The micro-impulse generated by ablating an aluminum target in double-pulse laser bursts with different interpulse delays was investigated using a torsion pendulum.The plasma plume was simultaneously visualized using h...The micro-impulse generated by ablating an aluminum target in double-pulse laser bursts with different interpulse delays was investigated using a torsion pendulum.The plasma plume was simultaneously visualized using high-speed photography to analyze the coupling mechanism of the ablation impulse.The experiment was carried out using a pulsed laser with a pulse width of 8 ns and a wavelength of 1064 nm.The experimental results show that an impulse with an interpulse delay of 60 ns is roughly 60%higher than that with no delay between the two pulses,when the energy of both laser pulses is 50 m J.Therefore,double-pulse schemes could enhance the ablation impulse under certain conditions.This is because the ablation of the first laser pulse changes the optical properties of the aluminum target surface,increasing the absorptivity.However,the ablation impulse is reduced with a time delay of 20 ns when the energy of both laser pulses is100 mJ or 150 mJ.It can be concluded that the plasma produced by ablating the aluminum with the first pulse shields the second laser pulse.To summarize,the experimental results show that different delay times in a double-pulse scheme have a significant effect on the ablation impulse.The study provides a reference for the optimization of the parameters when laser ablation propulsion with a double-pulse scheme is applied in the fields of space debris removal,laser ablation thrusters,and so on.展开更多
We developed an automatic seismic wave and phase detection software based on PhaseNet,an efficient and highly generalized deep learning neural network for P-and S-wave phase picking.The software organically combines m...We developed an automatic seismic wave and phase detection software based on PhaseNet,an efficient and highly generalized deep learning neural network for P-and S-wave phase picking.The software organically combines multiple modules including application terminal interface,docker container,data visualization,SSH protocol data transmission and other auxiliary modules.Characterized by a series of technologically powerful functions,the software is highly convenient for all users.To obtain the P-and S-wave picks,one only needs to prepare threecomponent seismic data as input and customize some parameters in the interface.In particular,the software can automatically identify complex waveforms(i.e.continuous or truncated waves)and support multiple types of input data such as SAC,MSEED,NumPy array,etc.A test on the dataset of the Wenchuan aftershocks shows the generalization ability and detection accuracy of the software.The software is expected to increase the efficiency and subjectivity in the manual processing of large amounts of seismic data,thereby providing convenience to regional network monitoring staffs and researchers in the study of Earth's interior.展开更多
This paper studies a defined contribution(DC)pension fund investment problem with return of premiums clauses in a stochastic interest rate and stochastic volatility environment.In practice,most of pension plans were s...This paper studies a defined contribution(DC)pension fund investment problem with return of premiums clauses in a stochastic interest rate and stochastic volatility environment.In practice,most of pension plans were subject to the return of premiums clauses to protect the rights of pension members who died before retirement.In the mathematical modeling,we assume that a part of pension members could withdraw their premiums if they died before retirement and surviving members could equally share the difference between accumulated contributions and returned premiums.We suppose that the financial market consists of a risk-free asset,a stock,and a zero-coupon bond.The interest rate is driven by a stochastic affine interest rate model and the stock price follows the Heston’s stochastic volatility model with stochastic interest rates.Different fund managers have different risk preferences,and the hyperbolic absolute risk aversion(HARA)utility function is a general one including a power utility,an exponential utility,and a logarithm utility as special cases.We are concerned with an optimal portfolio to maximize the expected utility of terminal wealth by choosing the HARA utility function in the analysis.By using the principle of dynamic programming and Legendre transform-dual theory,we obtain explicit solutions of optimal strategies.Some special cases are also derived in detail.Finally,a numerical simulation is provided to illustrate our results.展开更多
The circumferentially averaged equation of the inlet flow radial equilibrium in axial compressor was deduced. It indicates that the blade inlet radial pressure gradient is closely related to the radial component of th...The circumferentially averaged equation of the inlet flow radial equilibrium in axial compressor was deduced. It indicates that the blade inlet radial pressure gradient is closely related to the radial component of the circumferential fluctuation(CF) source item. Several simplified cascades with/without aerodynamic loading were numerically studied to investigate the effects of blade bowing on the inlet flow radial equilibrium. A data reduction program was conducted to obtain the CF source from three-dimensional(3D) simulation results. Flow parameters at the passage inlet were focused on and each term in the radial equilibrium equation was discussed quantitatively. Results indicate that the inviscid blade force is the inducement of the inlet CF due to geometrical asymmetry. Blade bowing induces variation of the inlet CF, thus changes the radial pressure gradient and leads to flow migration before leading edge(LE) in the cascades. Positive bowing drives the inlet flow to migrate from end walls to mid-span and negative bowing turns it to the reverse direction to build a new equilibrium. In addition, comparative studies indicate that the inlet Mach number and blade loading can efficiently impact the effectiveness of blade bowing on radial equilibrium in compressor design.展开更多
