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罹患新生期感染的极低出生体重婴儿的神经发育和生长缺陷 被引量:2
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作者 Stoll B.J. hansen n.i. +1 位作者 Adams-Chapman I. 郭俊 《世界核心医学期刊文摘(神经病学分册)》 2005年第4期5-5,共1页
Context: Neonatal infections are frequent complications of extremely low- birth- weight (ELBW) infants receiving intensive care. Objective: To determine if neonatal infections in ELBW infants are associated with incre... Context: Neonatal infections are frequent complications of extremely low- birth- weight (ELBW) infants receiving intensive care. Objective: To determine if neonatal infections in ELBW infants are associated with increased risks of adverse neurodevelopmental and growth sequelae in early childhood. Design, Setting, and Participants: Infants weighing 401 to 1000 g at birth (born in 1993- 2001) were enrolled in a prospectively collected very low- birth- weight registry at academic medical centers participating in the National Institute of Child Health and Human Development Neonatal Research Network. Neurodevelopmental and growth outcomes were assessed at a comprehensive follow- up visit at 18 to 22 months of corrected gestational age and compared by infection group. Eighty percent of survivors completed the follow- up visit and 6093 infants were studied. Registry data were used to classify infants by type of infection: uninfected (n=2161), clinical infection alone (n=1538), sepsis (n=1922), sepsis and necrotizing enterocolitis (n=279), or meningitis with or without sepsis (n=193). Main Outcome Measures: Cognitive and neuromotor development, neurologic status, vision and hearing, and growth (weight, length, and head circumference) were assessed at follow- up. Results: The majority of ELBW survivors (65% ) had at least 1 infection during their hospitalization after birth. Compared with uninfected infants, those in each of the 4 infection groups were significantly more likely to have adverse neurodevelopmental outcomes at follow- up, including cerebral palsy (range of significant odds ratios [ORs], 1.4- 1.7), low Bayley Scales of Infant Development II scores on the mental development index (ORs, 1.3- 1.6)- and psychomotor development index (ORs, 1.5- 2.4), and vision impairment (ORs, 1.3- 2.2). Infection in the neonatal period was also associated with impaired head growth, a known predictor of poor neurodevelopmental outcome. Conclusions: This large cohort study suggests that neonatal infections among ELBW infants are associated with poor neurodevelopmental and growth outcomes in early childhood. Additional studies are needed to elucidate the pathogenesis of brain injury in infants with infection so that novel interventions to improve these outcomes can be explored. 展开更多
关键词 低出生体重婴儿 神经发育 生长发育迟缓 发育指数 脑损伤 出生后 神经运动 脓毒症 头围 学龄前期
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研究超低出生体重儿患新生儿感染后神经和机体发育障碍情况
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作者 Stoll B.J. hansen n.i. +1 位作者 Adams-Chapman I. 李开 《世界核心医学期刊文摘(儿科学分册)》 2005年第4期5-6,共2页
研究背景:接受重症监护的超低出生体重儿(ELBW)多并发新生儿感染。目的:确定ELBW新生儿感染后。
关键词 新生儿感染 超低出生体重儿 机体发育 NEONATAL 发育不良 重症监护 智力发育指数 出生后 脑损伤 脓毒症
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