目的利用指南研究与评价工具Ⅱ(AGREEⅡ)系统评价国内外最新版本的慢性乙型肝炎(CHB)管理指南,以促进高质量的指南应用于临床,并推动低质量指南的不断改进。方法检索中国知网(CNKI)、万方数据库、维普、SinoMed、PubMed、Embase、Cocran...目的利用指南研究与评价工具Ⅱ(AGREEⅡ)系统评价国内外最新版本的慢性乙型肝炎(CHB)管理指南,以促进高质量的指南应用于临床,并推动低质量指南的不断改进。方法检索中国知网(CNKI)、万方数据库、维普、SinoMed、PubMed、Embase、CocraneLibrary、Web of Science等数据库,以及中国临床指南文库(China Guideline Clearinghouse,CGC)、医脉通临床指南网、美国国家临床指南数据库(National Guideline Clearinghouse,NGC)、国际指南协作网(Guidelines International Network,GIN)、英国国家临床优化研究所(National Institute for Clinical Excellence,NICE)、苏格兰学院间指南网络(Scottish Inter-Academic Guide Network,SIGN)、澳大利亚临床实践指南(Australian Clinical Practice Guidelines,ACPG)等官方网站,补充检索谷歌学术、百度学术,搜集近10年CHB管理的相关指南,检索时限为2011年1月1日至2020年12月31日。利用AGREEⅡ评价指南的方法学质量,并比较纳入的指南在CHB抗病毒适应证的不同。结果共纳入指南19部。6个评价领域中,“范围与目的”“参与人员”“严谨性”“清晰性”“应用性”“编撰的独立性”的平均得分分别为68%,35%,12%,79%,23%,52%,2部指南推荐级别为A级,5部指南推荐级别为B级,12部指南推荐级别为C级。结论CHB管理指南总体质量不高。有待开发可信赖的、高质量的CHB管理指南,尤其在“严谨性”和“应用性”方面需要进一步提高。展开更多
目的:探讨多囊卵巢综合征(PCOS)不孕患者肠道菌群分布与血清性激素、促甲状腺激素(TSH)及脂肪因子内脏脂肪特异性丝氨酸蛋白酶抑制剂(Vaspin)、Apelin的关系。方法:回顾性收集2019年1月-2022年1月本院诊治的PCOS不孕患者82例为PCOS组,...目的:探讨多囊卵巢综合征(PCOS)不孕患者肠道菌群分布与血清性激素、促甲状腺激素(TSH)及脂肪因子内脏脂肪特异性丝氨酸蛋白酶抑制剂(Vaspin)、Apelin的关系。方法:回顾性收集2019年1月-2022年1月本院诊治的PCOS不孕患者82例为PCOS组,因输卵管异常所致不孕女性82例为对照组。检测并比较两组肠道菌群含量、促黄体生成素(LH)、睾酮(T)、TSH、促卵泡素(FSH)、雌二醇(E_(2))及Vaspin、Apelin水平,分析PCOS组肠道菌群与血清性激素及Vaspin、Apelin的相关性。结果:PCOS组肠道双歧杆菌(8.64±0.82 lg CFU/g)、乳酸杆菌(9.22±0.84 lg CFU/g)低于对照组(9.92±0.94 lg CFU/g、9.89±0.90 lg CFU/g),肠球菌(8.25±0.79 lg CFU/g)、肠杆菌(9.14±0.87 lg CFU/g)及血清LH、T、E_(2)、FSH、TSH、Vaspin、Apelin水平均高于对照组(7.08±0.67 lg CFU/g、7.21±0.69 lg CFU/g)(均P<0.05);PCOS组双歧杆菌、乳酸杆菌与血清LH、T、TSH、Vaspin、Apelin呈负相关,肠球菌、肠杆菌与LH、T、TSH、Vaspin、Apelin呈正相关(均P<0.05)。结论:PCOS不孕患者肠道菌群失调,且与LH、T、TSH及Vaspin、Apelin均具相关性。展开更多
It is tangible that big shareholders infringe the interests of small and medium shareholders in China's listed companies,and such behaviors of big shareholders influence not only the normal production and business...It is tangible that big shareholders infringe the interests of small and medium shareholders in China's listed companies,and such behaviors of big shareholders influence not only the normal production and business operation of companies but also the sound development of the capital market. At the same time,the economic order of society is also disturbed. Therefore,expropriation of big shareholders shall be governed effectively in time. This paper tries to analyze related research findings on expropriation and make conclusion from three aspects—the ways of expropriation,economic consequences of expropriation and the management effects of expropriation,pointing out the limitation of present research and the direction for the future.展开更多
As one of the external mechanisms to protect investors,the quality of CPA auditing influences the profit of the investor directly.This paper studies the A-share listed companies in China from2009to 2011,with logistic ...As one of the external mechanisms to protect investors,the quality of CPA auditing influences the profit of the investor directly.This paper studies the A-share listed companies in China from2009to 2011,with logistic regression,re-evaluating and exploring the influence factors to the auditing quality of CPA from the perspectives of the size of accountant firms and the profit management level.It finds that the size of accountant firms and the auditing quality are positively correlated with each other,but the statistics are not significant;however,the profit management level influences the auditing quality significantly.Besides,this paper finds that compared with the small-sized accountant firms,the profit management level and the auditing quality of those big-sized accountant firms are correlated with each more significantly.展开更多
