To the Editor:Polycystic ovary syndrome(PCOS)is a common endocrine disorder among women of reproductive age.PCOS is characterized by infrequent or absent ovulation,high androgen levels,and hyperinsulinaemia.Androgenic...To the Editor:Polycystic ovary syndrome(PCOS)is a common endocrine disorder among women of reproductive age.PCOS is characterized by infrequent or absent ovulation,high androgen levels,and hyperinsulinaemia.Androgenic excess is the main pathophysiological mechanism of the disease.Metformin can lower insulin and androgen levels,increase estradiol levels,and induce ovulation.^([1])Pioglitazone can increase the sensitivity of peripheral tissues to insulin,improve insulin resistance,reduce androgen levels,restore the menstrual cycle,and promote ovulation.^([2])Despite extensive research,the molecular mechanisms that mediate the beneficial effects of metformin or pioglitazone in the treatment of PCOS are still unclear.There are also differences in individual patient responses to drugs.展开更多
文摘To the Editor:Polycystic ovary syndrome(PCOS)is a common endocrine disorder among women of reproductive age.PCOS is characterized by infrequent or absent ovulation,high androgen levels,and hyperinsulinaemia.Androgenic excess is the main pathophysiological mechanism of the disease.Metformin can lower insulin and androgen levels,increase estradiol levels,and induce ovulation.^([1])Pioglitazone can increase the sensitivity of peripheral tissues to insulin,improve insulin resistance,reduce androgen levels,restore the menstrual cycle,and promote ovulation.^([2])Despite extensive research,the molecular mechanisms that mediate the beneficial effects of metformin or pioglitazone in the treatment of PCOS are still unclear.There are also differences in individual patient responses to drugs.
