The escalating deployment of distributed power sources and random loads in DC distribution networks hasamplified the potential consequences of faults if left uncontrolled. To expedite the process of achieving an optim...The escalating deployment of distributed power sources and random loads in DC distribution networks hasamplified the potential consequences of faults if left uncontrolled. To expedite the process of achieving an optimalconfiguration of measurement points, this paper presents an optimal configuration scheme for fault locationmeasurement points in DC distribution networks based on an improved particle swarm optimization algorithm.Initially, a measurement point distribution optimization model is formulated, leveraging compressive sensing.The model aims to achieve the minimum number of measurement points while attaining the best compressivesensing reconstruction effect. It incorporates constraints from the compressive sensing algorithm and networkwide viewability. Subsequently, the traditional particle swarm algorithm is enhanced by utilizing the Haltonsequence for population initialization, generating uniformly distributed individuals. This enhancement reducesindividual search blindness and overlap probability, thereby promoting population diversity. Furthermore, anadaptive t-distribution perturbation strategy is introduced during the particle update process to enhance the globalsearch capability and search speed. The established model for the optimal configuration of measurement points issolved, and the results demonstrate the efficacy and practicality of the proposed method. The optimal configurationreduces the number of measurement points, enhances localization accuracy, and improves the convergence speedof the algorithm. These findings validate the effectiveness and utility of the proposed approach.展开更多
The force chain is the core of the multi-scale analysis of granular matter.Accurately extracting the force chain information among particles is of great significance to the study of particle mechanics and geological h...The force chain is the core of the multi-scale analysis of granular matter.Accurately extracting the force chain information among particles is of great significance to the study of particle mechanics and geological hazards caused by particle flow.However,in the photoelastic experiment,the precise identification of the branching points of force chains has not been effectively realized.Therefore,this study proposes an automatic extraction method of force chain key information.First,based on the Hough transform and the Euclidean distance,a particle geometric information identification model is established and geometric information such as particle circle center coordinates,radius,contact point location,and contact angle is extracted.Then,a particle contact force information identification model is established following the color gradient mean square method.The model realizes the rapid calibration and extraction of a large number of particle media contact force information.Next,combined with the force chain composition criterion and its quasilinear feature,an automatic extraction method of force chain information is established,which solves the problem of the accurate identification of the force chain branch points.Finally,in the photoelastic experiment of ore drawing from a single drawpoint,the automatic extraction method of force chain information is verified.The results show that the macroscopic distribution of force chains during ore drawing from a single drawpoint is left–right symmetrical.Strong force chains are mostly located on the two sides of the model but in small numbers and they mainly develop vertically.Additionally,the ends are mostly in a combination of Y and inverted Y shapes,while the middle is mostly quasilinear.Weak force chains are abundant and mostly distributed in the middle of the model,and develop in different directions.The proposed extraction method accurately extracts the force chain network from the photoelastic experiment images and dynamically characterizes the force chains of granular matter,which has significant advantages in particle geometry information extraction,force chain branch point discrimination,force chain retrieval,and force chain distribution and its azimuthal characterization.The results provide a scientific basis for studying the macroscopic and microscopic mechanical parameters of granular matter.展开更多
Traveling wave piezoelectric beam actuators(TWPBAs)present an advantageous structural configuration for self-moving actuators and hold significant promise for operation in confined spaces.However,current research on T...Traveling wave piezoelectric beam actuators(TWPBAs)present an advantageous structural configuration for self-moving actuators and hold significant promise for operation in confined spaces.However,current research on TWPBAs faces several limitations,including deficient design methods of excitation and structural parameters,inadequate evaluation metrics,and lack of a quantitative relationship between these parameters and evaluation metrics.This study presents a systematic approach to determining TWPBAs'structure and excitation parameters,proposes criteria for determining the excitation parameters through an established analytical model,and introduces an effective evaluation method for TWPBAs'driving.Through the analytical model and evaluation metrics,we reveal:(1)the coupling relationship between excitation parameters and structural parameters,(2)the influence of participating mode pairs on vibration response,(3)the quantitative relationship between the evaluation metrics and excitation parameters is also revealed.These conclusions are substantiated by the results of finite element analysis,laser vibration measurements,and motion test experiments.Notably,the practical application of TWPBAs in pipeline operations underscores their potential for use in endoscopy and precision instruments.展开更多
