In this paper,some typical methods to promote mixing in supersonic combustion are reviewed,and the fluid-dynamic mechanism underpinning the development of the supersonic shear layer in the presence of a streamwise vor...In this paper,some typical methods to promote mixing in supersonic combustion are reviewed,and the fluid-dynamic mechanism underpinning the development of the supersonic shear layer in the presence of a streamwise vortex is analyzed through computational fluid dynamics.It is proven that the streamwise vortex-couple method is an excellent approach to enhance mixing.A specific combustor design is proposed accordingly.展开更多
The aim of this study was to investigate the extraction process and antioxidant activity of polyphenols from Yunnan Mengzi pomegranate peel.Single factor and orthogonal test were used as optimize the extract rate(ER)o...The aim of this study was to investigate the extraction process and antioxidant activity of polyphenols from Yunnan Mengzi pomegranate peel.Single factor and orthogonal test were used as optimize the extract rate(ER)of polyphenols from pomegranate peel(PGP).The polyphenols antioxidant activity was evaluated by DPPH·,·OH and total reducing ability,and compared with that of Vc.The optimum extraction conditions of polyphenols were as follows:ethanol concentration of 50%,liquid-solid ratio of 50:1,extraction temperature of 90°C,extraction for 4 h.Under these conditions,the ER of polyphenols from GPG was 8.15%.The results showed that the scavenging effects of polyphenols and Vc on DPPH·,·OH increased with increasing concentration,and the scavenging effect of polyphenols on DPPH·was higher than Vc in rang of 0.1-1.6µg/mL.When the concentration is greater than 0.6µg/mL,the scavenging effects of plyphenols on·OH is higher than Vc.The total reducing ability of polyphenols from PGP improved with the increase of concentration,and when the concentration was 8µg/mL,the total reducing ability was 114 U/mL.展开更多
The present paper proposes a Lagrangian criterion of unsteady flow separation for two-dimensional periodic flows based on the principle of weighted averaging zero skin-friction given by Haller (HALLER, G. Exact theor...The present paper proposes a Lagrangian criterion of unsteady flow separation for two-dimensional periodic flows based on the principle of weighted averaging zero skin-friction given by Haller (HALLER, G. Exact theory of unsteady separation for two-dimensional flows. Journal of Fluid Mechanics, 512, 257-311 (2004)). By analyzing the distribution of the finite-time Lyapunov exponent (FTLE) along the no-slip wall, it can be found that the periodic separation takes place at the point of the zero FTLE. This new criterion is verified with an analytical solution of the separation bubble and a numerical simulation of lid-driven cavity flows.展开更多
A gas-kinetic numerical method for directly solving the mesoscopic velocity distribution function equation is presented and applied to the study of three-dimensional complex flows and micro-channel flows covering vari...A gas-kinetic numerical method for directly solving the mesoscopic velocity distribution function equation is presented and applied to the study of three-dimensional complex flows and micro-channel flows covering various flow regimes. The unified velocity distribution function equation describing gas transport phenomena from rarefied transition to continuum flow regimes can be presented on the basis of the kinetic Boltzmann-Shakhov model equation. The gas-kinetic finite-difference schemes for the velocity distribution function are constructed by developing a discrete velocity ordinate method of gas kinetic theory and an unsteady time-splitting technique from computational fluid dynamics. Gas-kinetic boundary conditions and numerical modeling can be established by directly manipulating on the mesoscopic velocity distribution function. A new Gauss-type discrete velocity numerical integra- tion method can be developed and adopted to attack complex flows with different Mach numbers. HPF paral- lel strategy suitable for the gas-kinetic numerical method is investigated and adopted to solve three-dimensional complex problems. High Mach number flows around three-dimensional bodies are computed preliminarilywith massive scale parallel. It is noteworthy and of practical importance that the HPF parallel algorithm for solving three-dimensional complex problems can be effectively developed to cover various flow regimes. On the other hand, the gas-kinetic numerical method is extended and used to study micro-channel gas flows including the classical Couette flow, the Poiseuillechannel flow and pressure-driven gas flows in twodimensional short micro-channels. The numerical experience shows that the gas-kinetic algorithm may be a powerful tool in the numerical simulation of microscale gas flows occuring in the Micro-Electro-Mechanical System (MEMS).展开更多
In this paper, a fully third-order accurate projection method for solving the incompressible Navier-Stokes equations is proposed. To construct the scheme, a continuous projection procedure is firstly presented. We the...In this paper, a fully third-order accurate projection method for solving the incompressible Navier-Stokes equations is proposed. To construct the scheme, a continuous projection procedure is firstly presented. We then derive a sufficient condition for the continuous projection equations to be temporally third-order accurate approximations of the original Navier-Stokes equations by means of the localtruncation-error-analysis technique. The continuous projection equations are discretized temporally and spatially to third-order accuracy on the staggered grids, resulting in a fully third-order discrete projection scheme. The possibility to design higher-order projection methods is thus demonstrated in the present paper. A heuristic stability analysis is performed on this projection method showing the probability of its being stable. The stability of the present scheme is further verified through numerical tests. The third-order accuracy of the present projection method is validated by several numerical test cases.展开更多
