The ability to tune the size, shape, composition and surface properties impart nanoparticles with the desired functions for bio-application. This article highlights some of the recent examples in the exploration of me...The ability to tune the size, shape, composition and surface properties impart nanoparticles with the desired functions for bio-application. This article highlights some of the recent examples in the exploration of metal （e.g., gold and silver） nanoparticles, especially those with magnetic properties and bio-conjugated structures, as theranostic nanoprobes. Such nanoprobes exhibit tunable optical, spectroscopic, magnetic, and electrical properties for signal amplifications. Examples discussed in this article will focus on the nanoproble-enhanced colorimetric detection and surface enhanced Raman scattering （SERS） detection of biomarkers or biomolecules such as proteins and DNAs. The understanding of factors controlling the biomolecular interactions is essential for the design of SERS nanoprobes with theranostic functions.展开更多
基金Acknowledgements The authors express our appreciations to former and current members of the Zhong Research Group and collaborators who have made contributions to the work described in this article. Portions of the research are supported by the National Natural Science Foundation （Grant Nos. 0848701, 1100736） and SUNY Research Collaboration Fund, and in part by the Scientific Research Foundation of SIT （YJ2015-9） and SEC （ZZyy15099）.
文摘The ability to tune the size, shape, composition and surface properties impart nanoparticles with the desired functions for bio-application. This article highlights some of the recent examples in the exploration of metal （e.g., gold and silver） nanoparticles, especially those with magnetic properties and bio-conjugated structures, as theranostic nanoprobes. Such nanoprobes exhibit tunable optical, spectroscopic, magnetic, and electrical properties for signal amplifications. Examples discussed in this article will focus on the nanoproble-enhanced colorimetric detection and surface enhanced Raman scattering （SERS） detection of biomarkers or biomolecules such as proteins and DNAs. The understanding of factors controlling the biomolecular interactions is essential for the design of SERS nanoprobes with theranostic functions.