文摘目的利用指南研究与评价工具Ⅱ(AGREEⅡ)系统评价国内外最新版本的慢性乙型肝炎(CHB)管理指南,以促进高质量的指南应用于临床,并推动低质量指南的不断改进。方法检索中国知网(CNKI)、万方数据库、维普、SinoMed、PubMed、Embase、CocraneLibrary、Web of Science等数据库,以及中国临床指南文库(China Guideline Clearinghouse,CGC)、医脉通临床指南网、美国国家临床指南数据库(National Guideline Clearinghouse,NGC)、国际指南协作网(Guidelines International Network,GIN)、英国国家临床优化研究所(National Institute for Clinical Excellence,NICE)、苏格兰学院间指南网络(Scottish Inter-Academic Guide Network,SIGN)、澳大利亚临床实践指南(Australian Clinical Practice Guidelines,ACPG)等官方网站,补充检索谷歌学术、百度学术,搜集近10年CHB管理的相关指南,检索时限为2011年1月1日至2020年12月31日。利用AGREEⅡ评价指南的方法学质量,并比较纳入的指南在CHB抗病毒适应证的不同。结果共纳入指南19部。6个评价领域中,“范围与目的”“参与人员”“严谨性”“清晰性”“应用性”“编撰的独立性”的平均得分分别为68%,35%,12%,79%,23%,52%,2部指南推荐级别为A级,5部指南推荐级别为B级,12部指南推荐级别为C级。结论CHB管理指南总体质量不高。有待开发可信赖的、高质量的CHB管理指南,尤其在“严谨性”和“应用性”方面需要进一步提高。
文摘目的:探讨多囊卵巢综合征(PCOS)不孕患者肠道菌群分布与血清性激素、促甲状腺激素(TSH)及脂肪因子内脏脂肪特异性丝氨酸蛋白酶抑制剂(Vaspin)、Apelin的关系。方法:回顾性收集2019年1月-2022年1月本院诊治的PCOS不孕患者82例为PCOS组,因输卵管异常所致不孕女性82例为对照组。检测并比较两组肠道菌群含量、促黄体生成素(LH)、睾酮(T)、TSH、促卵泡素(FSH)、雌二醇(E_(2))及Vaspin、Apelin水平,分析PCOS组肠道菌群与血清性激素及Vaspin、Apelin的相关性。结果:PCOS组肠道双歧杆菌(8.64±0.82 lg CFU/g)、乳酸杆菌(9.22±0.84 lg CFU/g)低于对照组(9.92±0.94 lg CFU/g、9.89±0.90 lg CFU/g),肠球菌(8.25±0.79 lg CFU/g)、肠杆菌(9.14±0.87 lg CFU/g)及血清LH、T、E_(2)、FSH、TSH、Vaspin、Apelin水平均高于对照组(7.08±0.67 lg CFU/g、7.21±0.69 lg CFU/g)(均P<0.05);PCOS组双歧杆菌、乳酸杆菌与血清LH、T、TSH、Vaspin、Apelin呈负相关,肠球菌、肠杆菌与LH、T、TSH、Vaspin、Apelin呈正相关(均P<0.05)。结论:PCOS不孕患者肠道菌群失调,且与LH、T、TSH及Vaspin、Apelin均具相关性。
基金the phased achievement of the fund program of basic scientific research business expenses of Jilin University(No.:2011ZZ033)
文摘It is tangible that big shareholders infringe the interests of small and medium shareholders in China's listed companies,and such behaviors of big shareholders influence not only the normal production and business operation of companies but also the sound development of the capital market. At the same time,the economic order of society is also disturbed. Therefore,expropriation of big shareholders shall be governed effectively in time. This paper tries to analyze related research findings on expropriation and make conclusion from three aspects—the ways of expropriation,economic consequences of expropriation and the management effects of expropriation,pointing out the limitation of present research and the direction for the future.
基金the phased achievement of the fund program of basic scientific research business expenses of Jilin University(No.:2011ZZ033)
文摘As one of the external mechanisms to protect investors,the quality of CPA auditing influences the profit of the investor directly.This paper studies the A-share listed companies in China from2009to 2011,with logistic regression,re-evaluating and exploring the influence factors to the auditing quality of CPA from the perspectives of the size of accountant firms and the profit management level.It finds that the size of accountant firms and the auditing quality are positively correlated with each other,but the statistics are not significant;however,the profit management level influences the auditing quality significantly.Besides,this paper finds that compared with the small-sized accountant firms,the profit management level and the auditing quality of those big-sized accountant firms are correlated with each more significantly.
