The rapid development of fabrication and processing technologies in the past two decades has enabled researchers to introduce nanoscale features into materials which,interestingly,have been shown to greatly regulate t...The rapid development of fabrication and processing technologies in the past two decades has enabled researchers to introduce nanoscale features into materials which,interestingly,have been shown to greatly regulate the behavior and fate of biological cells.In particular,important cell responses(such as adhesion,proliferation,differentiation,migration,and filopodial growth)have all been correlated with material nanotopography.Given its great potential,intensive efforts have been made,both experimentally and theoretically,to understand why and how cells respond to nanoscale surface features,and this article reviews recent progress in this field.Specifically,a brief overview on the fabrication and modification techniques to create nanotopography on different materials is given first.After that,a summary of important experimental findings on the mediation of nanoscale surface topography on the behavior of various cells,as well as the underlying mechanism,is provided.Finally,both classical and recently developed approaches for modeling nanotopographymediated cell adhesion and filopodial growth are reviewed.展开更多
基金Jiangsu Provincial Special Program of Medical Science[BL2012004]National Basic Research Program of China[973 Program,2014CB748600]+5 种基金Jiangsu Provincial Advanced R&D Program[BY2014059-07]National Natural Science Foundation of China[51472279]Jiangsu Six Peak of Talents Program[2013-WSW-056]Chinese Ministry of Education Star-up Fund for Overseas Scholars,and National 1000 Young Talents Program of China for supporting this worksupport from the Research Grants Council[Project No.HKU-7143/12E]of the Hong Kong Special Administration Regionseed fund[Project No.201111159112]from the University of Hong Kong。
文摘The rapid development of fabrication and processing technologies in the past two decades has enabled researchers to introduce nanoscale features into materials which,interestingly,have been shown to greatly regulate the behavior and fate of biological cells.In particular,important cell responses(such as adhesion,proliferation,differentiation,migration,and filopodial growth)have all been correlated with material nanotopography.Given its great potential,intensive efforts have been made,both experimentally and theoretically,to understand why and how cells respond to nanoscale surface features,and this article reviews recent progress in this field.Specifically,a brief overview on the fabrication and modification techniques to create nanotopography on different materials is given first.After that,a summary of important experimental findings on the mediation of nanoscale surface topography on the behavior of various cells,as well as the underlying mechanism,is provided.Finally,both classical and recently developed approaches for modeling nanotopographymediated cell adhesion and filopodial growth are reviewed.