The highly conserved target of rapamycin(TOR)pathway plays an important role in aging across species.Previous studies have established that inhibition of the TOR complex 1(TORC1)significantly extends lifespan in Caeno...The highly conserved target of rapamycin(TOR)pathway plays an important role in aging across species.Previous studies have established that inhibition of the TOR complex 1(TORC1)significantly extends lifespan in Caenorhabditis elegans.However,it has not been clear whether TORC1 perturbation affects aging in a spatiotemporal manner.Here,we apply the auxin-inducible degradation tool to knock down endogenous DAF-15,the C.elegans ortholog of regulatory associated protein of TOR(Raptor),to characterize its roles in aging.Global or tissue-specific inhibition of DAF-15 during development results in various growth defects,whereas neuron-specific knockdown of DAF-15 during adulthood significantly extends lifespan and healthspan.The neuronal DAF-15 deficiency-induced longevity requires the intestinal activities of DAF-16/FOXO and PHA-4/FOXA transcription factors,as well as the AAK-2/AMP-activated protein kinaseαcatalytic subunit.Transcriptome profiling reveals that the neuronal DAF-15 knockdown promotes the expression of genes involved in protection.These findings define the tissue-specific roles of TORC1 in healthy aging and highlight the importance of neuronal modulation of aging.展开更多
The purpose of this article is to summarize our recent progress in high-order and high accurate CFD methods for flow problems with complex grids as well as to discuss the engineering prospects in using these methods.D...The purpose of this article is to summarize our recent progress in high-order and high accurate CFD methods for flow problems with complex grids as well as to discuss the engineering prospects in using these methods.Despite the rapid development of high-order algorithms in CFD,the applications of high-order and high accurate methods on complex configurations are still limited.One of the main reasons which hinder the widely applications of thesemethods is the complexity of grids.Many aspects which can be neglected for low-order schemes must be treated carefully for high-order ones when the configurations are complex.In order to implement highorder finite difference schemes on complex multi-block grids,the geometric conservation lawand block-interface conditions are discussed.A conservativemetricmethod is applied to calculate the grid derivatives,and a characteristic-based interface condition is employed to fulfil high-order multi-block computing.The fifth-order WCNS-E-5 proposed by Deng[9,10]is applied to simulate flows with complex grids,including a double-delta wing,a transonic airplane configuration,and a hypersonic X-38 configuration.The results in this paper and the references show pleasant prospects in engineering-oriented applications of high-order schemes.展开更多
In this paper,a divergence-free and pressure-oscillation-free projection method for solving the incompressible Navier-Stokes equations on the non-staggered grid is presented.The exact discrete projection method is use...In this paper,a divergence-free and pressure-oscillation-free projection method for solving the incompressible Navier-Stokes equations on the non-staggered grid is presented.The exact discrete projection method is used to compute the velocity field,which ensures the discrete divergence of the velocity field is zero.In order to eliminate the odd-even decoupling in the pressure field,a filtering procedure is proposed and applied to the pressure field.We have shown this filter recovers the grid scale ellipticity in the pressure field and the odd-even decoupling can be removed effectively.The proposed numerical scheme is further verified through numerical experiments.展开更多
Analyses were performed on the dispersion overshoot and inverse dissipation of the high-order finite difference scheme using Fourier and precision analysis.Schemes under discussion included the pointwise-and staggered...Analyses were performed on the dispersion overshoot and inverse dissipation of the high-order finite difference scheme using Fourier and precision analysis.Schemes under discussion included the pointwise-and staggered-grid type,and were presented in weighted form using candidate schemes with third-order accuracy and three-point stencil.All of these were commonly used in the construction of difference schemes.Criteria for the dispersion overshoot were presented and their critical states were discussed.Two kinds of instabilities were studied due to inverse dissipation,especially those that occur at lower wave numbers.Criteria for the occurrence were presented and the relationship of the two instabilities was discussed.Comparisons were made between the analytical results and the dispersion/dissipation relations by Fourier transformation of typical schemes.As an example,an application of the criteria was given for the remedy of inverse dissipation in Weirs&Mart´ın’s third-order scheme.展开更多
基金supported by the National Natural Science Foundation of China(No.12002193)the Shandong Provincial Natural Science Foundation,China(No.ZR2019QA018).