The resolution of single molecule localization imaging techniques largely depends on the precision of localization algorithms.However,the commonly used Gaussian function is not appropriate for anisotropic dipoles beca...The resolution of single molecule localization imaging techniques largely depends on the precision of localization algorithms.However,the commonly used Gaussian function is not appropriate for anisotropic dipoles because it is not the true point spread function.We derived the theoretical point spread function of tilted dipoles with restricted mobility and developed an algorithm based on an artifi cial neural network for estimating the localization,orientation and mobility of individual dipoles.Compared with fi tting-based methods,our algorithm demonstrated ultrafast speed and higher accuracy,reduced sensitivity to defocusing,strong robustness and adaptability,making it an optimal choice for both two-dimensional and threedimensional super-resolution imaging analysis.展开更多
Let g = W1 be the Witt algebra over an algebraically closed field k of characteristic p 〉 3, and let ∮(g) = {(x,y) ∈ g×g [x,y] = 0} be the commuting variety of g. In contrast with the case of classical Lie...Let g = W1 be the Witt algebra over an algebraically closed field k of characteristic p 〉 3, and let ∮(g) = {(x,y) ∈ g×g [x,y] = 0} be the commuting variety of g. In contrast with the case of classical Lie algebras of P. Levy [J. Algebra, 2002, 250: 473-484], we show that the variety ∮(g) is reducible, and not equidimensional. Irreducible components of ∮(g) and their dimensions are precisely given. As a consequence, the variety ∮(g) is not normal.展开更多
String-pulling is one of the most widely used paradigms in an imal cog nition research. We in vestigated how azure-wi nged magpies Cyanopica cyan us solve multiple-string problems that they have never encountered befo...String-pulling is one of the most widely used paradigms in an imal cog nition research. We in vestigated how azure-wi nged magpies Cyanopica cyan us solve multiple-string problems that they have never encountered before. In Experiment 1, the strings were arranged in parallel, slanted, or crossed to investigate what rules azure-winged magpies use to solve multiple spatial relations of strings. Experiment 2 assessed whether the subjects understood the connection between the string and the bait while taking advantage of broken strings. In Experiment 3, the subjects were confronted with strings of different lengths attached to rewards in order to explore whether the string length, as a proxy for the pulling efficiency or reward distanee, was crucial for the birds' choice of which string to pull. Gen erally, the birds were successful in tasks where the reward was close to the correct string's end, and they relied on a "proximity rule" in most cases. The results showed that azure-winged magpies had a partial understanding of the physical principles underlying the string-pulling but were stumped by complex spatial relations. They likely relied on simple strategies such as the proximity rule to solve the tasks. The effects of in dividual difference and experiential learning on string-pulling performance are also discussed.展开更多
Dear Editor,Living systems such as Caenorhabditis elegans are organized by interaction networks of biopolymer and small mol-ecules.The molecular engineering of specifi c targets to monitor and control these biological...Dear Editor,Living systems such as Caenorhabditis elegans are organized by interaction networks of biopolymer and small mol-ecules.The molecular engineering of specifi c targets to monitor and control these biological molecules has led to significant advances in our understand-ing of how biological systems are organ-ized,maintain themselves and disin-tegrate(Prescher and Bertozzi,2005).For instance,green fl uorescent protein(GFP)derived from jellyfi sh Aequorea Victoria helps us to accurately locate and observe proteins over long term periods.In addition,many novel LOV(light,oxy-gen,or voltage)domains such as LOV2-Jαand Vivid offer the possibility of cell-based motility management and tissue-based gene expression control(Wu et al.,2009;Wang et al.,2012).展开更多
Lipid droplets, which are conserved across almost all species, are cytoplasmic organelles used to store neutral lipids. Identification of lipid droplet regulators will be conducive to resolving obesity and other fat-a...Lipid droplets, which are conserved across almost all species, are cytoplasmic organelles used to store neutral lipids. Identification of lipid droplet regulators will be conducive to resolving obesity and other fat-associated diseases. In this paper, we selected 11 candidates that might be associated with lipid metabolism in Caenorhabditis elegans . Using a BODIPY 493/503-based flow cytometry screen, 6 negative and 3 positive regulators of fat content were identified. We selected one negative regulator of lipid content, C13C4.5 , for future study. C13C4.5 was mainly expressed in the worm intestine. We found that this gene was important for maintaining the metabolism of lipid droplets. Biochemical results revealed that 50% of triacylglycerol (TAG) was lost in C13C4.5 knockout worms. Stimulated Raman scattering (SRS) signals in C13C4.5 mutants showed only 49.6% of the fat content in the proximal intestinal region and 86.3% in the distal intestinal region compared with wild type animals. The mean values of lipid droplet size and intensity in C13C4.5 knockout animals were found to be significantly decreased compared with those in wild type worms. The LMP-1-labeled membrane structures in worm intestines were also enlarged in C13C4.5 mutant animals. Finally, fertility defects were found in C13C4.5 ( ok2087 ) mutants. Taken together, these results indicate that C13C4.5 may regulate the fertility of C. elegans by changing the size and fat content of lipid droplets by interfering with lysosomal morphology and function.展开更多
