Objective The objective of the study was to identify the risk factors correlated with spontaneous preterm birth(SPTB)and iatrogenic preterm birth(IPTB),as well as to compare the pregnancy outcomes between SPTB and IPT...Objective The objective of the study was to identify the risk factors correlated with spontaneous preterm birth(SPTB)and iatrogenic preterm birth(IPTB),as well as to compare the pregnancy outcomes between SPTB and IPTB.Materials and methods A total of 1676(343 SPTB,144 IPTB and 1189 full-term control group)cases were collected from the International Peace Maternity&Child Health Hospital of Shanghai between August 2018 and October 2020.A case-control study was conducted to explore the risk factors and pregnancy outcomes of SPTB and IPTB.Results The study identified a set of risk factors for SPTB and IPTB,as well as differences in pregnancy outcomes.Reproductive tract infections and myoma of the uterus were the risk factors for SPTB(p<0.05).Fetal growth restriction,pre-eclampsia,intrahepatic cholestasis of pregnancy,fetal distress,placenta abnormality,oligohydramnios and scarred uterus were the risk factors for IPTB(p<0.05).Antenatal haemorrhage and placental abruption were the risk factors both for SPTBand IPTB(p<0.05).The pregnancy outcomes of the two PTB gubtypes differed,and birth woight,longth and 1-minute Apgar score of newborns were significantly lower in IPTB than in SPTB(p<0.05).Conclusion The risk factors of SPTBand IPTB are different,and IPTB is associated with a higher incidence of worse pregnancy outcomes than SPTB.展开更多
Gene editing is the specific modification of genome sequences at desired sites using technologies derived from zinc finger nucleases(ZFNs),transcription activator-like effector nucleases(TALENs)and clustered regularly...Gene editing is the specific modification of genome sequences at desired sites using technologies derived from zinc finger nucleases(ZFNs),transcription activator-like effector nucleases(TALENs)and clustered regularly interspaced short palindromic repeats(CRISPR)-CRISPR-associated(Cas)nuclease systems.It is a promising tool for the development of new treatment strategies for infectious diseases.Due to its higher editing efficiency and lower off-target effect,gene editing therapy mainly uses CRISPR Cas-derived tools to resist viral and non-viral infections.Here,we reviewed the recent research progress of gene editing in antiviral therapy(human immunodeficiency virus,hepatitis B virus,severe acute respiratory syndrome coronavirus 2,and human papillomavirus)and inhibition of infectious diseases that involve bacteria,fungi and parasites.展开更多
文摘Objective The objective of the study was to identify the risk factors correlated with spontaneous preterm birth(SPTB)and iatrogenic preterm birth(IPTB),as well as to compare the pregnancy outcomes between SPTB and IPTB.Materials and methods A total of 1676(343 SPTB,144 IPTB and 1189 full-term control group)cases were collected from the International Peace Maternity&Child Health Hospital of Shanghai between August 2018 and October 2020.A case-control study was conducted to explore the risk factors and pregnancy outcomes of SPTB and IPTB.Results The study identified a set of risk factors for SPTB and IPTB,as well as differences in pregnancy outcomes.Reproductive tract infections and myoma of the uterus were the risk factors for SPTB(p<0.05).Fetal growth restriction,pre-eclampsia,intrahepatic cholestasis of pregnancy,fetal distress,placenta abnormality,oligohydramnios and scarred uterus were the risk factors for IPTB(p<0.05).Antenatal haemorrhage and placental abruption were the risk factors both for SPTBand IPTB(p<0.05).The pregnancy outcomes of the two PTB gubtypes differed,and birth woight,longth and 1-minute Apgar score of newborns were significantly lower in IPTB than in SPTB(p<0.05).Conclusion The risk factors of SPTBand IPTB are different,and IPTB is associated with a higher incidence of worse pregnancy outcomes than SPTB.
基金supported by the National Key R&D Program of China(2019YFA0109900,2019YFA0109901,2019YFA0802800,2019YFA0110803)the Shanghai Municipal Commission for Science and Technology(19PJ1403500)the National Natural Science Foundation of China(82270125)
文摘Gene editing is the specific modification of genome sequences at desired sites using technologies derived from zinc finger nucleases(ZFNs),transcription activator-like effector nucleases(TALENs)and clustered regularly interspaced short palindromic repeats(CRISPR)-CRISPR-associated(Cas)nuclease systems.It is a promising tool for the development of new treatment strategies for infectious diseases.Due to its higher editing efficiency and lower off-target effect,gene editing therapy mainly uses CRISPR Cas-derived tools to resist viral and non-viral infections.Here,we reviewed the recent research progress of gene editing in antiviral therapy(human immunodeficiency virus,hepatitis B virus,severe acute respiratory syndrome coronavirus 2,and human papillomavirus)and inhibition of infectious diseases that involve bacteria,fungi and parasites.
