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Structure and function of the membrane microdomains in osteoclasts
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作者 Jialong Hou Jian Liu +6 位作者 Zhixian Huang Yining Wang hanbing yao Zhenxin Hu Chengge Shi Jiake Xu Qingqing Wang 《Bone Research》 SCIE CAS CSCD 2023年第4期665-678,共14页
The cell membrane structure is closely related to the occurrence and progression of many metabolic bone diseases observed in the clinic and is an important target to the development of therapeutic strategies for these... The cell membrane structure is closely related to the occurrence and progression of many metabolic bone diseases observed in the clinic and is an important target to the development of therapeutic strategies for these diseases.Strong experimental evidence supports the existence of membrane microdomains in osteoclasts(OCs).However,the potential membrane microdomains and the crucial mechanisms underlying their roles in OCs have not been fully characterized.Membrane microdomain components,such as scaffolding proteins and the actin cytoskeleton,as well as the roles of individual membrane proteins,need to be elucidated.In this review,we discuss the compositions and critical functions of membrane microdomains that determine the biological behavior of OCs through the three main stages of the OC life cycle. 展开更多
关键词 DOMAINS FUNCTION elucidated
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