期刊文献+
共找到1篇文章
< 1 >
每页显示 20 50 100
Applanoids A—E as the First Examples of C-15/C-20 Michael Adducts in Ganoderma Triterpenoids and Their PXR Agonistic Activity 被引量:1
1
作者 Hai-Guo Su hang-fei liang +4 位作者 Gui-Lin Hu Lin Zhou Xing-Rong Peng Hui-Chang Bi Ming-Hua Qiu 《Chinese Journal of Chemistry》 SCIE CAS CSCD 2022年第22期2633-2641,共9页
Ganoderma triterpenoids(GTs),a class of major active constituents of Ganoderma fungi,possess diverse structures and remarkable activities.In the present study,nine new GTs,namely applanoids A—I(1—9),were isolated fr... Ganoderma triterpenoids(GTs),a class of major active constituents of Ganoderma fungi,possess diverse structures and remarkable activities.In the present study,nine new GTs,namely applanoids A—I(1—9),were isolated from the medicinal fungus of Ganoderma applanatum.Their structures including absolute configurations were established by comprehensive spectroscopic analyses and ECD calculation.Applanoids A—E(1—5)represent the first example of GTs with 6/6/5/6/5 pentacyclic system and the formation of the ether ring between C-15 and C-20 involves Michael addition reaction.Furthermore,compounds 1—8 were evaluated for their human pregnane X receptor(hPXR)agonistic activity using dual-luciferase reporter gene assay,and the results showed that compounds 1,2 and 4 can dose-dependently activate hPXR.This investigation further illustrated the structural diversity of GTs and provided new insights for searching PXR agonists from GTs. 展开更多
关键词 Ganoderma applanatum Lanostane triterpenoids Michael adducts Structure elucidation Pregnane X receptor
原文传递
上一页 1 下一页 到第
使用帮助 返回顶部