Breeding and Application of Guidan 903,a New High-yield and Good-quality Maize Variety

To meet the demand of maize production in Guangxi and even the southwest region of China and realize the upgrading and undating of maize varieties which will continuously improve the yield and quality of maize,a new big-ear maize variety Guidan 903 with high yield,stable yield and good quality was established by the Maize Research Institute of Guangxi Academy of Agricultural Sciences with two self-selected inbred line GRL17349 and GRL21191 as female and male parents seperately.The average yield of this variety were 7429.5 and 7000.5 kg/hm^(2)in Guangxi Maize Regional Trial and Production Test respectively,which increased by 6.3%and 5.6%than the control(Guidan162).It was approved by Guangxi Zhuang Autonomous Region Crop Variety Certification Committee in June 2020(Approval No.Gui sheng yu 2020083).Determined by the Cereal Quality Supervision and Testing Center of Ministry of Agriculture and Rural Affairs(Bejjing),the grain bulk density,ratio of crude protein,crude fat,crude starch and lysine of Guidan 903 were 782 g/L,9.41%,6.19%,71.45%,0.35%respectively.This variety has the characterisics of strong resistance to collapse and disease,good quality,high and stable yield and wide adaptability.Furthermore,its seed yield is high with easy production technology and low cost.

A homologous and molecular dual-targeted biomimetic nanocarrier for EGFR-related non-small cell lung cancer therapy

The abnormal activation of epidermal growth factor receptor(EGFR)drives the development of non-small cell lung cancer(NSCLC).The EGFR-targeting tyrosine kinase inhibitor osimertinib is frequently used to clinically treat NSCLC and exhibits marked efficacy in patients with NSCLC who have an EGFR mutation.However,free osimertinib administration exhibits an inadequate response in vivo,with only~3%patients demonstrating a complete clinical response.Consequently,we designed a biomimetic nanoparticle(CMNP^(@Osi))comprising a polymeric nanoparticle core and tumor cell-derived membrane-coated shell that combines membrane-mediated homologous and molecular targeting for targeted drug delivery,thereby supporting a dual-target strategy for enhancing osimertinib efficacy.After intravenous injection,CMNP^(@Osi)accumulates at tumor sites and displays enhanced uptake into cancer cells based on homologous targeting.Osimertinib is subsequently released into the cytoplasm,where it suppresses the phosphorylation of upstream EGFR and the downstream AKT signaling pathway and inhibits the proliferation of NSCLC cells.Thus,this dual-targeting strategy using a biomimetic nanocarrier can enhance molecular-targeted drug delivery and improve clinical efficacy.

Intervertebral disc generation tissue engineering treatment platform:gelatin-methacryloyl hydrogel composite system

To the Editor:In middle-aged and elderly individuals,intervertebral disc(IVD)degeneration(IVDD)can often cause low back pain(LBP).IVDD has a complex mechanism with many influencing factors.Biological changes in degenerative IVDs mainly include structural abnormalities of the nucleus pulposus(NP),annulus fibrosus(AF),and cartilage endplate,as well as changes in the composition and amount of extracellular matrix(ECM).IVDD disease is treated conservatively,followed by surgery,but these are symptomatic treatments.