Metal-catalyzed alkene arylalkoxylation is a powerful complexity-building strategy for the synthesis of oxygen heterocycles from simpleγ-unsaturated alcohols,but only a few examples of catalytic enantioselective meth...Metal-catalyzed alkene arylalkoxylation is a powerful complexity-building strategy for the synthesis of oxygen heterocycles from simpleγ-unsaturated alcohols,but only a few examples of catalytic enantioselective methods exist.Herein,an efficient palladium-catalyzed enantioselective arylalkoxylation ofγ-hydroxyalkenes with aryl halides is reported.The salient features of this transformation include a remarkable broad substrate scope,mild reaction conditions,and good functional group tolerance,delivering a series of chiral tetrahydrofurans containing a tertiary or quaternary stereocenter in good yields with up to 95%ee.The Xu10 ligand with a suitable side-arm was responsible for the high reactivity and good enantioselectivity of this transformation.展开更多
基金funding support of the National Natural Science Foundation of China(NSFC,Nos.22071060 and 22031004)the National Key R&D Program of China(No.2021YFF0701600)Shanghai Municipal Education Commission(No.20212308)。
文摘Metal-catalyzed alkene arylalkoxylation is a powerful complexity-building strategy for the synthesis of oxygen heterocycles from simpleγ-unsaturated alcohols,but only a few examples of catalytic enantioselective methods exist.Herein,an efficient palladium-catalyzed enantioselective arylalkoxylation ofγ-hydroxyalkenes with aryl halides is reported.The salient features of this transformation include a remarkable broad substrate scope,mild reaction conditions,and good functional group tolerance,delivering a series of chiral tetrahydrofurans containing a tertiary or quaternary stereocenter in good yields with up to 95%ee.The Xu10 ligand with a suitable side-arm was responsible for the high reactivity and good enantioselectivity of this transformation.