This article reviews advanced process and electron device technology of integrated circuits,including recent featuring progress and potential solutions for future development.In 5 years,for pushing the performance of ...This article reviews advanced process and electron device technology of integrated circuits,including recent featuring progress and potential solutions for future development.In 5 years,for pushing the performance of fin field-effect transistors(FinFET)to its limitations,several processes and device boosters are provided.Then,the three-dimensional(3 D)integration schemes with alternative materials and device architectures will pave paths for future technology evolution.Finally,it could be concluded that Moore’s law will undoubtedly continue in the next 15 years.展开更多
This paper studies a dynamic mean-variance portfolio selection problem with random liability in the affine interest rate environment, where the financial market consists of three assets: one risk-free asset, one risky...This paper studies a dynamic mean-variance portfolio selection problem with random liability in the affine interest rate environment, where the financial market consists of three assets: one risk-free asset, one risky asset and one zero-coupon bond. Assume that short rate is driven by affine interest rate model and liability process is described by the drifted Brownian motion, in addition, stock price dynamics is affected by interest rate dynamics. The investors expect to look for an optimal strategy to minimize the variance of the terminal surplus for a given expected terminal surplus. The efficient strategy and the efficient frontier are explicitly obtained by applying dynamic programming principle and Lagrange duality theorem. A numerical example is given to illustrate our results and some economic implications are analyzed.展开更多
Quantum dot microlasers,as multifunaional optical source components,are of great importance for full-color highpixel display,miniaturized coherent lighting,and on-chip integrated photonic and electronic circuits.Since...Quantum dot microlasers,as multifunaional optical source components,are of great importance for full-color highpixel display,miniaturized coherent lighting,and on-chip integrated photonic and electronic circuits.Since the first synthesis of colloidal quantum dots(CQD)in the 1990s,motivation to realize high-performance low-cost CQD micro-/nanolasers has been a driving force for more than three decades.However,the low packing density,inefficient coupling of CQDs with optical cavities,and the poor thermal stability of miniaturized complex systems make it challenging to achieve practical CQD microVnanolasers,especially to combine the continuous working ability at high temperatures and the low-cost potential with mass-produced synthesis technologies.Herein,we developed closepacked CQD-assembled microspheres and embedded them in a silica matrix through the rapid self-aggregation and solidification of CdSe/ZnS CQD.This technology addresses the core issues of photoluminescence(PL)quenching effect and low optical gain in traditional CQD laser research.High-efficiency low-threshold CQD microlasers are demonstrated together with long-playing(40 min)working stability even at 450 K under pulsed laser excitation,which is the highest operational temperature for CQD lasers.Moreover,single-mode CQD microlasers are obtained with tunable wavelengths across the entire visible spectral range.The chemosynthesis process supports the mass-produced potential of high-density integrated CQD microlasers,promoting CQD-based low-cost high-temperature microdevices.展开更多
基金supported by National Natural Science Foundation of China(Nos.11502301 and 11602304)。
文摘The micro-impulse generated by ablating an aluminum target in double-pulse laser bursts with different interpulse delays was investigated using a torsion pendulum.The plasma plume was simultaneously visualized using high-speed photography to analyze the coupling mechanism of the ablation impulse.The experiment was carried out using a pulsed laser with a pulse width of 8 ns and a wavelength of 1064 nm.The experimental results show that an impulse with an interpulse delay of 60 ns is roughly 60%higher than that with no delay between the two pulses,when the energy of both laser pulses is 50 m J.Therefore,double-pulse schemes could enhance the ablation impulse under certain conditions.This is because the ablation of the first laser pulse changes the optical properties of the aluminum target surface,increasing the absorptivity.However,the ablation impulse is reduced with a time delay of 20 ns when the energy of both laser pulses is100 mJ or 150 mJ.It can be concluded that the plasma produced by ablating the aluminum with the first pulse shields the second laser pulse.To summarize,the experimental results show that different delay times in a double-pulse scheme have a significant effect on the ablation impulse.The study provides a reference for the optimization of the parameters when laser ablation propulsion with a double-pulse scheme is applied in the fields of space debris removal,laser ablation thrusters,and so on.