文摘In this paper,some typical methods to promote mixing in supersonic combustion are reviewed,and the fluid-dynamic mechanism underpinning the development of the supersonic shear layer in the presence of a streamwise vortex is analyzed through computational fluid dynamics.It is proven that the streamwise vortex-couple method is an excellent approach to enhance mixing.A specific combustor design is proposed accordingly.
基金This project is funded by Livelihood Plan Project of Department of Science and Technology of Liaoning Province(2021JH2/10300069,2019-ZD-0845)Department of Education of Liaoning Province(LJKZ0918)Shenyang Pharmaceutical University Scientific Research Foundation(GGJJ2015102).
文摘The aim of this study was to investigate the extraction process and antioxidant activity of polyphenols from Yunnan Mengzi pomegranate peel.Single factor and orthogonal test were used as optimize the extract rate(ER)of polyphenols from pomegranate peel(PGP).The polyphenols antioxidant activity was evaluated by DPPH·,·OH and total reducing ability,and compared with that of Vc.The optimum extraction conditions of polyphenols were as follows:ethanol concentration of 50%,liquid-solid ratio of 50:1,extraction temperature of 90°C,extraction for 4 h.Under these conditions,the ER of polyphenols from GPG was 8.15%.The results showed that the scavenging effects of polyphenols and Vc on DPPH·,·OH increased with increasing concentration,and the scavenging effect of polyphenols on DPPH·was higher than Vc in rang of 0.1-1.6µg/mL.When the concentration is greater than 0.6µg/mL,the scavenging effects of plyphenols on·OH is higher than Vc.The total reducing ability of polyphenols from PGP improved with the increase of concentration,and when the concentration was 8µg/mL,the total reducing ability was 114 U/mL.
基金supported by the National Natural Science Foundation of China(Nos.11372340 and 11732016)
文摘The present paper proposes a Lagrangian criterion of unsteady flow separation for two-dimensional periodic flows based on the principle of weighted averaging zero skin-friction given by Haller (HALLER, G. Exact theory of unsteady separation for two-dimensional flows. Journal of Fluid Mechanics, 512, 257-311 (2004)). By analyzing the distribution of the finite-time Lyapunov exponent (FTLE) along the no-slip wall, it can be found that the periodic separation takes place at the point of the zero FTLE. This new criterion is verified with an analytical solution of the separation bubble and a numerical simulation of lid-driven cavity flows.
基金the National Natural Science Foundation of China(90205009 and 10321002)the National Parallel Computing Center in Beijing.
文摘A gas-kinetic numerical method for directly solving the mesoscopic velocity distribution function equation is presented and applied to the study of three-dimensional complex flows and micro-channel flows covering various flow regimes. The unified velocity distribution function equation describing gas transport phenomena from rarefied transition to continuum flow regimes can be presented on the basis of the kinetic Boltzmann-Shakhov model equation. The gas-kinetic finite-difference schemes for the velocity distribution function are constructed by developing a discrete velocity ordinate method of gas kinetic theory and an unsteady time-splitting technique from computational fluid dynamics. Gas-kinetic boundary conditions and numerical modeling can be established by directly manipulating on the mesoscopic velocity distribution function. A new Gauss-type discrete velocity numerical integra- tion method can be developed and adopted to attack complex flows with different Mach numbers. HPF paral- lel strategy suitable for the gas-kinetic numerical method is investigated and adopted to solve three-dimensional complex problems. High Mach number flows around three-dimensional bodies are computed preliminarilywith massive scale parallel. It is noteworthy and of practical importance that the HPF parallel algorithm for solving three-dimensional complex problems can be effectively developed to cover various flow regimes. On the other hand, the gas-kinetic numerical method is extended and used to study micro-channel gas flows including the classical Couette flow, the Poiseuillechannel flow and pressure-driven gas flows in twodimensional short micro-channels. The numerical experience shows that the gas-kinetic algorithm may be a powerful tool in the numerical simulation of microscale gas flows occuring in the Micro-Electro-Mechanical System (MEMS).
基金The project supported by the China NKBRSF(2001CB409604)
文摘In this paper, a fully third-order accurate projection method for solving the incompressible Navier-Stokes equations is proposed. To construct the scheme, a continuous projection procedure is firstly presented. We then derive a sufficient condition for the continuous projection equations to be temporally third-order accurate approximations of the original Navier-Stokes equations by means of the localtruncation-error-analysis technique. The continuous projection equations are discretized temporally and spatially to third-order accuracy on the staggered grids, resulting in a fully third-order discrete projection scheme. The possibility to design higher-order projection methods is thus demonstrated in the present paper. A heuristic stability analysis is performed on this projection method showing the probability of its being stable. The stability of the present scheme is further verified through numerical tests. The third-order accuracy of the present projection method is validated by several numerical test cases.
