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Generation and Regulation of CD8^+ Regulatory T Cells 被引量:23
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作者 Linrong Lu harvey cantor 《Cellular & Molecular Immunology》 SCIE CAS CSCD 2008年第6期401-406,共6页
Research into the suppressive activity of CD4+FoxP3+ T regulatory cells (Treg) has defined a sublineage of CD4+ cells that contribute to self-tolerance and resistance to autoimmune disease. Much less attention ha... Research into the suppressive activity of CD4+FoxP3+ T regulatory cells (Treg) has defined a sublineage of CD4+ cells that contribute to self-tolerance and resistance to autoimmune disease. Much less attention has been given to the potential contribution of regulatory sublineages of CD8+ cells. Analysis of a small fraction of CD8+ cells that target autoreactive CD4+ cells through recognition of the MHC class Ib molecule Qa-1 in mouse and HLA-E in human has revitalized interest in CD8+ Treg. Here we summarize recent progress and future directions of research into the role of this CD8+ sublineage in resistance to autoimmune disease. Cellular & Molecular Immunology. 2008; 5(6):401-406. 展开更多
关键词 CD8+ regulatory T cell SELF-TOLERANCE autoimmune disease EAE Qa-1 NKG2A
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