Intracranial hemorrhage(ICH)causes numerous neurological deficits and deaths worldwide each year,leaving a significant health burden on the public.The pathophysiology of ICH is complicated and involves both primary an...Intracranial hemorrhage(ICH)causes numerous neurological deficits and deaths worldwide each year,leaving a significant health burden on the public.The pathophysiology of ICH is complicated and involves both primary and secondary injuries.Hematoma,as the primary pathology of ICH,undergoes metabolism and triggers biochemical and biomechanical alterations in the brain,leading to the secondary injury.Past endeavors mainly aimed at biochemical-initiated mechanisms for causing secondary injury,which have made limited progress in recent years,although ICH itself is also highly biomechanics-related.The discovery of the mechanically-activated cation channel Piezo1 provides a new avenue to further explore the mechanisms underlying the secondary injury.The current article reviews the structure and gating mechanisms of Piezo1,its roles in the physiology/pathophysiology of neurons,astrocytes,microglia,and bone-marrow-derived macrophages,and especially its roles in erythrocytic turnover and iron metabolism,revealing a potential interplay between the biomechanics and biochemistry of hematoma in ICH.Collectively,these advances provide deeper insights into the secondary injury of ICH and lay the foundations for future research.展开更多
目的评估中国新诊断胶质母细胞瘤(glioblastoma multiforme,GBM)患者实际接受的治疗方案与指南推荐的Stupp方案的一致性。方法纳入202例新诊断GBM患者,评估实际接受的治疗方案与Stupp方案一致的患者比例,以及不符合Stupp方案的原因。结...目的评估中国新诊断胶质母细胞瘤(glioblastoma multiforme,GBM)患者实际接受的治疗方案与指南推荐的Stupp方案的一致性。方法纳入202例新诊断GBM患者,评估实际接受的治疗方案与Stupp方案一致的患者比例,以及不符合Stupp方案的原因。结果研究发现,仅15.8%的GBM患者接受了与Stupp方案一致的治疗。治疗方案的不一致主要是由于同步放化疗阶段替莫唑胺剂量>75 mg/m^(2)(58/120;48.3%)和治疗持续时间<42 d(84/120;70.0%),以及辅助治疗阶段替莫唑胺剂量<150 mg/m^(2)(89/101;88.1%)。接受符合Stupp方案治疗的患者的中位总生存期(27.09 vs 18.21个月)和无进展生存期(14.27 vs 12.10个月)更长。结论需要提高中国GBM患者实际接受的治疗方案与Stupp方案的一致性。展开更多
Many studies have been carried out using vehicle trajectory to analyze traffic conditions, for instance, identifying traffic congestion. However, there is a lack of a systematic study on the appropriate number of prob...Many studies have been carried out using vehicle trajectory to analyze traffic conditions, for instance, identifying traffic congestion. However, there is a lack of a systematic study on the appropriate number of probe vehicles and their sampling interval in order to identify traffic congestion accurately. Moreover, most of related studies ignore the streaming feature of trajectory data. This paper first represents a novel method of identifying traffic congestion considering the stream feature of vehicle trajectories. Instead of processing the whole data stream, a series of snapshots are extracted. Congested road segments can be identified by analyzing the clusters＇ evolution among a series of adjacent snapshots. We then calculated a series of parameters and their corresponding congestion identification accuracy. The results have implications for related probe vehicle deployment and traffic analysis; for example, when 5% of probe vehicles are available, 85% identification accuracy can be reached if the sampling time interval is 10 s.展开更多
基金supported by the National Natural Science Foundation of China(Grant No.82271426).
文摘Intracranial hemorrhage(ICH)causes numerous neurological deficits and deaths worldwide each year,leaving a significant health burden on the public.The pathophysiology of ICH is complicated and involves both primary and secondary injuries.Hematoma,as the primary pathology of ICH,undergoes metabolism and triggers biochemical and biomechanical alterations in the brain,leading to the secondary injury.Past endeavors mainly aimed at biochemical-initiated mechanisms for causing secondary injury,which have made limited progress in recent years,although ICH itself is also highly biomechanics-related.The discovery of the mechanically-activated cation channel Piezo1 provides a new avenue to further explore the mechanisms underlying the secondary injury.The current article reviews the structure and gating mechanisms of Piezo1,its roles in the physiology/pathophysiology of neurons,astrocytes,microglia,and bone-marrow-derived macrophages,and especially its roles in erythrocytic turnover and iron metabolism,revealing a potential interplay between the biomechanics and biochemistry of hematoma in ICH.Collectively,these advances provide deeper insights into the secondary injury of ICH and lay the foundations for future research.
基金This study was approved by the Ethics Committee of the Peking Union Medical College Hospital,China(EC No.:S-473).Written informed consent was obtained from all patients prior to enrollment.
文摘目的评估中国新诊断胶质母细胞瘤(glioblastoma multiforme,GBM)患者实际接受的治疗方案与指南推荐的Stupp方案的一致性。方法纳入202例新诊断GBM患者,评估实际接受的治疗方案与Stupp方案一致的患者比例,以及不符合Stupp方案的原因。结果研究发现,仅15.8%的GBM患者接受了与Stupp方案一致的治疗。治疗方案的不一致主要是由于同步放化疗阶段替莫唑胺剂量>75 mg/m^(2)(58/120;48.3%)和治疗持续时间<42 d(84/120;70.0%),以及辅助治疗阶段替莫唑胺剂量<150 mg/m^(2)(89/101;88.1%)。接受符合Stupp方案治疗的患者的中位总生存期(27.09 vs 18.21个月)和无进展生存期(14.27 vs 12.10个月)更长。结论需要提高中国GBM患者实际接受的治疗方案与Stupp方案的一致性。
文摘Many studies have been carried out using vehicle trajectory to analyze traffic conditions, for instance, identifying traffic congestion. However, there is a lack of a systematic study on the appropriate number of probe vehicles and their sampling interval in order to identify traffic congestion accurately. Moreover, most of related studies ignore the streaming feature of trajectory data. This paper first represents a novel method of identifying traffic congestion considering the stream feature of vehicle trajectories. Instead of processing the whole data stream, a series of snapshots are extracted. Congested road segments can be identified by analyzing the clusters＇ evolution among a series of adjacent snapshots. We then calculated a series of parameters and their corresponding congestion identification accuracy. The results have implications for related probe vehicle deployment and traffic analysis; for example, when 5% of probe vehicles are available, 85% identification accuracy can be reached if the sampling time interval is 10 s.
