It is challenging to match the mutual interactions between implant and host because the biomaterials usually cannot actively adjust their performance to the changing microenvironment.Surface potential is one of the cr...It is challenging to match the mutual interactions between implant and host because the biomaterials usually cannot actively adjust their performance to the changing microenvironment.Surface potential is one of the critical factors affecting the bioactivity of biomaterials,but it is difficult to be directly controlled in vivo.Magnetic stimulation has attracted much attention due to its deep penetrability,good reliability,and convenient operability.Here,titanium dioxide(TiO_(2))nanotubes and Terfenol‐D/P(VDF‐TrFE)composite film are prepared by anodic oxidation and solution casting methods on opposite sides of a titanium sheet,respectively.Terfenol‐D magnetostrictive microparticles deform under a magnetic field,generating surface potential on the P(VDF‐TrFE)piezoelectric matrix through magneto‐electric coupling.Correspondingly,equal opposite charges are induced on the surface of TiO_(2) nanotubes.Stem cells cultured on TiO_(2) nanotubes show that cell adhesion,proliferation,and differentiation abilities can be regulated by magnetic strength,which correlates with the absorption of charged proteins.Therefore,a cascade coupling of magnetic,mechanical,electric,biochemical,and cellular effects is established.This work demonstrates the feasibility of regulating the bioactivity of biomaterials in vivo through a magnetic field.展开更多
基金Guangdong Basic and Applied Basic Research Foundation,Grant/Award Numbers:2021B1515120019,2019A1515011891,2015A030312004Science and Technology Projects in Guangzhou,Grant/Award Number:202102020644Opening Project of Guangdong Provincial Key Laboratory of Technique and Equipment for Macromolecular Advanced Manufacturing,Grant/Award Number:2019kfkt01。
文摘It is challenging to match the mutual interactions between implant and host because the biomaterials usually cannot actively adjust their performance to the changing microenvironment.Surface potential is one of the critical factors affecting the bioactivity of biomaterials,but it is difficult to be directly controlled in vivo.Magnetic stimulation has attracted much attention due to its deep penetrability,good reliability,and convenient operability.Here,titanium dioxide(TiO_(2))nanotubes and Terfenol‐D/P(VDF‐TrFE)composite film are prepared by anodic oxidation and solution casting methods on opposite sides of a titanium sheet,respectively.Terfenol‐D magnetostrictive microparticles deform under a magnetic field,generating surface potential on the P(VDF‐TrFE)piezoelectric matrix through magneto‐electric coupling.Correspondingly,equal opposite charges are induced on the surface of TiO_(2) nanotubes.Stem cells cultured on TiO_(2) nanotubes show that cell adhesion,proliferation,and differentiation abilities can be regulated by magnetic strength,which correlates with the absorption of charged proteins.Therefore,a cascade coupling of magnetic,mechanical,electric,biochemical,and cellular effects is established.This work demonstrates the feasibility of regulating the bioactivity of biomaterials in vivo through a magnetic field.
