The authors regret<insert corrigendum text>.The cytoskeleton staining images in Fig.5(C)of the original manuscript overlap,as shown in the white dotted box below.Given this error,we re-supplement the relevant ex...The authors regret<insert corrigendum text>.The cytoskeleton staining images in Fig.5(C)of the original manuscript overlap,as shown in the white dotted box below.Given this error,we re-supplement the relevant experiments and take new images,as shown in the following Fig.5(C)of the new manuscript.The new cytoskeleton staining image has been added to the new manuscript.展开更多
The resection of malignant osteosarcoma often results in large segmental bone defects,and the residual cells can facilitate recurrence.Consequently,the treatment of osteosarcoma is a major challenge in clinical practi...The resection of malignant osteosarcoma often results in large segmental bone defects,and the residual cells can facilitate recurrence.Consequently,the treatment of osteosarcoma is a major challenge in clinical practice.The ideal goal of treatment for osteosarcoma is to eliminate it thoroughly,and repair the resultant bone defects as well as avoid bacterial infections.Herein,we fabricated a selenium/strontium/zinc-doped hydroxyapatite(Se/Sr/Zn-HA)powder by hydrothermal method,and then employed it with polycaprolactone(PCL)as ink to construct composite scaffolds through 3D printing,and finally introduced them in bone defect repair induced by malignant osteosarcoma.The resultant composite scaffolds integrated multiple functions involving anti-tumor,osteogenic,and antibacterial potentials,mainly attributed to the anti-tumor effects of SeO_(3)^(2-),osteogenic ef-fects of Sr^(2+)and Zn^(2+),and antibacterial effects of SeO_(3)^(2-)and Zn^(2+).In vitro studies confirmed that Se/Sr/Zn-HA leaching solution could induce apoptosis of osteosarcoma cells,differentiation of MSCs,and proliferation of MC3T3-E1 while showing excellent antibacterial properties.In vivo tests demonstrated that Se/Sr/Zn-HA could significantly suppress tumors after 8 days of injection,and the Se/Sr/Zn-HA-PCLs scaffold repaired femoral defects effectively after 3 months of implantation.Summarily,the Se/Sr/Zn-HA-PCLs composite scaffolds developed in this study were effective for tumor treatment,bone defect repair,and post-operative anti-infection,which provided a great potential to be a facile therapeutic material for osteosarcoma resection.展开更多
The authors regret<insert corrigendum text>.The cytoskeleton staining images in Fig.5(C)of the original manu-script overlap,as shown in the white dotted box below.Given this error,we re-supplement the relevant e...The authors regret<insert corrigendum text>.The cytoskeleton staining images in Fig.5(C)of the original manu-script overlap,as shown in the white dotted box below.Given this error,we re-supplement the relevant experiments and take new images,as shown in the following Fig.5(C)of the new manuscript.The new cytoskeleton staining image has been added to the new manuscript.展开更多
文摘The authors regret<insert corrigendum text>.The cytoskeleton staining images in Fig.5(C)of the original manuscript overlap,as shown in the white dotted box below.Given this error,we re-supplement the relevant experiments and take new images,as shown in the following Fig.5(C)of the new manuscript.The new cytoskeleton staining image has been added to the new manuscript.
基金supported by the National Natural Science Foundation of China(52071277,21802009)Jiangsu Provincial Key Research and Development Program(CN)(BE2019608)+4 种基金China Postdoctoral Science Foundation(2022M721685)Jiangsu Health Commission Medical Research Program(2020158)National Facility for Translational Med-icine(Shanghai)Open Program(TMSK-2021-304)2020 Nanjing In-ternational Science and Technology Cooperation ProgramNanjing Medical Science and Technology Development Key Program(ZKX18041).
文摘The resection of malignant osteosarcoma often results in large segmental bone defects,and the residual cells can facilitate recurrence.Consequently,the treatment of osteosarcoma is a major challenge in clinical practice.The ideal goal of treatment for osteosarcoma is to eliminate it thoroughly,and repair the resultant bone defects as well as avoid bacterial infections.Herein,we fabricated a selenium/strontium/zinc-doped hydroxyapatite(Se/Sr/Zn-HA)powder by hydrothermal method,and then employed it with polycaprolactone(PCL)as ink to construct composite scaffolds through 3D printing,and finally introduced them in bone defect repair induced by malignant osteosarcoma.The resultant composite scaffolds integrated multiple functions involving anti-tumor,osteogenic,and antibacterial potentials,mainly attributed to the anti-tumor effects of SeO_(3)^(2-),osteogenic ef-fects of Sr^(2+)and Zn^(2+),and antibacterial effects of SeO_(3)^(2-)and Zn^(2+).In vitro studies confirmed that Se/Sr/Zn-HA leaching solution could induce apoptosis of osteosarcoma cells,differentiation of MSCs,and proliferation of MC3T3-E1 while showing excellent antibacterial properties.In vivo tests demonstrated that Se/Sr/Zn-HA could significantly suppress tumors after 8 days of injection,and the Se/Sr/Zn-HA-PCLs scaffold repaired femoral defects effectively after 3 months of implantation.Summarily,the Se/Sr/Zn-HA-PCLs composite scaffolds developed in this study were effective for tumor treatment,bone defect repair,and post-operative anti-infection,which provided a great potential to be a facile therapeutic material for osteosarcoma resection.
文摘The authors regret<insert corrigendum text>.The cytoskeleton staining images in Fig.5(C)of the original manu-script overlap,as shown in the white dotted box below.Given this error,we re-supplement the relevant experiments and take new images,as shown in the following Fig.5(C)of the new manuscript.The new cytoskeleton staining image has been added to the new manuscript.
