In a recent study in Nature,Kadosh et al.1 established a landmark relationship between the gut microbiome and host epigenetics in intestinal oncogenesis.They demonstrated the substantial plasticity of mutant p53 in WN...In a recent study in Nature,Kadosh et al.1 established a landmark relationship between the gut microbiome and host epigenetics in intestinal oncogenesis.They demonstrated the substantial plasticity of mutant p53 in WNT-driven tumorigenesis,and the crucial involvement of gut microbiome in modulating this plasticity.展开更多
Human gastrointestinal tract harbors trillions of commensal microbes including bacteria,viruses,and fungi to form an ecological community,commonly known as the gut microbiome.Being the second most dominant taxonomic k...Human gastrointestinal tract harbors trillions of commensal microbes including bacteria,viruses,and fungi to form an ecological community,commonly known as the gut microbiome.Being the second most dominant taxonomic kingdom in the gut(5.8%of total microbiome DNA),enteric viruses are increasingly acknowledged for their roles in shaping the overall composition of the gut microbiome and maintaining human health.[1,2]Recent advancements in metagenomic sequencing have brought breakthrough in deciphering the features and functions of the gut virome.展开更多
In a recent study in Nature,Wu et al.discovered a fundamental host–microbe interaction that is crucially involved in responding to dietary change thereby maintaining healthy intestinal dynamics.1 They demonstrated th...In a recent study in Nature,Wu et al.discovered a fundamental host–microbe interaction that is crucially involved in responding to dietary change thereby maintaining healthy intestinal dynamics.1 They demonstrated that HDAC3 activity can be promoted by microbiota-mediated phytate metabolism to contribute intestinal homeostasis and repair.展开更多
基金supported by National Key R&D Program of China(No.2018YFC1315000/2018YFC1315004)RGC-CRF Hong Kong(C4039-19G)and RGCGRF Hong Kong(14163817).
文摘In a recent study in Nature,Kadosh et al.1 established a landmark relationship between the gut microbiome and host epigenetics in intestinal oncogenesis.They demonstrated the substantial plasticity of mutant p53 in WNT-driven tumorigenesis,and the crucial involvement of gut microbiome in modulating this plasticity.
文摘Human gastrointestinal tract harbors trillions of commensal microbes including bacteria,viruses,and fungi to form an ecological community,commonly known as the gut microbiome.Being the second most dominant taxonomic kingdom in the gut(5.8%of total microbiome DNA),enteric viruses are increasingly acknowledged for their roles in shaping the overall composition of the gut microbiome and maintaining human health.[1,2]Recent advancements in metagenomic sequencing have brought breakthrough in deciphering the features and functions of the gut virome.
基金supported was supported by National Key R&D Program of China(No.2018YFC1315000/2018YFC1315004)RGC-CRF Hong Kong(C4039-19G)RGC-GRF Hong Kong(14163817).
文摘In a recent study in Nature,Wu et al.discovered a fundamental host–microbe interaction that is crucially involved in responding to dietary change thereby maintaining healthy intestinal dynamics.1 They demonstrated that HDAC3 activity can be promoted by microbiota-mediated phytate metabolism to contribute intestinal homeostasis and repair.
