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High-resolution impedance mapping using electrically activated quantitative phase imaging 被引量:3
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作者 Cristina Polonschii Mihaela Gheorghiu +6 位作者 Sorin David Szilveszter Gáspár Sorin Melinte hassaan majeed Mikhail E.Kandel Gabriel Popescu Eugen Gheorghiu 《Light(Science & Applications)》 SCIE EI CAS CSCD 2021年第2期186-196,共11页
Retrieving electrical impedance maps at the nanoscale rapidly via nondestructive inspection with a high signal-to-noise ratio is an unmet need,likely to impact various applications from biomedicine to energy conversio... Retrieving electrical impedance maps at the nanoscale rapidly via nondestructive inspection with a high signal-to-noise ratio is an unmet need,likely to impact various applications from biomedicine to energy conversion.In this study,we develop a multimodal functional imaging instrument that is characterized by the dual capability of impedance mapping and phase quantitation,high spatial resolution,and low temporal noise.To achieve this,we advance a quantitative phase imaging system,referred to as epi-magnified image spatial spectrum microscopy combined with electrical actuation,to provide complementary maps of the optical path and electrical impedance.We demonstrate our system with high-resolution maps of optical path differences and electrical impedance variations that can distinguish nanosized,semi-transparent,structured coatings involving two materials with relatively similar electrical properties.We map heterogeneous interfaces corresponding to an indium tin oxide layer exposed by holes with diameters as small as~550 nm in a titanium(dioxide)over-layer deposited on a glass support.We show that electrical modulation during the phase imaging of a macro-electrode is decisive for retrieving electrical impedance distributions with submicron spatial resolution-and beyond the limitations of electrode-based technologies(surface or scanning technologies).The findings,which are substantiated by a theoretical model that fits the experimental data very well enable achieving electro-optical maps with high spatial and temporal resolutions.The virtues and limitations of the novel optoelectrochemical method that provides grounds for a wider range of electrically modulated optical methods for measuring the electric field locally are critically discussed. 展开更多
关键词 IMPEDANCE RESOLUTION phase
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Bond-selective transient phase imaging via sensing of the infrared photothermal effect 被引量:3
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作者 Delong Zhang Lu Lan +4 位作者 Yeran Bai hassaan majeed Mikhail E.Kandel Gabriel Popescu Ji-Xin Cheng 《Light(Science & Applications)》 SCIE EI CAS CSCD 2019年第1期70-81,共12页
Phase-contrast microscopy converts the phase shift of light passing through a transparent specimen,e.g.,a biological cell,into brightness variations in an image.This ability to observe structures without destructive f... Phase-contrast microscopy converts the phase shift of light passing through a transparent specimen,e.g.,a biological cell,into brightness variations in an image.This ability to observe structures without destructive fixation or staining has been widely utilized for applications in materials and life sciences.Despite these advantages,phase-contrast microscopy lacks the ability to reveal molecular information.To address this gap,we developed a bond-selective transient phase(BSTP)imaging technique that excites molecular vibrations by infrared light,resulting in a transient change in phase shift that can be detected by a diffraction phase microscope.By developing a time-gated pump-probe camera system,we demonstrate BSTP imaging of live cells at a 50 Hz frame rate with high spectral fidelity,sub-microsecond temporal resolution,and sub-micron spatial resolution.Our approach paves a new way for spectroscopic imaging investigation in biology and materials science. 展开更多
关键词 TRANSIENT phase utilized
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