MicroRNAs(miRNAs)are small noncoding RNAs involved in the regulation of mRNA transcription and translation,and possess all desirable features of an ideal tumor marker.Of almost 31 different miRNA clusters identified i...MicroRNAs(miRNAs)are small noncoding RNAs involved in the regulation of mRNA transcription and translation,and possess all desirable features of an ideal tumor marker.Of almost 31 different miRNA clusters identified in germ cell tumors(GCTs),miR-371a-3p has shown exceptionally high sensitivity and specificity for both seminomatous and nonseminomatous GCTs.It is easily obtainable and correlates well with tumor burden.Recent multiinstitutional prospective studies have shown promising test characteristics for miR-371a-3p as a diagnostic blood-based biomarker for GCT prior to orchiectomy including 80%e100%sensitivity and 90%e100%specificity.This accuracy may address other unmet needs in the management of patients with GCT.Early studies have suggested the utility of miR-371a-3p in detecting occult nodal metastasis in high-risk clinical stage I and early stage II disease.Ongoing clinical trials including SWOG 1823 and AGCT1531 are specifically designed to confirm the utility of miR-371a-3p in clinical stage I GCT.Despite its strong association with viable GCT after treatment with chemotherapy,miR-371a-3p does not seem to accurately predict the presence of teratoma in residual lesions.Also,standardization of extraction and interpretation methods is a necessary step to assure uniform results across different institutions.展开更多
A novel ultrahigh-speed all-optical demultiplexer （DMUX） with polarization-shift-keying （PolSK） modula- tion input signals is proposed. This design is based on four-wave mixing （FWM） in a semiconductor optical a...A novel ultrahigh-speed all-optical demultiplexer （DMUX） with polarization-shift-keying （PolSK） modula- tion input signals is proposed. This design is based on four-wave mixing （FWM） in a semiconductor optical amplifier （SOA）. For analyzing each amplifier, we use finite-difference method （FDM） based on solution of the traveling wave coupled equations. Using numerical simulation, the all-optical DMUX is theoretically realized at 40 Gb/s. We also study the relation between optical confinement factor and thickness of active layer of the SOA section successfully, and investigate the increasing effect of confinement factor on the DMUX optical output power. With this work, the confinement factor is increased from 0.3 to 0.48, and as a result, the output power approximately twice of its initial value is achieved. Moreover, the effects of polarization dependence of SOA on the output performance of all-optical DMUX for PolSK signal are theoretically investigated in detail.展开更多
文摘MicroRNAs(miRNAs)are small noncoding RNAs involved in the regulation of mRNA transcription and translation,and possess all desirable features of an ideal tumor marker.Of almost 31 different miRNA clusters identified in germ cell tumors(GCTs),miR-371a-3p has shown exceptionally high sensitivity and specificity for both seminomatous and nonseminomatous GCTs.It is easily obtainable and correlates well with tumor burden.Recent multiinstitutional prospective studies have shown promising test characteristics for miR-371a-3p as a diagnostic blood-based biomarker for GCT prior to orchiectomy including 80%e100%sensitivity and 90%e100%specificity.This accuracy may address other unmet needs in the management of patients with GCT.Early studies have suggested the utility of miR-371a-3p in detecting occult nodal metastasis in high-risk clinical stage I and early stage II disease.Ongoing clinical trials including SWOG 1823 and AGCT1531 are specifically designed to confirm the utility of miR-371a-3p in clinical stage I GCT.Despite its strong association with viable GCT after treatment with chemotherapy,miR-371a-3p does not seem to accurately predict the presence of teratoma in residual lesions.Also,standardization of extraction and interpretation methods is a necessary step to assure uniform results across different institutions.
文摘A novel ultrahigh-speed all-optical demultiplexer （DMUX） with polarization-shift-keying （PolSK） modula- tion input signals is proposed. This design is based on four-wave mixing （FWM） in a semiconductor optical amplifier （SOA）. For analyzing each amplifier, we use finite-difference method （FDM） based on solution of the traveling wave coupled equations. Using numerical simulation, the all-optical DMUX is theoretically realized at 40 Gb/s. We also study the relation between optical confinement factor and thickness of active layer of the SOA section successfully, and investigate the increasing effect of confinement factor on the DMUX optical output power. With this work, the confinement factor is increased from 0.3 to 0.48, and as a result, the output power approximately twice of its initial value is achieved. Moreover, the effects of polarization dependence of SOA on the output performance of all-optical DMUX for PolSK signal are theoretically investigated in detail.
