The current study reports the outbreaks of Peste des Petits Ruminants (PPR) in the small ruminant population of Pakistan. The objectives were to understand the clinical picture of disease under field conditions, estim...The current study reports the outbreaks of Peste des Petits Ruminants (PPR) in the small ruminant population of Pakistan. The objectives were to understand the clinical picture of disease under field conditions, estimate the basic epidemiological parameters for the local population of small ruminants and to determine the spatial and temporal distribution of PPR during 2005 to 2007 in Pakistan. A total of 62 outbreaks were investigated among sheep and goat flocks in the five provinces of Pakistan and Azad Jammu & Kashmir (AJK). The PPR virus activity in these outbreaks was demonstrated by clinical picture and presence of PPR virus specific antibodies by employing cELISA. The combined estimates of mean cumulative morbidity and mortality for sheep and goats were estimated 65.37% and 26.51% respectively with a case fatality of 40.40%. The species specific mean cumulative morbidity, mortality and case fatality for goats were 68.80%, 29.45% and 42.75% respectively, while these estimates for sheep were 48.77%, 14.98% and of 26.16% respectively. These estimates for goats were significantly higher (P < 0.001 to P = 0.001) than those for sheep. It was concluded that PPR is wide spread throughout the country and epidemiological picture suggest that disease has established as an endemic infection in the country.展开更多
The present study reports the duration of immunity and protective efficacy of Peste des Petits Ruminants (PPR) vaccine (Nigerian strain 75/1) in sheep and goats. A total of 105 sheep and goats were divided into three ...The present study reports the duration of immunity and protective efficacy of Peste des Petits Ruminants (PPR) vaccine (Nigerian strain 75/1) in sheep and goats. A total of 105 sheep and goats were divided into three groups A, B and C. Group A received normal recommended dose (1.0 ml) of PPR vaccine, group B received half dose (0.5 ml) of PPR vaccine and group C was kept as unvaccinated control group in contact with vaccinated animals. The post vaccination dynamics of antibodies against PPR virus was studied. It was found that significant antibody titres persisted for 3 years post vaccination in sheep and goats vaccinated with either full dose or half dose of PPR vaccine. The challenge protection studies were carried out in experimental animals at 24 and 36 month post vaccination. The vaccinates withstood challenge and were found completely resistant clinically and virologically to virulent PPR virus for 24 and 36 months post vaccination. The unvaccinated control animals developed typical clinical signs of PPR and the challenged virus was detected in ocular, nasal and oral secretions of these animals. This study demonstrated that a single immunization with PPR vaccine conferred solid protection in sheep and goats for 3 years.展开更多
文摘The current study reports the outbreaks of Peste des Petits Ruminants (PPR) in the small ruminant population of Pakistan. The objectives were to understand the clinical picture of disease under field conditions, estimate the basic epidemiological parameters for the local population of small ruminants and to determine the spatial and temporal distribution of PPR during 2005 to 2007 in Pakistan. A total of 62 outbreaks were investigated among sheep and goat flocks in the five provinces of Pakistan and Azad Jammu & Kashmir (AJK). The PPR virus activity in these outbreaks was demonstrated by clinical picture and presence of PPR virus specific antibodies by employing cELISA. The combined estimates of mean cumulative morbidity and mortality for sheep and goats were estimated 65.37% and 26.51% respectively with a case fatality of 40.40%. The species specific mean cumulative morbidity, mortality and case fatality for goats were 68.80%, 29.45% and 42.75% respectively, while these estimates for sheep were 48.77%, 14.98% and of 26.16% respectively. These estimates for goats were significantly higher (P < 0.001 to P = 0.001) than those for sheep. It was concluded that PPR is wide spread throughout the country and epidemiological picture suggest that disease has established as an endemic infection in the country.
文摘The present study reports the duration of immunity and protective efficacy of Peste des Petits Ruminants (PPR) vaccine (Nigerian strain 75/1) in sheep and goats. A total of 105 sheep and goats were divided into three groups A, B and C. Group A received normal recommended dose (1.0 ml) of PPR vaccine, group B received half dose (0.5 ml) of PPR vaccine and group C was kept as unvaccinated control group in contact with vaccinated animals. The post vaccination dynamics of antibodies against PPR virus was studied. It was found that significant antibody titres persisted for 3 years post vaccination in sheep and goats vaccinated with either full dose or half dose of PPR vaccine. The challenge protection studies were carried out in experimental animals at 24 and 36 month post vaccination. The vaccinates withstood challenge and were found completely resistant clinically and virologically to virulent PPR virus for 24 and 36 months post vaccination. The unvaccinated control animals developed typical clinical signs of PPR and the challenged virus was detected in ocular, nasal and oral secretions of these animals. This study demonstrated that a single immunization with PPR vaccine conferred solid protection in sheep and goats for 3 years.
