Association of serum pepsinogen with degree of gastric mucosal atrophy in an asymptomatic population

BACKGROUND Atrophic gastritis is a precancerous lesion of the stomach.It has been reported that pepsinogen(PG)can reflect the morphology and function of the gastric mucosa,and it is therefore used as a marker for the early diagnosis of atrophic gastritis.AIM To evaluate the diagnostic value of serum PG for degree of gastric mucosal atrophy in asymptomatic Chinese upon physical examination.METHODS Medical data were collected from subjects who underwent transnasal gastroscopy between October 2016 and October 2018.For each study subject,serum PG levels and presence of Helicobacter pylori(H.pylori)infection were investigated.Pathology was evaluated using the Operative Link for Gastritis Assessment(OLGA)classification and Operative Link on Gastric Intestinal Metaplasia Assessment(OLGIM)systems.All statistical analyses were carried out using SPSS statistical software.RESULTS A total of 2256 subjects were enrolled and 1922 cases were finally included in the study.Based on the OLGA grading system,the levels of PGI were slightly decreased,while those of PGII were slightly increased.The PGI/PGII ratio(PGR)was reduced with increasing atrophy.The association between PG and OLGA grading was higher compared with that between PG and the OLGIM grading system.Compared with the OLGA-0 group,a statistically significant difference was observed in the mean age of OLGA-Ⅰ,Ⅲ,and Ⅳ groups(P<0.05).In the H.pylori-positive subjects,the PGR levels were notably lower in the OLGA-Ⅰ,Ⅱ,and Ⅲ groups compared with the OLGA-0 group(P<0.05).H.pylori-positive subjects exhibited significantly higher PGI and PGII serum levels and a significantly lower PGR compared with H.pylori-negative patients in different OLGA groups(P<0.05).CONCLUSION Serum PG levels may represent a non-invasive screening marker for gastric mucosal atrophy in asymptomatic subjects.

近端胰腺非侵袭性肿瘤剜除手术:指征及与传统标准切除手术效果比较（英文）

目的:评价近端胰腺非侵袭性肿瘤剜除手术的安全性与有效性。创新点:以目前为止最大样本量的近端胰腺非侵袭性肿瘤的剜除手术的数据分析,证实了剜除手术在这类患者中的安全性和有效性,即使肿瘤直径>3 cm或临近主胰管肿瘤。并且首次报道和证实了在这些患者剜除手术中发生主胰管损伤,进行主胰管修补与支架置入是安全有效的。分析了同期进行不同手术方式患者的肿瘤资料,阐明了肿瘤大小影响手术策略的制定。方法:详细对比了剜除手术和传统的胰十二脂肠切除术以及胰腺中段切除术的术前情况、术中情况、术后并发症资料(表1~3),尤其详细描述了临近主胰管和主胰管有损伤的患者剜除手术后并发症情况(表4)。同时,附图说明了主胰管修补手术方法(图1)。结论:近端胰腺非侵袭性肿瘤的剜除手术是安全有效的,应该是这类患者手术治疗的首选推荐方式,在大肿瘤和临近主胰管的肿瘤患者中也可施行。