益气养心安神汤联合帕罗西汀对抑郁症失眠气郁痰阻证患者HAMD、CGI评分的影响

目的探讨益气养心安神汤联合帕罗西汀对抑郁症失眠气郁痰阻证患者汉密尔顿抑郁量表(HAMD)、临床总体印象量表(CGI)评分的影响。方法110例抑郁症失眠气郁痰阻证患者随机分为研究组和对照组,每组55例,分别给予益气养心安神汤联合帕罗西汀和单一帕罗西汀治疗,均治疗2个月。治疗结束比较其疗效及治疗前后中医证候积分,采用匹茨堡睡眠质量指数量表(PSQI)、失眠严重程度指数(ISI)评价其睡眠质量,同时应用HAMD、CGI量表分析其情绪、症状改善情况,并记录不良反应。结果研究组临床总有效率(92.73%)显著高于对照组(76.36%)(P<0.05);两组治疗后中医证候积分(情绪低落、急躁易怒、失眠多梦、胸闷气短、神疲)比同组治疗前均明显降低,且研究组低于对照组(P<0.05);研究组治疗后PSQI评分(7.93±1.89)分、ISI评分(9.42±1.51)分、HAMD评分(10.57±1.90)分、CGI评分(2.43±0.28)分均显著低于对照组(P<0.05);两组不良反应发生率比较差异无统计学意义(P>0.05)。结论益气养心安神汤联合帕罗西汀治疗抑郁症失眠气郁痰阻证,能有效改善患者抑郁症状,提高其睡眠质量,降低HAMD、CGI评分。

UHPLC-Q-Orbitrap-HRMS法分析补肾降浊颗粒的化学成分

采用超高效液相色谱-四级杆-静电场轨道阱高分辨质谱对复方中药制剂补肾降浊颗粒中的化学成分进行定性分析。样品采用WATERS ACQUITY UPLC BEH C18柱(1.7μm,2.1mm×50 mm)进行分离,以乙腈和0.1%甲酸水为流动相进行梯度洗脱,电喷雾质谱检测,正、负离子模式下采集数据,通过化合物的精确相对分子质量、质谱裂解规律以及文献报道的质谱数据进行对比分析,共鉴定出173个化合物,包括萜类45个,有机酸类36个,黄酮类26个,糖和苷类21个,酚类18个,苯丙素类10个,生物碱3个,其他类14个。所建立的方法首次对补肾降浊颗粒的化学成分进行快速表征,结果准确,可为进一步的药效物质基础和质量控制提供依据。

A cladding-pumping based power-scaled noise-like and dissipative soliton pulse fiber laser

We report a high-average-power noise-like pulse(NLP) and dissipative soliton(DS) pulse fiber laser. Average power as high as 4.8 W could be obtained at the fundamental mode-locked repetition rate. The NLP can also be transformed into a more powerful DS mode-locking state by optimizing the polarization and losses of intra-cavity pulses in the nonlinear polarization evolution regime. The operation mode between the NLP and DS can be switched, and the laser output performance in both modes has been studied. The main advantage of this work is switchable high-power operation between the NLP and DS. In comparison with conventional single-mode NLP fiber lasers, the multi-function high-power optical source will greatly push its application in supercontinuum generation, coherence tomography, and industrial processing.

High harmonic generation in crystal SiO_(2) by sub-10-fs laser pulses

The high harmonic generation(HHG)by few-cycle laser pulses is essential for research in strong-field solid-state physics.Through comparison of high harmonic spectra of solids generated by laser pulses with varying durations,we discovered that lasers with good dispersion compensation are capable of producing a broad spectrum of high harmonics.As the pulse duration is further compressed,several interference peaks appear in the broad spectrum.Moreover,we conducted simulations using the semiconductor Bloch equation,considering the effect of Berry curvature,to better understand this process.Our work provides a valuable approach for studying HHG by few-cycle laser pulses in solid materials,expanding the application of HHG in attosecond physics.

