目的描述局部晚期食管鳞癌术后恢复预期肿瘤治疗(return to intended oncologic therapy,RIOT)的特点,并调查其与总生存(overall survival,OS)的关系。方法回顾性分析2015年4月至2017年8月四川省肿瘤医院的600例行单纯根治性三切口(McKe...目的描述局部晚期食管鳞癌术后恢复预期肿瘤治疗(return to intended oncologic therapy,RIOT)的特点,并调查其与总生存(overall survival,OS)的关系。方法回顾性分析2015年4月至2017年8月四川省肿瘤医院的600例行单纯根治性三切口(McKeown)或两切口(Ivor-Lewis)食管切除手术或食管切除手术加术后化疗的局部晚期食管鳞癌患者的临床资料。RIOT定义为RIOT比例(接受了预期的术后化疗患者的比例)和RIOT时间(手术至术后化疗开始的时间)。采用KaplanMeier法作生存曲线。采用log-rank检验比较术后接受或不接受化疗患者的OS。使用Cox回归模型评估是否进行RIOT和开始RIOT周数的预后。结果337例患者接受了手术加术后化疗,RIOT比例为56.2%。接受微创食管切除术患者和接受开放食管切除术患者的RIOT比例比较,差异无统计学意义[57.4%(232/404)vs 53.6%(105/196),P=0.37]。术后未接受化疗患者的死亡风险高于接受化疗的患者(HR=1.64,95%CI:1.22~2.21,P<0.01)。228例明确了术后化疗开始的日期,其中位RIOT时间为43 d。微创食管切除术和开放食管切除术患者的中位RIOT时间比较,差异无统计学意义(42 d vs 45 d,P=0.95)。RIOT时间每延迟1周,患者的死亡风险增加9%(HR=1.09,95%CI:1.02~1.15,P=0.01)。结论局部晚期食管鳞癌行微创手术和开放手术的RIOT无明显区别。更早的RIOT时间与更好的OS相关。展开更多
Marxist theory is an im portant so urce of socialism core value theory,and building so cialism core values under the guidance of Marxist theory is a major proposition that must be considered in the ideological and pol...Marxist theory is an im portant so urce of socialism core value theory,and building so cialism core values under the guidance of Marxist theory is a major proposition that must be considered in the ideological and political education of the new era.Based on the Marxist materialist conception of history,this paper analyzed,from the Marxist perspective,the dialectical relationship between the free and full developm ent of people,the value of peo ple and social development,pointed out the existing problems in ideological and political education and the necessity of targeted education of the core values for teenagers,and proposed to develop and innovate the ways and methods of ideological and political education as well as carry out extensive education on the Marxism,socialism patriotism and Chinese traditional culture under the guidance of Marxist theory,for the purpose of helping teenagers build socialism core values and strengthen their faith in the socialist road with Chinese characteristics and the ideals and beliefs of communism.展开更多
文摘目的描述局部晚期食管鳞癌术后恢复预期肿瘤治疗(return to intended oncologic therapy,RIOT)的特点,并调查其与总生存(overall survival,OS)的关系。方法回顾性分析2015年4月至2017年8月四川省肿瘤医院的600例行单纯根治性三切口(McKeown)或两切口(Ivor-Lewis)食管切除手术或食管切除手术加术后化疗的局部晚期食管鳞癌患者的临床资料。RIOT定义为RIOT比例(接受了预期的术后化疗患者的比例)和RIOT时间(手术至术后化疗开始的时间)。采用KaplanMeier法作生存曲线。采用log-rank检验比较术后接受或不接受化疗患者的OS。使用Cox回归模型评估是否进行RIOT和开始RIOT周数的预后。结果337例患者接受了手术加术后化疗,RIOT比例为56.2%。接受微创食管切除术患者和接受开放食管切除术患者的RIOT比例比较,差异无统计学意义[57.4%(232/404)vs 53.6%(105/196),P=0.37]。术后未接受化疗患者的死亡风险高于接受化疗的患者(HR=1.64,95%CI:1.22~2.21,P<0.01)。228例明确了术后化疗开始的日期,其中位RIOT时间为43 d。微创食管切除术和开放食管切除术患者的中位RIOT时间比较,差异无统计学意义(42 d vs 45 d,P=0.95)。RIOT时间每延迟1周,患者的死亡风险增加9%(HR=1.09,95%CI:1.02~1.15,P=0.01)。结论局部晚期食管鳞癌行微创手术和开放手术的RIOT无明显区别。更早的RIOT时间与更好的OS相关。
基金the periodic research result of the project“Research on the Construction of Marxist Popular Carrier”(Project No.15SQWT16)commissioned by the Central Bureau of Compiler。
文摘Marxist theory is an im portant so urce of socialism core value theory,and building so cialism core values under the guidance of Marxist theory is a major proposition that must be considered in the ideological and political education of the new era.Based on the Marxist materialist conception of history,this paper analyzed,from the Marxist perspective,the dialectical relationship between the free and full developm ent of people,the value of peo ple and social development,pointed out the existing problems in ideological and political education and the necessity of targeted education of the core values for teenagers,and proposed to develop and innovate the ways and methods of ideological and political education as well as carry out extensive education on the Marxism,socialism patriotism and Chinese traditional culture under the guidance of Marxist theory,for the purpose of helping teenagers build socialism core values and strengthen their faith in the socialist road with Chinese characteristics and the ideals and beliefs of communism.
基金the periodic research result of the project"Research on the Construction of Marxist Popular Carrier"(Project No.:15SQWT16)commissioned by the Central Bureau of Compiler
文摘Xi Jinping's Thought on Youth Values and Its Guidance to Contemporary
