30~300 MHz的甚高频(Very High Frequency,VHF)频段是重要的射电天文波段,该频段观测采用天线阵组阵方式。稀布阵列具有空间分辨率高、副瓣电平低以及造价低等优点,进一步的天线阵综合加权可以对天线阵主瓣波束进行有效赋形,对最大旁瓣...30~300 MHz的甚高频(Very High Frequency,VHF)频段是重要的射电天文波段,该频段观测采用天线阵组阵方式。稀布阵列具有空间分辨率高、副瓣电平低以及造价低等优点,进一步的天线阵综合加权可以对天线阵主瓣波束进行有效赋形,对最大旁瓣副瓣(Maximum Side Lobe)电平和远区栅瓣(Far Side Lobe)电平进行抑制。首先回顾了射电天文甚高频稀布阵列研究发展和现状,以及将会遇到的难点,提出了首先优化最优稀布天线阵元排布,进一步提出融合高性能计算平台+FPGA SOPC的稀布甚高频射电天文阵列信号处理结构体系,在图形处理器(Graphics Processing Unit,GPU)或者云计算平台上完成对天线阵各阵元频点加权参数的计算,然后通过高速总线将计算参数下发到前端的信号处理板中,通过FPGA SOPC完成对加权参数的配发。进一步分析计算了多波束情况下的数据率,可以实现实时的参数配置。本文成果为下一步大规模甚高频天线阵架设提供了技术依据。展开更多
Background:Liver transplantation(LT)is the“cure”therapy for patients with hepatocellular carcinoma(HCC).However,some patients encounter HCC recurrence after LT.Unfortunately,there is no effective methods to identify...Background:Liver transplantation(LT)is the“cure”therapy for patients with hepatocellular carcinoma(HCC).However,some patients encounter HCC recurrence after LT.Unfortunately,there is no effective methods to identify the LT patients who have high risk of HCC recurrence and would benefit from adjuvant targeted therapy.The present study aimed to establish a scoring system to predict HCC recurrence of HCC patients after LT among the Chinese population,and to evaluate whether these patients are suitable for adjuvant targeted therapy.Methods:Clinical data of HCC patients who underwent LT from March 2015 to June 2019 were retrospectively collected and analyzed.Results:A total of 201 patients were included in the study.The multivariate Cox analysis suggested that preoperative alpha-fetoprotein(AFP)>200μg/L(HR=2.666,95%CI:1.515-4.690;P=0.001),glutamyl transferase(GGT)>96 U/L(HR=1.807,95%CI:1.012-3.224;P=0.045),and exceeding the Hangzhou criteria(HR=2.129,95%CI:1.158-3.914;P=0.015)were independent risk factors for poor disease-free survival(DFS)in patients with HCC who underwent LT.We established an AFP-GGT-Hangzhou(AGH)scoring system based on these factors,and divided cases into high-,moderate-,and low-risk groups.The differences in overall survival(OS)and disease-free survival(DFS)rates among the three groups were significant(P<0.05).The efficacy of the AGH scoring system to predict DFS was better than that of the Hangzhou criteria,UCSF criteria,Milan criteria,and TNM stage.Only in the high-risk group,we found that lenvatinib significantly improved prognosis compared with that of the control group(P<0.05).Conclusions:The AGH scoring system provides a convenient and effective way to predict HCC recurrence after LT in HCC patients in China.Patients with a high-risk AGH score may benefit from lenvatinib adjuvant therapy after LT.展开更多
文摘30~300 MHz的甚高频(Very High Frequency,VHF)频段是重要的射电天文波段,该频段观测采用天线阵组阵方式。稀布阵列具有空间分辨率高、副瓣电平低以及造价低等优点,进一步的天线阵综合加权可以对天线阵主瓣波束进行有效赋形,对最大旁瓣副瓣(Maximum Side Lobe)电平和远区栅瓣(Far Side Lobe)电平进行抑制。首先回顾了射电天文甚高频稀布阵列研究发展和现状,以及将会遇到的难点,提出了首先优化最优稀布天线阵元排布,进一步提出融合高性能计算平台+FPGA SOPC的稀布甚高频射电天文阵列信号处理结构体系,在图形处理器(Graphics Processing Unit,GPU)或者云计算平台上完成对天线阵各阵元频点加权参数的计算,然后通过高速总线将计算参数下发到前端的信号处理板中,通过FPGA SOPC完成对加权参数的配发。进一步分析计算了多波束情况下的数据率,可以实现实时的参数配置。本文成果为下一步大规模甚高频天线阵架设提供了技术依据。
基金supported by grants from the National Natural Science Foundation of China(81873874 and 82071797)Clinical Research Plan of SHDC(SHDC2020CR2021B and SHDC2020CR5012)+1 种基金Foundation of Science and Technology Commission of Shanghai Municipality(20Y11908500)Foundation of Shanghai Municipal Health Commission(201940032)。
文摘Background:Liver transplantation(LT)is the“cure”therapy for patients with hepatocellular carcinoma(HCC).However,some patients encounter HCC recurrence after LT.Unfortunately,there is no effective methods to identify the LT patients who have high risk of HCC recurrence and would benefit from adjuvant targeted therapy.The present study aimed to establish a scoring system to predict HCC recurrence of HCC patients after LT among the Chinese population,and to evaluate whether these patients are suitable for adjuvant targeted therapy.Methods:Clinical data of HCC patients who underwent LT from March 2015 to June 2019 were retrospectively collected and analyzed.Results:A total of 201 patients were included in the study.The multivariate Cox analysis suggested that preoperative alpha-fetoprotein(AFP)>200μg/L(HR=2.666,95%CI:1.515-4.690;P=0.001),glutamyl transferase(GGT)>96 U/L(HR=1.807,95%CI:1.012-3.224;P=0.045),and exceeding the Hangzhou criteria(HR=2.129,95%CI:1.158-3.914;P=0.015)were independent risk factors for poor disease-free survival(DFS)in patients with HCC who underwent LT.We established an AFP-GGT-Hangzhou(AGH)scoring system based on these factors,and divided cases into high-,moderate-,and low-risk groups.The differences in overall survival(OS)and disease-free survival(DFS)rates among the three groups were significant(P<0.05).The efficacy of the AGH scoring system to predict DFS was better than that of the Hangzhou criteria,UCSF criteria,Milan criteria,and TNM stage.Only in the high-risk group,we found that lenvatinib significantly improved prognosis compared with that of the control group(P<0.05).Conclusions:The AGH scoring system provides a convenient and effective way to predict HCC recurrence after LT in HCC patients in China.Patients with a high-risk AGH score may benefit from lenvatinib adjuvant therapy after LT.