新型复合显影金属剥离工艺的研究

金属剥离工艺因其精确的线宽控制,低晶体损伤等优点,广泛应用于半导体光电器件电极制作工艺中。表面异物残留是影响金属剥离工艺质量的主要因素。本文分析了残留物形成的原因和机理,开发了复合显影金属剥离工艺,通过改进顶层光刻胶胶型,改善了顶层光刻胶侧壁金属膜致密性。显著降低了>5μm尺寸的缺陷数量,总缺陷数量较常规金属剥离工艺降低了87.5%,提高了金属剥离工艺质量。

DFB激光二极管光栅层的研究与制备

分布反馈(DFB)半导体激光器是现代光通信系统及红外探测中核心光源器件,外延结构一般由光栅材料层和量子阱材料层两大部分组成,其中光栅材料层中Bragg光栅制作质量的好坏对器件阈值和单模特性有直接影响。本文通过使用电子束光刻技术制作了高质量的Bragg光栅,较全息光刻技术所制光栅占空比均匀性由14.3%提高到了2.9%,改善了光栅材料层的质量,阈值电流标准差由0.47降至0.32,边模抑制比标准差由5.26降至0.72,提高了器件一致性,单片成品率提高了近10%。

Attosecond laser station

The attosecond laser station （ALS） at the Synergetic Extreme Condition User Facility （SECUF） is a sophisticated and user-friendly platform for the investigation of the electron dynamics in atoms, molecules, and condensed matter on timescales ranging from tens of femtoseconds to tens of attoseconds. Short and tunable coherent extreme-ultraviolet （XUV） light sources based on high-order harmonic generation in atomic gases are being developed to drive a variety of endstations for inspecting and controlling ultrafast electron dynamics in real time. The combination of such light sources and end-stations offers a route to investigate fundamental physical processes in atoms, molecules, and condensed matter. The ALS consists of four beamlines, each containing a light source designed specifically for application experiments that will be performed in its own end-station. The first beamline will produce broadband XUV light for attosecond photoelectron spectroscopy and attosecond transient absorption spectroscopy. It is also capable of performing attosecond streaking to characterize isolated attosecond pulses and will allow studies on the electron dynamics in atoms, moleculars, and condensed matter. The second XUV beamline will produce narrowband femtoseeond XUV pulses for time-resolved and angle-resolved photoelectron spectroscopy, to study the electronic dynamics on the timescale of fundamental correlations and interactions in solids, especially in superconductors and topological insulators. The third beamline will produce broadband XUV pulses for attosecond coincidence spectroscopy in a cold-target recoil-ion momentum spectrometer, to study the ultrafast dynamics and reactions in atomic and molecular systems. The last beamline produces broadband attosecond XUV pulses designed for time-resolved photoemission electron microscopy, to study the ultrafast dynamics of plasmons in nanostructures and the surfaces of solid materials with high temporal and spatial resolutions simultaneously. The main object of the ALS is to provide domestic and international scientists with unique tools to study fundamental processes in physics, chemistry, biology, and material sciences with ultrafast temporal resolutions on the atomic scale.

Growth and Characterization of High-quality LiAlO2 Single Crystal

γ-LiAlO2 single crystal is a promising substrate for GaN heteroepitaxy. In this paper, we present the growth of large-sized LiAlO2 crystal by modified Czochralski method. The crystal quality was characterized by high-resolution X-ray diffraction and chemical etching. The results show that the as-grown crystal has perfect quality with the full width at half maximum （FWHM） of 17.7-22.6 arcsec and etch pits density of （0.3- 2.2）×10^4 cm^-2 throughout the crystal boule. The bottom of the crystal boule shows the best quality. The optical transmission spectra from UV to IR exhibits that the crystal is transparent from 0.2 to 5.5μm and becomes completely absorbing around 6.7μm wavelength, The optical absorption edge in near UV region is about 191 nm.

Generation of Femtosecond Laser Pulse at 1.43 GHz from an Optical Parametric Oscillator Based on LBO Crystal

A femtosecond LBO optical parametric oscillator(OPO)with widely adjustable repetition rate by fractionally decrement of the cavity length is demonstrated.The repetition rate of 755 MHz to 1.43 GHz at an interval of 75.5 MHz is realized,which is 10 to 19 times that of the pump laser.The properties of output signal at 750 nm at different repetition rates are studied.The power of signal decreases with increasing the repetition rate.The maximum power of 194 mW at the repetition rate of 755 MHz and the minimum power of 22 mW at repetition rate of 1.43 GHz for the signal at 750 nm are obtained for the pump power of 3 W.

