Pentoxifylline in hepatopulmonary syndrome

AIM:To determine the effects of pentoxifylline(PTX) on clinical manifestations and evaluate arterial blood gas data in hepatopulmonary syndrome(HPS) in children.METHODS:In a pilot study of 10 children with chronic liver disease,who had HPS,20 mg/kg/d PTX was administered for 3 mo.Clinical data and arterial blood gas parameters were evaluated at baseline,the end of the treatment period,and 3 mo after drug discontinuation.RESULTS:Six patients could tolerate PTX,while four patients experienced complications.Among patients who could tolerate PTX,there was a significant increase in arterial oxygen pressure(PaO 2)(P = 0.02) and oxygen saturation(SaO 2)(P = 0.04) and alveolar-arterial oxygen gradient(P = 0.02) after 3 mo of treatment.Significant decreases in PaO 2(P = 0.02) and alveolararterial oxygen gradient(P = 0.02) were also seen after drug discontinuation.CONCLUSION:PTX may improve PaO 2,SaO 2 and alveolar-arterial oxygen gradient in the early stage of HPS.

Effect of oral garlic on arterial oxygen pressure in children with hepatopulmonary syndrome

瞄准：与肝肺症候群在孩子在动脉的氧压力上学习口头的大蒜的效果。方法：在一种囊形式的大蒜粉末与肝肺症候群被给 15 个孩子(由对比回响心动描记法证实了) 在 1 g/1.73 m (2 ) 的剂量每天。病人们每四个星期临床上并且由动脉的血气体被评估。结果：大蒜囊与肝肺症候群予 15 个病人被以。与 9.4+/-3.9 年的吝啬的年龄有 10 个男孩和 5 个女孩。内在的问题是胆道闭锁(4 个病人) ，自体免疫的肝炎(4 个病人) ，起因不明的肝硬化(4 个病人) 和 presinusoidal 门静脉高血压(3 个病人) 。八个病人(53.3%) 在他们的吝啬的动脉的氧压力显示出 10 毫米汞柱的增加。基线 PaO (2 ) 在非应答者组是在应答者组和 47.1+/-11.2 毫米汞柱的 65.6+/-12.1 毫米汞柱。在治疗的目的，在应答者和非应答者的吝啬的 PaO (2 ) 是 92.2+/-7.75 毫米汞柱和 47.5+/-11.87 毫米汞柱，分别地(P【0.01 ) 。结论：大蒜可以增加氧化并且与肝肺症候群在孩子改进呼吸困难。