Aminoalkyl methacrylate copolymer,Eudragit?E PO(EPO),has been used as a polymeric carrier for solid dispersion to significantly enhance the drug dissolution.However,the improvement of the drug dissolution by the drug/...Aminoalkyl methacrylate copolymer,Eudragit?E PO(EPO),has been used as a polymeric carrier for solid dispersion to significantly enhance the drug dissolution.However,the improvement of the drug dissolution by the drug/EPO solid dispersion is limited only in acidic solution due to the pHdependant solubility of basic EPO with its tertiary amino group.We previously reported that the blending of saccharin(SAC)in the drug/EPO solid dispersion led to the supersaturation formation of drug even at neutral pH[1].展开更多
文摘Aminoalkyl methacrylate copolymer,Eudragit?E PO(EPO),has been used as a polymeric carrier for solid dispersion to significantly enhance the drug dissolution.However,the improvement of the drug dissolution by the drug/EPO solid dispersion is limited only in acidic solution due to the pHdependant solubility of basic EPO with its tertiary amino group.We previously reported that the blending of saccharin(SAC)in the drug/EPO solid dispersion led to the supersaturation formation of drug even at neutral pH[1].