基金the National Key R&D Program of China(2021YFA0805802 to D.C.)the National Natural Science Foundation of China(31971092 and 32171156 to D.C.)Some strains were provided by the Caenorhabditis Genetics Center(CGC),which is funded by NIHOffice of Research Infrastructure Programs(P40 OD010440).
文摘The highly conserved target of rapamycin(TOR)pathway plays an important role in aging across species.Previous studies have established that inhibition of the TOR complex 1(TORC1)significantly extends lifespan in Caenorhabditis elegans.However,it has not been clear whether TORC1 perturbation affects aging in a spatiotemporal manner.Here,we apply the auxin-inducible degradation tool to knock down endogenous DAF-15,the C.elegans ortholog of regulatory associated protein of TOR(Raptor),to characterize its roles in aging.Global or tissue-specific inhibition of DAF-15 during development results in various growth defects,whereas neuron-specific knockdown of DAF-15 during adulthood significantly extends lifespan and healthspan.The neuronal DAF-15 deficiency-induced longevity requires the intestinal activities of DAF-16/FOXO and PHA-4/FOXA transcription factors,as well as the AAK-2/AMP-activated protein kinaseαcatalytic subunit.Transcriptome profiling reveals that the neuronal DAF-15 knockdown promotes the expression of genes involved in protection.These findings define the tissue-specific roles of TORC1 in healthy aging and highlight the importance of neuronal modulation of aging.
基金This studywas supported by the project of National Natural Science Foundation of China(Grant 11072259 and 10621062)National Basic Research Program of China(Grant No.2009CB723800).The authors would like to thank Dr.Huayong Liu,and Assistant Researcher GuangxueWang of State Key Laboratory of Aerodynamics for their contributions.
文摘The purpose of this article is to summarize our recent progress in high-order and high accurate CFD methods for flow problems with complex grids as well as to discuss the engineering prospects in using these methods.Despite the rapid development of high-order algorithms in CFD,the applications of high-order and high accurate methods on complex configurations are still limited.One of the main reasons which hinder the widely applications of thesemethods is the complexity of grids.Many aspects which can be neglected for low-order schemes must be treated carefully for high-order ones when the configurations are complex.In order to implement highorder finite difference schemes on complex multi-block grids,the geometric conservation lawand block-interface conditions are discussed.A conservativemetricmethod is applied to calculate the grid derivatives,and a characteristic-based interface condition is employed to fulfil high-order multi-block computing.The fifth-order WCNS-E-5 proposed by Deng[9,10]is applied to simulate flows with complex grids,including a double-delta wing,a transonic airplane configuration,and a hypersonic X-38 configuration.The results in this paper and the references show pleasant prospects in engineering-oriented applications of high-order schemes.
文摘In this paper,a divergence-free and pressure-oscillation-free projection method for solving the incompressible Navier-Stokes equations on the non-staggered grid is presented.The exact discrete projection method is used to compute the velocity field,which ensures the discrete divergence of the velocity field is zero.In order to eliminate the odd-even decoupling in the pressure field,a filtering procedure is proposed and applied to the pressure field.We have shown this filter recovers the grid scale ellipticity in the pressure field and the odd-even decoupling can be removed effectively.The proposed numerical scheme is further verified through numerical experiments.
基金This work was sponsored by the National Science Foundation of China under Grant number 10972023 and 11272037also partially supported by National Basic Research Program of China(No.2009CB724100).The first author was very grateful to Prof.Frank Lu for his efforts on the revision of the manuscript.
文摘Analyses were performed on the dispersion overshoot and inverse dissipation of the high-order finite difference scheme using Fourier and precision analysis.Schemes under discussion included the pointwise-and staggered-grid type,and were presented in weighted form using candidate schemes with third-order accuracy and three-point stencil.All of these were commonly used in the construction of difference schemes.Criteria for the dispersion overshoot were presented and their critical states were discussed.Two kinds of instabilities were studied due to inverse dissipation,especially those that occur at lower wave numbers.Criteria for the occurrence were presented and the relationship of the two instabilities was discussed.Comparisons were made between the analytical results and the dispersion/dissipation relations by Fourier transformation of typical schemes.As an example,an application of the criteria was given for the remedy of inverse dissipation in Weirs&Mart´ın’s third-order scheme.