared a novel polysaccharide from P.sibiricum(PSP)in this study.According a monosaccharide composition analysis,PSP was mainly composed of fructose and glucose with a molar percentage of 93.81:5.12.The main linkage types were identified asα-D-Glcp-1→and→2-β-D-Fruf-1→.The molecular weight of PSP showed no significant change after simulated salivary and gastrointestinal digestion.However,PSP could be broken down by intestinal bacteria.Our findings revealed that PSP administration increased the abundance of probiotics such as Bifidobacterium.Furthermore,the results showed that gut microbes could utilize PSP to produce short-chain fatty acids including acetic acid,propionic acid,and butyric acid.Also,the PSP fermentation broth displayed an excellent scavenging effect on free radicals,including 2,2-diphenyl-1-picrylhydrazyl radical,superoxide radical,and hydroxyl radical.In summary,this study will help to promote the application of PSP as prebiotics in functional food and the medical industry.展开更多
According to the latest consensus,many traditional diseases are considered meta-bolic diseases,such as cancer,type 2 diabetes,obesity,and cardiovascular disease.Currently,metabolic diseases are increasingly prevalent ...According to the latest consensus,many traditional diseases are considered meta-bolic diseases,such as cancer,type 2 diabetes,obesity,and cardiovascular disease.Currently,metabolic diseases are increasingly prevalent because of the ever-improving living standards and have become the leading threat to human health.Multiple therapy methods have been applied to treat these diseases,which improves the quality of life of many patients,but the overall effect is still unsatisfactory.Therefore,intensive research on the metabolic process and the pathogenesis of metabolic diseases is imperative.N6-methyladenosine(m°A)is an important modification of eukaryotic RNAs.It is a critical regulator of gene expression that is involved in different cellular functions and physiological processes.Many studies have indi-cated that m6A modification regulates the development of many metabolic processes and metabolic diseases.In this review,we summarized recent studies on the role of m6A modifica-tion in different metabolic processes and metabolic diseases.Additionally,we highlighted the potential m6A-targeted therapy for metabolic diseases,expecting to facilitate m6A-targeted strategies in the treatment of metabolic diseases.展开更多
基金supported by Department of Science and Technology of Hubei Province(2021CFA014)Major Science and Technology Project in Yunnan Province(202102AE090042)+2 种基金Educational Commission of Hubei Province of China(D20212003)Knowledge Innovation Program of Wuhan-Shuguang Project(2022020801010420)Health Commission of Hubei Province of China(ZY2021Z005,ZY2019Q003).
文摘Polygonatum sibiricum has been widely used due to its excellent biological activities.We prepared a novel polysaccharide from P.sibiricum(PSP)in this study.According a monosaccharide composition analysis,PSP was mainly composed of fructose and glucose with a molar percentage of 93.81:5.12.The main linkage types were identified asα-D-Glcp-1→and→2-β-D-Fruf-1→.The molecular weight of PSP showed no significant change after simulated salivary and gastrointestinal digestion.However,PSP could be broken down by intestinal bacteria.Our findings revealed that PSP administration increased the abundance of probiotics such as Bifidobacterium.Furthermore,the results showed that gut microbes could utilize PSP to produce short-chain fatty acids including acetic acid,propionic acid,and butyric acid.Also,the PSP fermentation broth displayed an excellent scavenging effect on free radicals,including 2,2-diphenyl-1-picrylhydrazyl radical,superoxide radical,and hydroxyl radical.In summary,this study will help to promote the application of PSP as prebiotics in functional food and the medical industry.
基金supported by the National Natural Science Foundation of China(No.81874196)the Natural Science Foundation of Chongqing,China(No.cstc2021jcyjmsxmx0536)the Undergraduate Scientific Research Cultivation Program of Army Medical University,Chongqing,China(No.2021XBK22).
文摘According to the latest consensus,many traditional diseases are considered meta-bolic diseases,such as cancer,type 2 diabetes,obesity,and cardiovascular disease.Currently,metabolic diseases are increasingly prevalent because of the ever-improving living standards and have become the leading threat to human health.Multiple therapy methods have been applied to treat these diseases,which improves the quality of life of many patients,but the overall effect is still unsatisfactory.Therefore,intensive research on the metabolic process and the pathogenesis of metabolic diseases is imperative.N6-methyladenosine(m°A)is an important modification of eukaryotic RNAs.It is a critical regulator of gene expression that is involved in different cellular functions and physiological processes.Many studies have indi-cated that m6A modification regulates the development of many metabolic processes and metabolic diseases.In this review,we summarized recent studies on the role of m6A modifica-tion in different metabolic processes and metabolic diseases.Additionally,we highlighted the potential m6A-targeted therapy for metabolic diseases,expecting to facilitate m6A-targeted strategies in the treatment of metabolic diseases.
