Aim:Hepatocellular carcinoma(HCC)is the dominant form of primary liver cancer and is histologically and etiologically distinct from other forms of primary liver cancer.The objective of this study was to elucidate the ...Aim:Hepatocellular carcinoma(HCC)is the dominant form of primary liver cancer and is histologically and etiologically distinct from other forms of primary liver cancer.The objective of this study was to elucidate the synergistic effect and the role of chicory extract[inulin(IN)]as a chemo-sensitizer for cisplatin(CIS)treatment of HCC.Methods:Five groups of rats were treated for 4 months.These groups consisted of the control group,a group receiving thioacetamide(TAA)(200 mg/kg b.w)in drinking water,a group injected intraperitoneally with a single dose of CIS(7.5 mg/kg b.w)in addition to TAA for 4 months,a group receiving oral doses of IN(10 mg/kg b.w)in addition to TAA for 4 months,and a group injected intraperitoneally with a single dose of CIS(7.5 mg/kg b.w)and IN(10 mg/kg b.w)plus TAA for 4 months.Results:The current data exhibited increment of serum and liver enzyme(alanine aminotransferase,aspartate aminotransferase,alkaline phosphatase,creatine kinase,and lactate dehydrogenase)activity,serum lipid profi le levels(total lipids,total cholesterol,triglycerides,low-density lipoprotein,and very low-density lipoprotein),and a signifi cant increase inα-fetoprotein and bilirubin,accompanied with reduced total serum protein and albumin levels in a HCC rat model.Histopathologically,numerous alterations were detected in hepatic tissues of HCC rats,such as lymphocytic cell infi ltration,damage of hepatocytes,dilated congested central vein with degenerated endothelial cells,and congested blood sinusoids in addition to Masson’s trichrome staining blue collagen fi bers in hepatocytes and central vein indicating hepatic fi brosis.Treatment of HCC rats with CIS or IN improved such deleterious effects,where IN is more effective than CIS,and the best effect can be observed in rats that received both CIS and IN.Conclusion:It could be concluded that IN in chicory extract acts as a chemo-sensitizer to CIS for treatment in an HCC rat model.展开更多
Hepatocellular carcinoma(HCC)is a growing health problem in humans.HCC is considered the most common of internal malignancy which cause the death of human,but in the developed Western world,HCC is less common accompan...Hepatocellular carcinoma(HCC)is a growing health problem in humans.HCC is considered the most common of internal malignancy which cause the death of human,but in the developed Western world,HCC is less common accompanied by increasing essentially in incidence,due to it occurs specially in chronic liver disease.HCC associated with various risk factors including hepatitis B virus infection;hepatitis C virus infection;prolonged aflatoxin exposure;and alcoholic cirrhosis.Overall,one-third of cirrhosis patients will develop HCC during their life time.Also,chemical carcinogens cause tumor promotions through free radical metabolites result in many biochemical and molecular changes that induces oxidative stress.The identify of HCC stage and underlying liver status then choosing the most appropriate line of therapy(surgical,loco regional,radiological and medical)can be improve the survival and/or the quality of life of the patient.Taken into the account of the nutritional value of some natural antioxidant agents that support the function of the body resulting an improvement of the health and protection from different diseases,our review will provide an up-dated status of the different aspects of HCC management through covering the efficacy and the beneficial effects of different natural agents and their mechanism of action against HCC for the future therapy modalities.展开更多
文摘Aim:Hepatocellular carcinoma(HCC)is the dominant form of primary liver cancer and is histologically and etiologically distinct from other forms of primary liver cancer.The objective of this study was to elucidate the synergistic effect and the role of chicory extract[inulin(IN)]as a chemo-sensitizer for cisplatin(CIS)treatment of HCC.Methods:Five groups of rats were treated for 4 months.These groups consisted of the control group,a group receiving thioacetamide(TAA)(200 mg/kg b.w)in drinking water,a group injected intraperitoneally with a single dose of CIS(7.5 mg/kg b.w)in addition to TAA for 4 months,a group receiving oral doses of IN(10 mg/kg b.w)in addition to TAA for 4 months,and a group injected intraperitoneally with a single dose of CIS(7.5 mg/kg b.w)and IN(10 mg/kg b.w)plus TAA for 4 months.Results:The current data exhibited increment of serum and liver enzyme(alanine aminotransferase,aspartate aminotransferase,alkaline phosphatase,creatine kinase,and lactate dehydrogenase)activity,serum lipid profi le levels(total lipids,total cholesterol,triglycerides,low-density lipoprotein,and very low-density lipoprotein),and a signifi cant increase inα-fetoprotein and bilirubin,accompanied with reduced total serum protein and albumin levels in a HCC rat model.Histopathologically,numerous alterations were detected in hepatic tissues of HCC rats,such as lymphocytic cell infi ltration,damage of hepatocytes,dilated congested central vein with degenerated endothelial cells,and congested blood sinusoids in addition to Masson’s trichrome staining blue collagen fi bers in hepatocytes and central vein indicating hepatic fi brosis.Treatment of HCC rats with CIS or IN improved such deleterious effects,where IN is more effective than CIS,and the best effect can be observed in rats that received both CIS and IN.Conclusion:It could be concluded that IN in chicory extract acts as a chemo-sensitizer to CIS for treatment in an HCC rat model.
文摘Hepatocellular carcinoma(HCC)is a growing health problem in humans.HCC is considered the most common of internal malignancy which cause the death of human,but in the developed Western world,HCC is less common accompanied by increasing essentially in incidence,due to it occurs specially in chronic liver disease.HCC associated with various risk factors including hepatitis B virus infection;hepatitis C virus infection;prolonged aflatoxin exposure;and alcoholic cirrhosis.Overall,one-third of cirrhosis patients will develop HCC during their life time.Also,chemical carcinogens cause tumor promotions through free radical metabolites result in many biochemical and molecular changes that induces oxidative stress.The identify of HCC stage and underlying liver status then choosing the most appropriate line of therapy(surgical,loco regional,radiological and medical)can be improve the survival and/or the quality of life of the patient.Taken into the account of the nutritional value of some natural antioxidant agents that support the function of the body resulting an improvement of the health and protection from different diseases,our review will provide an up-dated status of the different aspects of HCC management through covering the efficacy and the beneficial effects of different natural agents and their mechanism of action against HCC for the future therapy modalities.