Metamaterials can control incident waves in the sub-wavelength range through the design of artificial structures, and realize the functions that natural materials cannot achieve. The study of metamaterials has importa...Metamaterials can control incident waves in the sub-wavelength range through the design of artificial structures, and realize the functions that natural materials cannot achieve. The study of metamaterials has important theoretical value and application prospects. In recent years, the proposal of computational metamaterials has opened up a brand-new direction for analog computing, providing high-throughput, energy-free computing methods for special computing tasks. However, the development of acoustic computing metamaterials is relatively preliminary, and it is necessary to develop design theories. There is no work to solve partial differential equations and realize fractional Fourier transform in spatial domain acoustic computing metamaterials. In this paper, the acoustic wave computational metamaterial is designed, and the simulation realizes the spatial domain fractional Fourier transform and partial differential equation calculation. It is expected that acoustic computational metamaterials will enable new capabilities in signal acquisition and processing, network computing, and drive new applications of sound wave.展开更多
The advent of cancer immunotherapy has imparted a transformative impact on cancer treatment paradigms by harnessing the power of the immune system.However,the challenge of practical and precise targeting of malignant ...The advent of cancer immunotherapy has imparted a transformative impact on cancer treatment paradigms by harnessing the power of the immune system.However,the challenge of practical and precise targeting of malignant cells persists.To address this,engineered nanoparticles(NPs)have emerged as a promising solution for enhancing targeted drug delivery in immunotherapeutic interventions,owing to their small size,low immunogenicity,and ease of surface modification.This comprehensive review delves into contemporary research at the nexus of NP engineering and immunotherapy,encompassing an extensive spectrum of NP morphologies and strategies tailored toward optimizing tumor targeting and augmenting therapeutic effectiveness.Moreover,it underscores the mechanisms that NPs leverage to bypass the numerous obstacles encountered in immunotherapeutic regimens and probes into the combined potential of NPs when co-administered with both established and novel immunotherapeutic modalities.Finally,the review evaluates the existing limitations of NPs as drug delivery platforms in immunotherapy,which could shape the path for future advancements in this promising field.展开更多
基金the National Natural Science Foundation of China(52177074).
文摘The escalating deployment of distributed power sources and random loads in DC distribution networks hasamplified the potential consequences of faults if left uncontrolled. To expedite the process of achieving an optimalconfiguration of measurement points, this paper presents an optimal configuration scheme for fault locationmeasurement points in DC distribution networks based on an improved particle swarm optimization algorithm.Initially, a measurement point distribution optimization model is formulated, leveraging compressive sensing.The model aims to achieve the minimum number of measurement points while attaining the best compressivesensing reconstruction effect. It incorporates constraints from the compressive sensing algorithm and networkwide viewability. Subsequently, the traditional particle swarm algorithm is enhanced by utilizing the Haltonsequence for population initialization, generating uniformly distributed individuals. This enhancement reducesindividual search blindness and overlap probability, thereby promoting population diversity. Furthermore, anadaptive t-distribution perturbation strategy is introduced during the particle update process to enhance the globalsearch capability and search speed. The established model for the optimal configuration of measurement points issolved, and the results demonstrate the efficacy and practicality of the proposed method. The optimal configurationreduces the number of measurement points, enhances localization accuracy, and improves the convergence speedof the algorithm. These findings validate the effectiveness and utility of the proposed approach.
基金This work was supported by the National Natural Science Foundation of China(grant No.51964003)the Interdisciplinary Research Project of Guangxi University(grant No.2022JCB012).
