A perimeter security system based on ultra-weak fiber Bragg grating high-speed wavelength demodulation was proposed. The demodulation system for signal acquisition and high-speed wavelength calculation was designed ba...A perimeter security system based on ultra-weak fiber Bragg grating high-speed wavelength demodulation was proposed. The demodulation system for signal acquisition and high-speed wavelength calculation was designed based on field programmable gate array (FPGA) platform. The principle of ultra-weak fiber Bragg grating high-speed demodulation and signal recognition method were analyzed theoretically, and the Support Vector Machine model was introduced to optimize the event recognition accuracy of the system. A perimeter security experimental system containing 1000 ultra-weak fiber Bragg gratings, ultra-weak fiber Bragg grating sense optical cables with a diameter of 2.0 mm and a reflectivity of 0.01%, steel space frames and demodulation equipments was built to recognize four typical events such as knocking, shaking, wind blowing and rainfall. The experimental resulted show that the system has a spatial resolution of 1m and an acquisition frequency of 200 Hz. The joint time-frequency domain detection method is used to achieve 99.2% alarm accuracy, and 98% recognition accuracy of two intrusion events, which has good anti-interference performance.展开更多
BACKGROUND:The dynamic monitoring of immune status is crucial to the precise and individualized treatment of sepsis.In this study,we aim to introduce a model to describe and monitor the immune status of sepsis and to ...BACKGROUND:The dynamic monitoring of immune status is crucial to the precise and individualized treatment of sepsis.In this study,we aim to introduce a model to describe and monitor the immune status of sepsis and to explore its prognostic value.METHODS:A prospective observational study was carried out in Zhongshan Hospital,Fudan University,enrolling septic patients admitted between July 2016 and December 2018.Blood samples were collected at days 1 and 3.Serum cytokine levels(e.g.,tumor necrosis factor-α[TNF-α],interleukin-10[IL-10])and CD14+monocyte human leukocyte antigen-D-related(HLA-DR)expression were measured to serve as immune markers.Classifi cation of each immune status,namely systemic inflammatory response syndrome(SIRS),compensatory anti-inflammatory response syndrome(CARS),and mixed antagonistic response syndrome(MARS),was defined based on levels of immune markers.Changes of immune status were classifi ed into four groups which were stabilization(SB),deterioration(DT),remission(RM),and non-remission(NR).RESULTS:A total of 174 septic patients were enrolled including 50 non-survivors.Multivariate analysis discovered that IL-10 and HLA-DR expression levels at day 3 were independent prognostic factors.Patients with MARS had the highest mortality rate.Immune status of 46.1%patients changed from day 1 to day 3.Among four groups of immune status changes,DT had the highest mortality rate,followed by NR,RM,and SB with mortality rates of 64.7%,42.9%,and 11.2%,respectively.CONCLUSIONS:Severe immune disorder defi ned as MARS or deterioration of immune status defi ned as DT lead to the worst outcomes.The preliminary model of the classifi cation and dynamic monitoring of immune status based on immune markers has prognostic values and is worthy of further investigation.展开更多
文摘A perimeter security system based on ultra-weak fiber Bragg grating high-speed wavelength demodulation was proposed. The demodulation system for signal acquisition and high-speed wavelength calculation was designed based on field programmable gate array (FPGA) platform. The principle of ultra-weak fiber Bragg grating high-speed demodulation and signal recognition method were analyzed theoretically, and the Support Vector Machine model was introduced to optimize the event recognition accuracy of the system. A perimeter security experimental system containing 1000 ultra-weak fiber Bragg gratings, ultra-weak fiber Bragg grating sense optical cables with a diameter of 2.0 mm and a reflectivity of 0.01%, steel space frames and demodulation equipments was built to recognize four typical events such as knocking, shaking, wind blowing and rainfall. The experimental resulted show that the system has a spatial resolution of 1m and an acquisition frequency of 200 Hz. The joint time-frequency domain detection method is used to achieve 99.2% alarm accuracy, and 98% recognition accuracy of two intrusion events, which has good anti-interference performance.
基金the National Natural Science Foundation of China(81471840,81171837)the Shanghai Traditional Medicine Development Project(ZY3-CCCX3-3018,ZHYY-ZXYJH-201615)the Key Project of Shanghai Municipal Health Bureau(2016ZB0202).
文摘BACKGROUND:The dynamic monitoring of immune status is crucial to the precise and individualized treatment of sepsis.In this study,we aim to introduce a model to describe and monitor the immune status of sepsis and to explore its prognostic value.METHODS:A prospective observational study was carried out in Zhongshan Hospital,Fudan University,enrolling septic patients admitted between July 2016 and December 2018.Blood samples were collected at days 1 and 3.Serum cytokine levels(e.g.,tumor necrosis factor-α[TNF-α],interleukin-10[IL-10])and CD14+monocyte human leukocyte antigen-D-related(HLA-DR)expression were measured to serve as immune markers.Classifi cation of each immune status,namely systemic inflammatory response syndrome(SIRS),compensatory anti-inflammatory response syndrome(CARS),and mixed antagonistic response syndrome(MARS),was defined based on levels of immune markers.Changes of immune status were classifi ed into four groups which were stabilization(SB),deterioration(DT),remission(RM),and non-remission(NR).RESULTS:A total of 174 septic patients were enrolled including 50 non-survivors.Multivariate analysis discovered that IL-10 and HLA-DR expression levels at day 3 were independent prognostic factors.Patients with MARS had the highest mortality rate.Immune status of 46.1%patients changed from day 1 to day 3.Among four groups of immune status changes,DT had the highest mortality rate,followed by NR,RM,and SB with mortality rates of 64.7%,42.9%,and 11.2%,respectively.CONCLUSIONS:Severe immune disorder defi ned as MARS or deterioration of immune status defi ned as DT lead to the worst outcomes.The preliminary model of the classifi cation and dynamic monitoring of immune status based on immune markers has prognostic values and is worthy of further investigation.