基金This study is jointly sponsored by the Basic Scientific Research Fee of Institute of Geophysics,China Earthquake Administration(DQJB19A0114)the National Natural Science Foundation of China(41804047).
文摘We developed an automatic seismic wave and phase detection software based on PhaseNet,an efficient and highly generalized deep learning neural network for P-and S-wave phase picking.The software organically combines multiple modules including application terminal interface,docker container,data visualization,SSH protocol data transmission and other auxiliary modules.Characterized by a series of technologically powerful functions,the software is highly convenient for all users.To obtain the P-and S-wave picks,one only needs to prepare threecomponent seismic data as input and customize some parameters in the interface.In particular,the software can automatically identify complex waveforms(i.e.continuous or truncated waves)and support multiple types of input data such as SAC,MSEED,NumPy array,etc.A test on the dataset of the Wenchuan aftershocks shows the generalization ability and detection accuracy of the software.The software is expected to increase the efficiency and subjectivity in the manual processing of large amounts of seismic data,thereby providing convenience to regional network monitoring staffs and researchers in the study of Earth's interior.
基金supported by the National Social Science Foundation of China (No.21FJYB042)。
文摘This paper studies a defined contribution(DC)pension fund investment problem with return of premiums clauses in a stochastic interest rate and stochastic volatility environment.In practice,most of pension plans were subject to the return of premiums clauses to protect the rights of pension members who died before retirement.In the mathematical modeling,we assume that a part of pension members could withdraw their premiums if they died before retirement and surviving members could equally share the difference between accumulated contributions and returned premiums.We suppose that the financial market consists of a risk-free asset,a stock,and a zero-coupon bond.The interest rate is driven by a stochastic affine interest rate model and the stock price follows the Heston’s stochastic volatility model with stochastic interest rates.Different fund managers have different risk preferences,and the hyperbolic absolute risk aversion(HARA)utility function is a general one including a power utility,an exponential utility,and a logarithm utility as special cases.We are concerned with an optimal portfolio to maximize the expected utility of terminal wealth by choosing the HARA utility function in the analysis.By using the principle of dynamic programming and Legendre transform-dual theory,we obtain explicit solutions of optimal strategies.Some special cases are also derived in detail.Finally,a numerical simulation is provided to illustrate our results.
基金supported by the National Natural Science Foundation of China (Nos.51236001,51006005)the National Basic Research Program of China (No. 2012CB720201)Beijing Natural Science Foundation (No. 3151002)
文摘The circumferentially averaged equation of the inlet flow radial equilibrium in axial compressor was deduced. It indicates that the blade inlet radial pressure gradient is closely related to the radial component of the circumferential fluctuation(CF) source item. Several simplified cascades with/without aerodynamic loading were numerically studied to investigate the effects of blade bowing on the inlet flow radial equilibrium. A data reduction program was conducted to obtain the CF source from three-dimensional(3D) simulation results. Flow parameters at the passage inlet were focused on and each term in the radial equilibrium equation was discussed quantitatively. Results indicate that the inviscid blade force is the inducement of the inlet CF due to geometrical asymmetry. Blade bowing induces variation of the inlet CF, thus changes the radial pressure gradient and leads to flow migration before leading edge(LE) in the cascades. Positive bowing drives the inlet flow to migrate from end walls to mid-span and negative bowing turns it to the reverse direction to build a new equilibrium. In addition, comparative studies indicate that the inlet Mach number and blade loading can efficiently impact the effectiveness of blade bowing on radial equilibrium in compressor design.
