The cochlea plays an important role in the mammalian auditory system.Sound-induced cell motion in the cochlea is transformed into electrical signals that are then sent to primary auditory neurons.The most significant ...The cochlea plays an important role in the mammalian auditory system.Sound-induced cell motion in the cochlea is transformed into electrical signals that are then sent to primary auditory neurons.The most significant feature of the cochlea is the active and nonlinear amplification of faint sounds.This active process cannot be explained via a simple hydromechanical representation of the cochlea,that is,a macromechanic explanation.Although the mechanisms of this amplification are not well understood,cochlear micromechanical behavior is thought to play a significant role.The measurement of in vivo cochlea micromechanical responses is challenging and restricted by technical limitations.Modeling the micromechanics of the cochlea,however,can facilitate the interpretation of experimental observations.In this paper,we reviewed studies in which researchers modeled the cochlear micromechanics,and we discussed various modeling hypotheses,outcomes,and expectations.展开更多
基金supported by Tianjin Key Laboratory of Brain Science and Neural Engineering,Beijing-Tianjin-Hebei Basic Research Cooperation Project of China(No.18JCZDJC45300)Tianjin Plan of Funding Outstanding Science and Technology Projects Launched by Talents Returning from Studying Overseas of China(No.2018004).
文摘The cochlea plays an important role in the mammalian auditory system.Sound-induced cell motion in the cochlea is transformed into electrical signals that are then sent to primary auditory neurons.The most significant feature of the cochlea is the active and nonlinear amplification of faint sounds.This active process cannot be explained via a simple hydromechanical representation of the cochlea,that is,a macromechanic explanation.Although the mechanisms of this amplification are not well understood,cochlear micromechanical behavior is thought to play a significant role.The measurement of in vivo cochlea micromechanical responses is challenging and restricted by technical limitations.Modeling the micromechanics of the cochlea,however,can facilitate the interpretation of experimental observations.In this paper,we reviewed studies in which researchers modeled the cochlear micromechanics,and we discussed various modeling hypotheses,outcomes,and expectations.
