For cell culture scaffold innovation,3DPVS,namely 3D printed vibratory scaffold,was indicated as a future novel product,and it currently stands at conceptual development stage.One essential part for 3DPVS design is in...For cell culture scaffold innovation,3DPVS,namely 3D printed vibratory scaffold,was indicated as a future novel product,and it currently stands at conceptual development stage.One essential part for 3DPVS design is innovation,and TRIZ(algorithm of inventive problem solving)was studied as promising method for generating novel conceptual solutions.This study targets designing and solving 3DPVS problems using TRIZ in the new biodimension.We aim to utilize TRIZ to conduct a multi-layer problem-solving process,which is to address design concerns of 3DPVS,especially at super-system to system level.In this connection,TRIZ is used to address basic constraints and contradictions inside regarding trinity of 3D printing,3D scaffold and bio-based vibratory functionality.In the study,five basic conceptual solutions for potential 3DPVS,namely magnetic,electric,mechanical,light and thermal based,have been generated.A brief evaluation has also been conducted,where magnetic-based 3DPVS shows the relatively highest applicability as potential 3DPVS.Compared with traditional experimental-oriented processes for biodesign,the approach of utilizing TRIZ can be inspiring and reinvigorating,which prepares a ground for future 3DPVS design to address detailed sub-system concerns.This study might,to some extent,fill a gap in scaffold design and TRIZ literature and hopefully provide a comprehensive perspective of a timely topic.展开更多
Granular hydroxyl-functionalized UHMWPE was successfully prepared through copolymerization of ethylene and 10-undecen-1-ol protected by tri-iso-butylaluminum using a titanium complex.[tBuNSiMe_(2)(2,7-tBu2Flu)]TiMe_(2...Granular hydroxyl-functionalized UHMWPE was successfully prepared through copolymerization of ethylene and 10-undecen-1-ol protected by tri-iso-butylaluminum using a titanium complex.[tBuNSiMe_(2)(2,7-tBu2Flu)]TiMe_(2) was activated in hexane by silica-supported modified-methylaluminoxane.Without any additional pretreatments,the obtained polymer powders were transformed into fibers through a gel-spinning and heat drawing process.When compared to fibers generated from the equivalent unfunctionalized UHMWPE or the commercial HUMWPE,both creep resistance and hydrophilic properties were improved in the hydroxy-functionalized UHMWPE fibers without losing tensile strength.展开更多
文摘For cell culture scaffold innovation,3DPVS,namely 3D printed vibratory scaffold,was indicated as a future novel product,and it currently stands at conceptual development stage.One essential part for 3DPVS design is innovation,and TRIZ(algorithm of inventive problem solving)was studied as promising method for generating novel conceptual solutions.This study targets designing and solving 3DPVS problems using TRIZ in the new biodimension.We aim to utilize TRIZ to conduct a multi-layer problem-solving process,which is to address design concerns of 3DPVS,especially at super-system to system level.In this connection,TRIZ is used to address basic constraints and contradictions inside regarding trinity of 3D printing,3D scaffold and bio-based vibratory functionality.In the study,five basic conceptual solutions for potential 3DPVS,namely magnetic,electric,mechanical,light and thermal based,have been generated.A brief evaluation has also been conducted,where magnetic-based 3DPVS shows the relatively highest applicability as potential 3DPVS.Compared with traditional experimental-oriented processes for biodesign,the approach of utilizing TRIZ can be inspiring and reinvigorating,which prepares a ground for future 3DPVS design to address detailed sub-system concerns.This study might,to some extent,fill a gap in scaffold design and TRIZ literature and hopefully provide a comprehensive perspective of a timely topic.
基金This work was supported by the Fundamental Research Funds for the Central Universities(2232020A-05)National Natural Science Foundation of China(21174026)the Program for Professor of Special Appointment(Eastern Scholar)at Shanghai Institutions of Higher Learning.
文摘Granular hydroxyl-functionalized UHMWPE was successfully prepared through copolymerization of ethylene and 10-undecen-1-ol protected by tri-iso-butylaluminum using a titanium complex.[tBuNSiMe_(2)(2,7-tBu2Flu)]TiMe_(2) was activated in hexane by silica-supported modified-methylaluminoxane.Without any additional pretreatments,the obtained polymer powders were transformed into fibers through a gel-spinning and heat drawing process.When compared to fibers generated from the equivalent unfunctionalized UHMWPE or the commercial HUMWPE,both creep resistance and hydrophilic properties were improved in the hydroxy-functionalized UHMWPE fibers without losing tensile strength.
