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Characterization of integrons and novel cassette arrays in bacteria from clinical isloates in China,2000-2014 被引量:5
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作者 Wenying Xia Ting Xu +5 位作者 Tingting Qin Pengpeng Liu Yun Liu haiquan kang Bing Gu Ping Ma 《The Journal of Biomedical Research》 CAS CSCD 2016年第4期292-303,共12页
Rapid dissemination of antibiotic resistance genes among bacterial isolates is an increasing problem in China. Integron, a conserved DNA sequence, which is carried on episomal genetic structures, plays a very importan... Rapid dissemination of antibiotic resistance genes among bacterial isolates is an increasing problem in China. Integron, a conserved DNA sequence, which is carried on episomal genetic structures, plays a very important role in development of antibiotic resistance. This systematic analysis was based on MEDLINE and EMBASE databases. We summarized the distribution and proportion of different types of gene cassette arrays ofintegrons (including class 1, 2, 3 and atypical class 1 integron) from clinical bacteria isolates in China. Fifty-six literatures were included in this study. Most of the strains were Gram-negative bacteria (94.1%, 7,364/7,822) while only 5.9% strains were Gram- positive bacteria. Class 1 integrons were detected in 54.2% (3956/7295) Gram-negative strains, aadA2 was the most popular gene cassette array detected from 60 Gram-positive bacteria while dfrA 17-aadA5 were detected in 426 Gram- negative bacteria. This study identified 12 novel gene cassette arrays which have not been previously found in any species. All the novel gene cassette arrays were detected from Gram-negative bacteria. A regional characteristic of distribution of integrons was presented in this study. The results highlight a need for continuous surveillance of integrons and provide a guide for future research on integron-mediated bacteria resistance. 展开更多
关键词 INTEGRON novel cassette arrays clinical bacteria China
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