基金We thank L.L.Looger(Janelia Farm Research Campus)for providing the mEos2 cDNA and Toshio Yanagida(Osaka University,Japan)for sharing the Q rods.This work was supported by grants from the National Basic Research Program(973 Program)(Nos.2010CB833701 and 2010CB912303)the National Key Technology R&D Program(SQ2011SF11B01041)+2 种基金the National Natural Science Foundation of China(Grant Nos.31130065,31170818,90913022,31127901,and 31100615)the Beijing Natural Science Foundation(7121008)the Chinese Academy of Sciences Project(KSCX1-1W-J-3,KSCX2-EWQ-11,and 2009-154-27).
文摘The resolution of single molecule localization imaging techniques largely depends on the precision of localization algorithms.However,the commonly used Gaussian function is not appropriate for anisotropic dipoles because it is not the true point spread function.We derived the theoretical point spread function of tilted dipoles with restricted mobility and developed an algorithm based on an artifi cial neural network for estimating the localization,orientation and mobility of individual dipoles.Compared with fi tting-based methods,our algorithm demonstrated ultrafast speed and higher accuracy,reduced sensitivity to defocusing,strong robustness and adaptability,making it an optimal choice for both two-dimensional and threedimensional super-resolution imaging analysis.
文摘Let g = W1 be the Witt algebra over an algebraically closed field k of characteristic p 〉 3, and let ∮(g) = {(x,y) ∈ g×g [x,y] = 0} be the commuting variety of g. In contrast with the case of classical Lie algebras of P. Levy [J. Algebra, 2002, 250: 473-484], we show that the variety ∮(g) is reducible, and not equidimensional. Irreducible components of ∮(g) and their dimensions are precisely given. As a consequence, the variety ∮(g) is not normal.
基金National Natural Science Foundation of China (no. 31772470, J1210026)Project of National Biodiversity Observation Network-Bird (2016-2018).
文摘String-pulling is one of the most widely used paradigms in an imal cog nition research. We in vestigated how azure-wi nged magpies Cyanopica cyan us solve multiple-string problems that they have never encountered before. In Experiment 1, the strings were arranged in parallel, slanted, or crossed to investigate what rules azure-winged magpies use to solve multiple spatial relations of strings. Experiment 2 assessed whether the subjects understood the connection between the string and the bait while taking advantage of broken strings. In Experiment 3, the subjects were confronted with strings of different lengths attached to rewards in order to explore whether the string length, as a proxy for the pulling efficiency or reward distanee, was crucial for the birds' choice of which string to pull. Gen erally, the birds were successful in tasks where the reward was close to the correct string's end, and they relied on a "proximity rule" in most cases. The results showed that azure-winged magpies had a partial understanding of the physical principles underlying the string-pulling but were stumped by complex spatial relations. They likely relied on simple strategies such as the proximity rule to solve the tasks. The effects of in dividual difference and experiential learning on string-pulling performance are also discussed.
基金This project was supported by the National Basic Research Program(973 Program)(Nos.2010CB912303 and 2010CB833701)the National Natural Science Foundation of China(Grant Nos.90913022 and 31170818)the project from Chinese Academy of Sciences(KSCX2-EW-Q-11).
文摘Dear Editor,Living systems such as Caenorhabditis elegans are organized by interaction networks of biopolymer and small mol-ecules.The molecular engineering of specifi c targets to monitor and control these biological molecules has led to significant advances in our understand-ing of how biological systems are organ-ized,maintain themselves and disin-tegrate(Prescher and Bertozzi,2005).For instance,green fl uorescent protein(GFP)derived from jellyfi sh Aequorea Victoria helps us to accurately locate and observe proteins over long term periods.In addition,many novel LOV(light,oxy-gen,or voltage)domains such as LOV2-Jαand Vivid offer the possibility of cell-based motility management and tissue-based gene expression control(Wu et al.,2009;Wang et al.,2012).
基金support from the National Basic Research Program(973 Program)(Nos.2013CB910103 and 2010CB912303)the National Natural Science Foundation of China(Grant Nos.31170818 and 31270910)the project from the Chinese Academy of Sciences(KSCX2-EW-Q-11).
