The Number of Five Basic Elements' Motion of Traditional Chinese Medicine and Cancer Prediction

"The number of five basic elements'motion"varies according to the date of birth,which is tightly tied to human health.To predict cancer with"the number of five basic elements'motion"is simple,accurate,worth of research and popularizing.The theory of“five basic elements'motion and six climatic changes”is a key part of Traditional Chinese Medicine,“the number of five basic elements'motion”is strongly related to the physiology and pathology of human body.Combine with folk pathology prediction,“the number of five basic elements'motion”has been proved to have some scientific validity and of high accuracy in cancer prediction,it is worth to study,research and be discussed in-depth.

Signaling pathways and targeted therapies for psoriasis

Psoriasis is a common,chronic,and inflammatory skin disease with a high burden on individuals,health systems,and society worldwide.With the immunological pathologies and pathogenesis of psoriasis becoming gradually revealed,the therapeutic approaches for this disease have gained revolutionary progress.Nevertheless,the mechanisms of less common forms of psoriasis remain elusive.Furthermore,severe adverse effects and the recurrence of disease upon treatment cessation should be noted and addressed during the treatment,which,however,has been rarely explored with the integration of preliminary findings.Therefore,it is crucial to have a comprehensive understanding of the mechanisms behind psoriasis pathogenesis,which might offer new insights for research and lead to more substantive progress in therapeutic approaches and expand clinical options for psoriasis treatment.In this review,we looked to briefly introduce the epidemiology,clinical subtypes,pathophysiology,and comorbidities of psoriasis and systematically discuss the signaling pathways involving extracellular cytokines and intracellular transmission,as well as the cross-talk between them.In the discussion,we also paid more attention to the potential metabolic and epigenetic mechanisms of psoriasis and the molecular mechanistic cascades related to its comorbidities.This review also outlined current treatment for psoriasis,especially targeted therapies and novel therapeutic strategies,as well as the potential mechanism of disease recurrence.

Design of PANDA ring-core fiber with 10 polarization-maintaining modes

We present a polarization-maintaining PANDA ring-core fiber(PM-PRCF) characterized by the combination of a ring-core structure with two stress-applying rods. This special fiber design separates the adjacent modes and avoids the cutoff of the higher-order modes, which is a common problem in elliptical core polarization-maintaining few-mode fibers. Using a high-contrast index ring and stress-induced birefringence, the PM-PRCF features support for 10 vector modes, with effective refractive index separations from their adjacent modes >10^(-4).Broadband performance is investigated subsequently over a wide wavelength range from 1500 to 1630 nm.The proposed fiber is targeted at applications in space-division multiplexing while eliminating the complex multiple-input multiple-output signal processing.

Researches in microwave photonics based packages for millimeter wave system with wide bandwidth and large dynamic range

This paper presents an introduction to the researches in microwave photonics based packages and its application, a 973 project （No. 2012CB315600）, which focuses on addressing new requirements for millimeter wave （MMW） system to work with higher frequency, wider bandwidth, larger dynamic range and longer distance of signal distribution. Its key scientific problems, main research contents and objectives are briefed, and some latest achievements by the project team, including generation of linear frequency modulation wave （LFMW）, tunable optoelectronic oscillator （OEO） with lower phase noise, reconfigurable filter with higher Q value, time delay line with wider frequency range, down conversion with gain, and local oscillator （LO） transmission with stable phase, are introduced briefly.