Broadband mid-infrared pulse via intra-pulse difference frequency generation based on supercontinuum from multiple thin plates

We report on the generation of optical pulses with a nearly one octave-spanning spectrum ranging from 1300 nm to2500 nm at 1 kHz repetition rate, which are based on intra-pulse difference frequency generation(DFG) in β-barium borate crystal(β-BBO) and passively carrier-envelope-phase(CEP) stabilized. The DFG is induced by few-cycle pulses initiated from spectral broadening in multiple thin plates driven by a Ti: sapphire chirped-pulse amplifier. Furthermore, a numerical simulation is developed to estimate the conversion efficiency and output spectrum of the DFG. Our results show that the pulses from the DFG have the potential for seeding intense mid-infrared(MIR) laser generation and amplification to study strong-field physics and attosecond science.

Femtosecond laser user facility for application research on ultrafast science

The advent of chirped-pulse amplification （CPA） has greatly advanced the field of ultrafast and ultra-intense laser technology. CPA has become an indispensable platform for multidisciplinary research, such as physics, chemistry, life sciences, and precision metrology. The femtosecond laser facility at the Synergic Extreme Condition User Facility （SECUF） is a comprehensive experimental platform with an advanced femtosecond laser source for ultrafast scientific research. It will provide an ultrafast scientific research system having a few-cycle pulse duration, wide spectral range, high energy, and high repetition rate for multipurpose applications.

All-fiber laser seeded femtosecond Yb:KGW solid state regenerative amplifier

A high efficiency compact Yb:KGW regenerative amplifier using an all-fiber laser seed source was comprehensively studied.With thermal lensing effect compensated by the cavity design,the compressed pulses with energy of 1 mJ at 1 kHz and 0.4 mJ at 10 kHz in sub-400-fs pulse duration using chirped fiber Bragg grating(CFBG)stretcher were demonstrated.A modified Frantz-Nodvik equation was developed to emulate the dynamic behavior of the regenerative amplifier.The simulation results were in good agreement with the experiment.Numerical simulations and experimental results show that the scheme can be scalable to higher energy of multi-mJ,sub-300 fs pulses.

Application and Experience of Putting People First in Hospital Human Resource Management

The recent years have witnessed the rapid economic growth of our country.The medical industry has also come to a new era.The number of hospital staff continues to increase,while some problems of managing human resource have gradually emerged.These problems have a bad impact on the functions of the hospital.We must attach great importance to solve them.In the process of managing the human resources of hospital,we must insist to put people first.That is how we can better boost the working initiative of medical staff,setting the foundation for the development of hospital in a long run.This article has conducted deepening research on this issue.First of all,it briefly introduced the theory of putting people first.And then it stated the connotation of the theory of putting people first applied in managing human resources of hospital.At last,it explored the strategies on applying the theory of putting people first in managing human resources of hospital in accordance to the concrete conditions.

Attosecond pulse trains driven by IR pulses spectrally broadened via supercontinuum generation in solid thin plates

We utilized a set of fused silica thin plates to broaden the spectrum of 1kHz,30 fs Ti:sapphire amplified laser pulses to an octave.Following the compression by chirped mirror pairs,the generated few-cycle pulses were focused onto an argon filled gas cell.We detected high order harmonics corresponding to a train of 209 as pulses,characterized by the reconstruction of attosecond beating by interference of two-photon transition(RABITT)technique.Compared with the conventional attosecond pulse trains,the broad harmonics in such pulse trains cover more energy range,so it is more efficient in studying some typical cases,such as resonances,with frequency resolved RABITT.As the solid thin plates can support high power supercontinuum generation,it is feasible to tailor the spectrum to have different central wavelength and spectral width,which will make the RABITT source work in different applications.

Properties of long light filaments in natural environment

The multiple filamentation of terawatt femtosecond （fs） laser pulses is experimentally studied in a natural environment. A more than 30-m long plasma filament with a millimeter diameter is formed by the collimated fs laser pulse freely propagating in an open atmosphere. This study provides the first quantitative experimental data about the electron density of a long range light filament in the atmosphere. The electron density of such a filament is quantitatively detected by using an electric method, showing that it is at the 1011-cm -3 level.