文摘Lipid droplets, which are conserved across almost all species, are cytoplasmic organelles used to store neutral lipids. Identification of lipid droplet regulators will be conducive to resolving obesity and other fat-associated diseases. In this paper, we selected 11 candidates that might be associated with lipid metabolism in Caenorhabditis elegans . Using a BODIPY 493/503-based flow cytometry screen, 6 negative and 3 positive regulators of fat content were identified. We selected one negative regulator of lipid content, C13C4.5 , for future study. C13C4.5 was mainly expressed in the worm intestine. We found that this gene was important for maintaining the metabolism of lipid droplets. Biochemical results revealed that 50% of triacylglycerol (TAG) was lost in C13C4.5 knockout worms. Stimulated Raman scattering (SRS) signals in C13C4.5 mutants showed only 49.6% of the fat content in the proximal intestinal region and 86.3% in the distal intestinal region compared with wild type animals. The mean values of lipid droplet size and intensity in C13C4.5 knockout animals were found to be significantly decreased compared with those in wild type worms. The LMP-1-labeled membrane structures in worm intestines were also enlarged in C13C4.5 mutant animals. Finally, fertility defects were found in C13C4.5 ( ok2087 ) mutants. Taken together, these results indicate that C13C4.5 may regulate the fertility of C. elegans by changing the size and fat content of lipid droplets by interfering with lysosomal morphology and function.
基金the support from the members of Integrated Circuit Advanced Process R&D Center,Institute of Microelectronics,Chinese Academy of Sciencessupported in part by the National Key Project of Science and Technology of China(No.2017ZX02315001-002)。
文摘This article reviews advanced process and electron device technology of integrated circuits,including recent featuring progress and potential solutions for future development.In 5 years,for pushing the performance of fin field-effect transistors(FinFET)to its limitations,several processes and device boosters are provided.Then,the three-dimensional(3 D)integration schemes with alternative materials and device architectures will pave paths for future technology evolution.Finally,it could be concluded that Moore’s law will undoubtedly continue in the next 15 years.
基金Supported by National Natural Science Foundation of China(71671122)China Postdoctoral Science Foundation Funded Project(2014M560185,2016T90203)+1 种基金Humanities and Social Science Research Fund of Ministry of Education of China(11YJC790006,16YJA790004)Tianjin Natural Science Foundation of China(15JCQNJC04000)
文摘This paper studies a dynamic mean-variance portfolio selection problem with random liability in the affine interest rate environment, where the financial market consists of three assets: one risk-free asset, one risky asset and one zero-coupon bond. Assume that short rate is driven by affine interest rate model and liability process is described by the drifted Brownian motion, in addition, stock price dynamics is affected by interest rate dynamics. The investors expect to look for an optimal strategy to minimize the variance of the terminal surplus for a given expected terminal surplus. The efficient strategy and the efficient frontier are explicitly obtained by applying dynamic programming principle and Lagrange duality theorem. A numerical example is given to illustrate our results and some economic implications are analyzed.
基金the National Natural Science Foundation of China(nos.61875256,61925506,11674097,51525202,and U19A2090)the Natural Science Foundation of Shanghai(no.20JC1414605)the Key Program of the Hunan Provincial Science and Technology Department(no.2019XK2001)。
文摘Quantum dot microlasers,as multifunaional optical source components,are of great importance for full-color highpixel display,miniaturized coherent lighting,and on-chip integrated photonic and electronic circuits.Since the first synthesis of colloidal quantum dots(CQD)in the 1990s,motivation to realize high-performance low-cost CQD micro-/nanolasers has been a driving force for more than three decades.However,the low packing density,inefficient coupling of CQDs with optical cavities,and the poor thermal stability of miniaturized complex systems make it challenging to achieve practical CQD microVnanolasers,especially to combine the continuous working ability at high temperatures and the low-cost potential with mass-produced synthesis technologies.Herein,we developed closepacked CQD-assembled microspheres and embedded them in a silica matrix through the rapid self-aggregation and solidification of CdSe/ZnS CQD.This technology addresses the core issues of photoluminescence(PL)quenching effect and low optical gain in traditional CQD laser research.High-efficiency low-threshold CQD microlasers are demonstrated together with long-playing(40 min)working stability even at 450 K under pulsed laser excitation,which is the highest operational temperature for CQD lasers.Moreover,single-mode CQD microlasers are obtained with tunable wavelengths across the entire visible spectral range.The chemosynthesis process supports the mass-produced potential of high-density integrated CQD microlasers,promoting CQD-based low-cost high-temperature microdevices.