Based on the recent development of renewable energy utilization technology,in addition to centralized photovol-taic power plants,distributed photovoltaic power generation systems represented by building-integrated pho...Based on the recent development of renewable energy utilization technology,in addition to centralized photovol-taic power plants,distributed photovoltaic power generation systems represented by building-integrated photo-voltaic systems are frequently employed for power supply.Therefore,in the architectural design,the double-glass photovoltaic module used in the integrated photovoltaic building system puts forward a higher load-bearing capa-city requirement and the corresponding simplified method of carrying capacity check.This article focuses on the simplified method of checking the bearing capacity of the four-sided simply supported double-glass photovoltaic module.First,the principle of equivalent stiffness is used to calculate the effective thickness.Then,the rationality of this approach is verified by comparing the bending states of sandwich panels under different shear moduli.The double-glass photovoltaic module is equivalent to a single-layer board,and its effectiveness is verified by compar-ing the impact test results of the double-glass photovoltaic module with the results of the single-layer board.But the comparison with the test results shows that,from the perspective of architectural design,the effective thick-ness results in this paper can ensure that the building structure has sufficient bearing capacity,but the four-side simply supported boundary theory cannot fully reflect the calculation of the bearing capacity of the four-side clamped double-glass photovoltaic module.展开更多
The coronavirus disease 2019(COVID-19)pandemic,caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),has claimedmillions of lives and caused innumerable economic losses worldwide.Unfortunately,state-of...The coronavirus disease 2019(COVID-19)pandemic,caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),has claimedmillions of lives and caused innumerable economic losses worldwide.Unfortunately,state-of-the-art treatments still lag behind the continual emergence of new variants.Key to resolving this issue is developing antivirals to deactivate coronaviruses regardless of their structural evolution.Here,we report an innovative antiviral strategy involving extracellular disintegration of viral proteins with hyperanion-grafted enediyne(EDY)molecules.The core EDY generates reactive radical species and causes significant damage to the spike protein of coronavirus,while the hyperanion groups ensure negligible cytotoxicity of the molecules.The EDYs exhibit antiviral activity down to nanomolar concentrations,and the selectivity index of up to 20,000 against four kinds of human coronavirus,including the SARS-CoV-2 Omicron variant,suggesting the high potential of this new strategy in combating the COVID-19 pandemic and a future“disease X.”展开更多
基金This research was funded by the National Key Research and Development Program of China:Newton Fund-China-UK Research and Innovations Bridges(No.2016YFE0124500).
文摘Based on the recent development of renewable energy utilization technology,in addition to centralized photovol-taic power plants,distributed photovoltaic power generation systems represented by building-integrated photo-voltaic systems are frequently employed for power supply.Therefore,in the architectural design,the double-glass photovoltaic module used in the integrated photovoltaic building system puts forward a higher load-bearing capa-city requirement and the corresponding simplified method of carrying capacity check.This article focuses on the simplified method of checking the bearing capacity of the four-sided simply supported double-glass photovoltaic module.First,the principle of equivalent stiffness is used to calculate the effective thickness.Then,the rationality of this approach is verified by comparing the bending states of sandwich panels under different shear moduli.The double-glass photovoltaic module is equivalent to a single-layer board,and its effectiveness is verified by compar-ing the impact test results of the double-glass photovoltaic module with the results of the single-layer board.But the comparison with the test results shows that,from the perspective of architectural design,the effective thick-ness results in this paper can ensure that the building structure has sufficient bearing capacity,but the four-side simply supported boundary theory cannot fully reflect the calculation of the bearing capacity of the four-side clamped double-glass photovoltaic module.
基金the National Natural Science Foundation of China(grant no.21871080)the Eastern Scholar Professorship(for A.H.)the Natural Science Foundation of Shanghai(grant no.20ZR1463900)(for J.L.).
文摘The coronavirus disease 2019(COVID-19)pandemic,caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),has claimedmillions of lives and caused innumerable economic losses worldwide.Unfortunately,state-of-the-art treatments still lag behind the continual emergence of new variants.Key to resolving this issue is developing antivirals to deactivate coronaviruses regardless of their structural evolution.Here,we report an innovative antiviral strategy involving extracellular disintegration of viral proteins with hyperanion-grafted enediyne(EDY)molecules.The core EDY generates reactive radical species and causes significant damage to the spike protein of coronavirus,while the hyperanion groups ensure negligible cytotoxicity of the molecules.The EDYs exhibit antiviral activity down to nanomolar concentrations,and the selectivity index of up to 20,000 against four kinds of human coronavirus,including the SARS-CoV-2 Omicron variant,suggesting the high potential of this new strategy in combating the COVID-19 pandemic and a future“disease X.”