1 Introduction Obstructive atherosclerosis vascular disease remains one of the greatest public health threats in the world.Sur2 gical treatment to replace diseased blood vessels is usually done using major human allog...1 Introduction Obstructive atherosclerosis vascular disease remains one of the greatest public health threats in the world.Sur2 gical treatment to replace diseased blood vessels is usually done using major human allografts(veins or arteries)or synthetic prosthesis(PTFE,Dacron).However,these substitutes have not a good patency,because of the lack of endothelial cell s(ECs)layer,which prevent s thrombus formation.The challenge of tissue engineering vessel s i s to build2up blood/substitute interface near native vessels.In order to improve ECs adhesion,it is necessary to pre2 coat the intra2luminal vessel.Recently,a new surface modification technique arose,based on the alternate ad2 sorption of oppositely charged polyelectrolytes.Our objec2 tive was to favour the endothelialization of the cryo2pre2 served allografts,treated with a thin polyelectrolyte multi2 layered film,made of PSS(poly(sodium242styrenesul2 fonate))or PAH(poly(allylamine hydrochloride)).展开更多
1 Introduction A method in vascular tissue engineering to obtain hemocompatible synthetic prosthesis consist s to cover the luminal surface by a monolayer of endothelial cell s(ECs).Nevertheless,the surface of current...1 Introduction A method in vascular tissue engineering to obtain hemocompatible synthetic prosthesis consist s to cover the luminal surface by a monolayer of endothelial cell s(ECs).Nevertheless,the surface of current prosthesi s does not favour the development of an ECs monolayer.Recently,a new versatile method of self2assembled archi2 tectures based on the alternate adsorption of polycations and polyanions has been developed to lead to the build2up of multilayered polyelectrolyte films(MPF).This new type of surface modification offers also large possibilities for varying the physico2chemical properties such as rough2 ness or surface charges,film thickness and viscoelastic properties.展开更多
文摘1 Introduction Obstructive atherosclerosis vascular disease remains one of the greatest public health threats in the world.Sur2 gical treatment to replace diseased blood vessels is usually done using major human allografts(veins or arteries)or synthetic prosthesis(PTFE,Dacron).However,these substitutes have not a good patency,because of the lack of endothelial cell s(ECs)layer,which prevent s thrombus formation.The challenge of tissue engineering vessel s i s to build2up blood/substitute interface near native vessels.In order to improve ECs adhesion,it is necessary to pre2 coat the intra2luminal vessel.Recently,a new surface modification technique arose,based on the alternate ad2 sorption of oppositely charged polyelectrolytes.Our objec2 tive was to favour the endothelialization of the cryo2pre2 served allografts,treated with a thin polyelectrolyte multi2 layered film,made of PSS(poly(sodium242styrenesul2 fonate))or PAH(poly(allylamine hydrochloride)).
文摘1 Introduction A method in vascular tissue engineering to obtain hemocompatible synthetic prosthesis consist s to cover the luminal surface by a monolayer of endothelial cell s(ECs).Nevertheless,the surface of current prosthesi s does not favour the development of an ECs monolayer.Recently,a new versatile method of self2assembled archi2 tectures based on the alternate adsorption of polycations and polyanions has been developed to lead to the build2up of multilayered polyelectrolyte films(MPF).This new type of surface modification offers also large possibilities for varying the physico2chemical properties such as rough2 ness or surface charges,film thickness and viscoelastic properties.