文摘The force chain is the core of the multi-scale analysis of granular matter.Accurately extracting the force chain information among particles is of great significance to the study of particle mechanics and geological hazards caused by particle flow.However,in the photoelastic experiment,the precise identification of the branching points of force chains has not been effectively realized.Therefore,this study proposes an automatic extraction method of force chain key information.First,based on the Hough transform and the Euclidean distance,a particle geometric information identification model is established and geometric information such as particle circle center coordinates,radius,contact point location,and contact angle is extracted.Then,a particle contact force information identification model is established following the color gradient mean square method.The model realizes the rapid calibration and extraction of a large number of particle media contact force information.Next,combined with the force chain composition criterion and its quasilinear feature,an automatic extraction method of force chain information is established,which solves the problem of the accurate identification of the force chain branch points.Finally,in the photoelastic experiment of ore drawing from a single drawpoint,the automatic extraction method of force chain information is verified.The results show that the macroscopic distribution of force chains during ore drawing from a single drawpoint is left–right symmetrical.Strong force chains are mostly located on the two sides of the model but in small numbers and they mainly develop vertically.Additionally,the ends are mostly in a combination of Y and inverted Y shapes,while the middle is mostly quasilinear.Weak force chains are abundant and mostly distributed in the middle of the model,and develop in different directions.The proposed extraction method accurately extracts the force chain network from the photoelastic experiment images and dynamically characterizes the force chains of granular matter,which has significant advantages in particle geometry information extraction,force chain branch point discrimination,force chain retrieval,and force chain distribution and its azimuthal characterization.The results provide a scientific basis for studying the macroscopic and microscopic mechanical parameters of granular matter.
基金supported by the National Natural Science Foundation of China(Grant Nos.12025201,11890681,12102007).
文摘Traveling wave piezoelectric beam actuators(TWPBAs)present an advantageous structural configuration for self-moving actuators and hold significant promise for operation in confined spaces.However,current research on TWPBAs faces several limitations,including deficient design methods of excitation and structural parameters,inadequate evaluation metrics,and lack of a quantitative relationship between these parameters and evaluation metrics.This study presents a systematic approach to determining TWPBAs'structure and excitation parameters,proposes criteria for determining the excitation parameters through an established analytical model,and introduces an effective evaluation method for TWPBAs'driving.Through the analytical model and evaluation metrics,we reveal:(1)the coupling relationship between excitation parameters and structural parameters,(2)the influence of participating mode pairs on vibration response,(3)the quantitative relationship between the evaluation metrics and excitation parameters is also revealed.These conclusions are substantiated by the results of finite element analysis,laser vibration measurements,and motion test experiments.Notably,the practical application of TWPBAs in pipeline operations underscores their potential for use in endoscopy and precision instruments.
基金This work was supported by the National Natural Science Foundation of China(Grants 12025201,11521202,11890681,and 11522214)Calculations are supported by High-Performance Computing Platform of Peking University,China.
文摘Metamaterials can control incident waves in the sub-wavelength range through the design of artificial structures, and realize the functions that natural materials cannot achieve. The study of metamaterials has important theoretical value and application prospects. In recent years, the proposal of computational metamaterials has opened up a brand-new direction for analog computing, providing high-throughput, energy-free computing methods for special computing tasks. However, the development of acoustic computing metamaterials is relatively preliminary, and it is necessary to develop design theories. There is no work to solve partial differential equations and realize fractional Fourier transform in spatial domain acoustic computing metamaterials. In this paper, the acoustic wave computational metamaterial is designed, and the simulation realizes the spatial domain fractional Fourier transform and partial differential equation calculation. It is expected that acoustic computational metamaterials will enable new capabilities in signal acquisition and processing, network computing, and drive new applications of sound wave.
基金supported by grants from Karolinska Institute Network Medicine Global Alliance Collaborative Grant(C24401073,Sweden)China Postdoctoral Science Foundation(2021M703602)Natural Science Foundation of Liaoning Province(2022-BS-137,China).
文摘The advent of cancer immunotherapy has imparted a transformative impact on cancer treatment paradigms by harnessing the power of the immune system.However,the challenge of practical and precise targeting of malignant cells persists.To address this,engineered nanoparticles(NPs)have emerged as a promising solution for enhancing targeted drug delivery in immunotherapeutic interventions,owing to their small size,low immunogenicity,and ease of surface modification.This comprehensive review delves into contemporary research at the nexus of NP engineering and immunotherapy,encompassing an extensive spectrum of NP morphologies and strategies tailored toward optimizing tumor targeting and augmenting therapeutic effectiveness.Moreover,it underscores the mechanisms that NPs leverage to bypass the numerous obstacles encountered in immunotherapeutic regimens and probes into the combined potential of NPs when co-administered with both established and novel immunotherapeutic modalities.Finally,the review evaluates the existing limitations of NPs as drug delivery platforms in immunotherapy,which could shape the path for future advancements in this promising field.