Bilobalide inhibits the expression of aquaporin 1, 4 and glial fibrillary acidic protein in rat brain tissue after permanent focal cerebral ischemia

The present results demonstrated that in an adult rat model of permanent middle cerebral artery occlusion （pMCAO）, pretreatment with bilobalide reduced brain water content and infarct area, down-regulated aquaporin 1, 4 mRNA expression in brain edema tissue, then inhibited their synthesis in the striatum, in particular at the early stage of ischemia （at 8 hours after pMCAO）, inhibited glial fibrillary acidic protein expression, and lightened reactive gliosis. These data sug-gest that bilobalide attenuates brain edema formation due to reduced expression of aquaporins.

Elevating photoluminescence properties of Y_(3)MgAl_(3)SiO_(12):Ce^(3+)transparent ceramics for high-power white lighting

Compared with Y_(3)Al_(5)O_(12):Ce^(3+),Y3MgAl3SiO12:Ce^(3+)(YMASG:Ce^(3+))reveals great potential for highpower white lighting with red-shift spectrum.Herein,YMASG:Ce^(3+)transparent ceramics were explored to be synthesized in the air following hot isostatic pressure(HIP)treatment to obtain tunable and optimized optical properties.Then phase purity,microstructure,transmittance,and photoluminescence of YMASG:Ce^(3+)ceramics were investigated.The emission peak of YMASG:Ce^(3+)transparent ceramic can be tuned from 573 to 592 nm with the variation of Ce^(3+)doping concentration.It should be noted that this YMASG:0.2 at%Ce^(3+)transparent ceramic with emission peak at 579 nm under 450 nm excitation exhibits the highest internal/external quantum efficiency(72%/65%).The white LED device using YMASG:0.2 at%Ce^(3+)transparent ceramic with a 0.4 mm thickness demonstrates a luminous efficiency(LE)of 106 lm/W,correlated color temperature of 3158 K,and color coordinate(0.3933,0.3265).Thermal stability can be significantly imporoved by the incorporation of Lu^(3+)in YMASG transparent ceramic,and the Y3-yLuyMgAl3SiO12:0.2 at/Ce^(3+)(y=0-2.5)transparent ceramics were fabricated.The highest thermal stability(88%@150℃of the integrated emission intensity at 25℃)can be achieved wheny=2.5.The maximum LE of 154 Im/W can be obtained from Y_(0.5)Lu_(2.5)MgAl_(3)SiO_(12):0.2 at%Ce^(3+)transparent ceramic.These results indicate that YMASG:Ce^(3+)transparent ceramics with optimized properties can be regarded as an encouraging candidate for highpower white lighting.

YAGG:Ce transparent ceramics with high luminous efficiency for solid-state lighting application

A series of Y2.985Al5–xGaxO12:0.015Ce(YAGG:Ce,x=0,1,2,3,4,5)transparent ceramics were prepared via a solid-state reaction method.Two-step sintering technique was proved to be an effective approach to prepare functional ceramics with high Ga concentration,and Y3Ga5O12(YGG)transparent ceramic was successfully prepared for the first time.According to the variation of Al/Ga ratio,regulation of band structure and luminescence properties of YAGG:Ce transparent ceramics were effectively investigated.When Ga substitutes Al sites,the tetrahedral site is more favorable compared to the octahedral site for Ga to occupy according to the first-principle calculation.A continuous blue shift of the emission from 565 to 515 nm was achieved as Ga was gradually introduced into Y3Al5O12:Ce matrix.High quality green light was obtained by coupling the YAGG:Ce ceramics with commercial blue InGaN chips.Transparent luminescence ceramics accomplished in this work can be quite prospective for high power LED application.