Calotropisprocera(Cp)is a traditional medicinal plant that has attracted significant attention for its potential anticancer properties.This review consolidates current research on the Cp bioactive compounds found in C...Calotropisprocera(Cp)is a traditional medicinal plant that has attracted significant attention for its potential anticancer properties.This review consolidates current research on the Cp bioactive compounds found in Cp,including cardenolides,flavonoids,and terpenoids,which exhibit cytotoxic effects against various cancer cells.These compounds function through multiple mechanisms,such as inducing apoptosis,inhibiting cell proliferation,suppressing angiogenesis,and modulating oxidative stress.Preclinical studies demonstrate that Cp extracts effectively reduce tumor size and improve survival rates in animal models.Furthermore,Cp influences key signaling pathways like PI3K/Akt and NF-κB,which contribute to its anticancer potential.Its therapeutic effects extend beyond oncology,encompassing,antinociceptive,anticonvulsant,antimalarial,anthelmintic,antioxidant,antidiabetic,myocardial infarction prevention,schizontocidal,antimicrobial,anti-inflammatory,larvicidal,immunomodulatory,antiulcer,Antifertility,antidiarrheal,estrogenic,and Dermatophytic properties.Despite the promising preclinical data,further investigation is necessary to address challenges such as bioavailability,toxicity,and the standardization of Cp-based treatments.This review highlights the therapeutic promise of Cp as a complementary anticancer agent while emphasizing the need for rigorous clinical trials to confirm its safety and efficacy.展开更多
基金this manuscript sincerely acknowledge Central South University for their support through the postdoctoral research initiation grant(164990011).
文摘Calotropisprocera(Cp)is a traditional medicinal plant that has attracted significant attention for its potential anticancer properties.This review consolidates current research on the Cp bioactive compounds found in Cp,including cardenolides,flavonoids,and terpenoids,which exhibit cytotoxic effects against various cancer cells.These compounds function through multiple mechanisms,such as inducing apoptosis,inhibiting cell proliferation,suppressing angiogenesis,and modulating oxidative stress.Preclinical studies demonstrate that Cp extracts effectively reduce tumor size and improve survival rates in animal models.Furthermore,Cp influences key signaling pathways like PI3K/Akt and NF-κB,which contribute to its anticancer potential.Its therapeutic effects extend beyond oncology,encompassing,antinociceptive,anticonvulsant,antimalarial,anthelmintic,antioxidant,antidiabetic,myocardial infarction prevention,schizontocidal,antimicrobial,anti-inflammatory,larvicidal,immunomodulatory,antiulcer,Antifertility,antidiarrheal,estrogenic,and Dermatophytic properties.Despite the promising preclinical data,further investigation is necessary to address challenges such as bioavailability,toxicity,and the standardization of Cp-based treatments.This review highlights the therapeutic promise of Cp as a complementary anticancer agent while emphasizing the need for rigorous clinical trials to confirm its safety and efficacy.