Enhancement of isolated attosecond pulse generation by using long gas medium

Isolated attosecond pulse generation in argon is theoretically investigated for different gas pressures and medium lengths.The output of attosecond pulse is effectively enhanced by using a longer gas medium with optimized pressure.The peak intensity of the attosecond pulse by using 6 mm gas medium is doubled compared with that of 1-3 mm gas cell,which is usually used in the experiment.Our simulation shows that the distortion of the driving laser waveform and the absorption are the main factors that limit the output of the attosecond pulse for the long gas medium.Optimized generation condition could be found by balancing the medium length and pressure.

血友病A患者26例基因突变类型及其与临床表型的关系

目的分析26例血友病A患者基因突变情况,探究基因突变与临床表型之间的关系。方法抽取2019年1月至2023年11月于郑州大学第三附属医院小儿血液科就诊并完善基因检测的血友病A患者26例进行回顾性分析,使用倒位位移聚合酶链式反应方法检测F8基因内含子22、内含子1的倒位,多重连接依赖式探针扩增法检测F8基因大片段缺失/重复,高通量测序技术检测F8基因点突变;采用一期法检测凝血因子Ⅷ活性水平(FⅧ:C),并根据患者FⅧ:C将其分为:轻型血友病A、中型血友病A、重型血友病A。结果26例血友病A患者中轻型6例,中型8例,重型12例。26例血友病A患者中内含子22倒位有4例(15.4%),内含子1倒位有1例(3.8%),错义突变有8例(30.7%),无义突变有1例(3.8%),移码突变6例(23.1%),大片段缺失有3例(11.8%),剪切位点突变有2例(7.6%),未检测到突变有1例(3.8%)。26例血友病A患者的基因检测结果中,共发现5种新发现的基因突变。25例检测出基因突变患者中有22例完善家系验证,其中19例患者的母亲为携带者,3例患者为自发突变。结论本研究中发生率最高的基因突变类型为错义突变,在重型血友病A中最常见的基因突变为移码突变和内含子倒位,在中型血友病A最常见的基因突变为错义突变,在轻型血友病A最常见的基因突变为错义突变。完善基因检测可明确诊断,避免误诊,更好地进行遗传咨询,同时可检测到新发现的突变以补充F8基因数据库。

交通基础设施质量对制造业价值链升级的影响研究

交通基础设施是影响一国制造业价值链位置的重要因素。运用《全球竞争力报告》和世界投入产出数据库(WIOD),分析交通基础设施质量对制造业价值链升级的影响,实证结果显示:交通基础设施质量的改善显著提升了制造业在全球价值链中的分工地位,并且促进其在价值链中的前向参与和后向参与程度。进一步研究发现,交通基础设施质量主要通过国际技术溢出与协同集聚对制造业价值链地位产生影响,而且对劳动密集型、资本密集型、技术密集型产业的提升作用依次递减,契约环境良好的地区交通基础设施质量对制造业价值链的提升作用更明显。因此,在构建双循环发展格局时,要充分意识到交通基础设施建设在制造业强国中的重要作用,加快交通运输的数字化、智能化和网络化建设,借助交通枢纽更好地融入全球产业链高端分工。

CALR基因Ⅰ型突变的儿童纤维化前期原发性骨髓纤维化1例

患儿男,8岁,以“头痛、呕吐”就诊,治疗过程中血小板计数最高2312×10^(9)/L,骨髓病理提示有核细胞增生过度,可见异形巨核细胞,部分呈“云朵样”,骨髓间质未见网状纤维明显增生,CALR基因Ⅰ型突变阳性,诊断为儿童纤维化前期原发性骨髓纤维化,给予重组人干扰素α、羟基脲及抗血小板药物治疗,半年后复查骨髓病理,未见纤维化进展及骨髓转化。随访2年半,无明显肝脾肿大、血栓及出血事件。

Characterizing 86-attosecond isolated pulses based on amplitude gating of high harmonic generation[Invited]

Isolated attosecond pulses(IAPs)are generated via applying amplitude gating on high-order harmonic generation driven by carrier-envelope phase stabilized 5.2 fs pulses with 0.5 mJ pulse energy at 770 nm central wavelength at the Synergetic Extreme Condition User Facility.A continuum ranging from 70 to 100 eV that supports sub-100-attosecond pulse is extracted by Zr foil and Mo/Si multilayer mirror.We demonstrate the characterization of the IAP.The retrieved pulse duration is 86attoseconds.The developed attosecond laser beamline with repetition rate up to 10 kHz is available for users to conduct attosecond photoelectron spectroscopy researches with a capability of coincidence measurement.