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瑞巴匹特灌肠对远端活动性结肠炎与直肠炎的疗效:一项前瞻性研究报道
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作者 Makiyama K. takeshima F. +1 位作者 hamamoto t. 李宏宇 《世界核心医学期刊文摘(胃肠病学分册)》 2006年第5期12-12,共1页
Rebamipide has a broad spectrum of pharmacological actions that include suppression of neutrophil functions and stimulation of mucosal epithelial cell regeneration by increasing the expression of epithelial growth fac... Rebamipide has a broad spectrum of pharmacological actions that include suppression of neutrophil functions and stimulation of mucosal epithelial cell regeneration by increasing the expression of epithelial growth factor (EGF) and the EGF receptor. Sixteen patients with active ulcerative colitis (UC; mild in 1 patient, moderate in 11, and severe in 4) were recruited. Enemas containing 150 mg rebamipide per dosing were administered during the daytime after passage of stool, twice a day for 4 weeks. UC disease activity index (UC-DAI), endoscopic activity index (EAI), and Floren’ s grading (FG) of mucosal biopsy specimens were measured at entry and at 4 weeks. Five of 16 patients did not complete the study, and therefore, final efficacy assessment was done on 11 patients who completed the 4 weeks of treatment. Improvements were observed in UC-DAI (P = 0.0049),EAI (P = 0.0043), and FG(P = 0.0084). There was no serious rebamipide-related side effect in any of the 16 patients. In conclusion, rebamipide topical therapy appears to be effective for the treatment of mildly to moderately active distal UC. Further controlled studies are warranted for this promising drug. 展开更多
关键词 溃疡性结肠炎 瑞巴匹特 疗效评估 活动性 灌肠剂 前瞻性研究 远端 直肠炎 上皮生长因子 EGF受体表达
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