Clinical and pathological correlation of the microdeletion of Y chromosome for the 30 patients with azoospermia and severe oligoasthenospermia

Aim: To review the accumulated 30 patients with different area of Y chromosome microdeletions, focus-ing on their correlation with the clinical and pathological findings. Methods: A total of 334 consecutive infertile men with azoospermia (218 patients) and severe oligoasthenospermia (116 patients) were screened. Complete physical and endocrinological examinations, general chromosome study and multiplex polymerase chain reaction assay to evaluate the Y chromosome microdeletion were performed. Ten patients received testicular biopsy. Then the clinical and pathological findings were analyzed with reference to the areas of Y chromosome microdeletion. Results: There is a decline of the percentage of sperm appearing in semen in the group that the gene deletion region from AZFc to AZFb. The clinical evidence of the impairment (decreased testicular size and elevated serum FSH) is also relevantly aggravated in this group. However, the pathology of testicular biopsy specimen was poorly correlated with the different deletion areas of the Y chromosome, which may be due to the limited number of specimens. Conclusion:The clinical correlation of spermatogenic impairment to the different AZF deletion regions may provide the information for the infertile couples in pre-treatment counseling. (Asian JAndrol 2004 Dec; 6:369-375)

Efficacy and safety of on demand tadalafil in the treatment of East and Southeast Asian men with erectile dysfunction:a randomized double-blind,parallel,placebo-controlled clinical study

瞄准：与安慰剂相比估计 tadalafil 的功效和安全，当与可勃起的机能障碍(编辑) 由东方 / 东南亚洲人呈现对 12 个星期的需求时。方法：这多集中，使随机化，双窗帘，平行的组，控制安慰剂的学习越过在 2002 年 8 月和 2003 年 2 月之间的东方和东南亚洲在 17 个中心被进行。人们超过 18 岁与对各种各样的病原学的严重编辑温和被使随机化收到安慰剂或是需要拿的 tadalafil 的 20 mg (最大从前每日) 。功效评价包括了可勃起的功能，性相遇侧面日记和全球评价问题的国际索引。结果：Tadalafil 显著地作为与安慰剂相比改进了可勃起的功能(P 【 0.001 ) 。在端点，收到 tadalafil 的 20 mg 的病人每成功的交际尝试的耐心的百分比报导了一个更大的平均数(性相遇侧面问题 3：70.9% 与 33.5% 相比在安慰剂) 并且改进勃起的一个更大的比例(全球评价问题：86.2% 与 30.1% 相比) 。大多数(=/【3%) 治疗突现的不利事件温和或中等。最普通的治疗突现的不利事件是头疼，背疼痛，头昏和消化不良。结论：Tadalafil 是为在东方和东南亚洲人男人的编辑的有效、容忍得好的治疗。

Efficacy and safety of tadalafil taken as needed for the treatment of erectile dysfunction in Asian men： results of an integrated analysis

我们在一张多样的临床的人口评估了同样需要的 tadalafil 的功效和安全(与改变耐心的人口分布，疾病严厉，和 comorbid 医药条件) 有可勃起的机能障碍(编辑) 的亚洲人。五双窗帘的综合分析，控制安慰剂的试用(N = 1 046 ) 被执行。病人们随机被分配收到 10 mg tadalafil (N = 185 ) ， 20 mg tadalafil (N = 510 ) ，或安慰剂(N = 351 ) 。功效评价包括了可勃起的功能(IIEF ) 的国际索引，性相遇侧面(9 月) 日记和全球评价问题(GAQ ) 。收到 10 mg 或 20 mg tadalafil 从 baseline-to-end 看了重要改进的病人指在在分析的所有临床的亚人口的可勃起的功能(IIEF-EF ) 领域 20 的国际索引的可勃起的功能领域上，与收到安慰剂的病人相比(P < 0.001 ) 。给吝啬的成功看的 10-mg 和 20-mg tadalafil 组为性交尝试64.1%和70.5%评价( SEP3 ，成功的性交)分别地，在安慰剂与33.4%相比组织( P < 0.001 )，并且分别地，在结束的85.5%和85.4%报导改进勃起削尖 GAQ 对43.5%在安慰剂组织( P < 0.001 )。Tadalafil 很好越过学习的所有组被容忍。头疼和背疼痛是最经常报导的不利事件。总的来说， tadalafil 越过有编辑的亚洲男人的一个多样的临床的系列有效、很好容忍。